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IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping IKZF3 Antibodies (136) and IKZF3 Proteins (5) and many more products for this protein.
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These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.
study demonstrated that Aiolos silenced the Il2 (show IL2 ELISA Kits) locus, promoting TH17 differentiation in vitro and in vivo
Aiolos and Ikaros (show IKZF1 ELISA Kits) bind to the c-myc (show MYC ELISA Kits) promoter in vivo and directly suppress c-myc (show MYC ELISA Kits) expression in pre-B cells.
Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.
A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (show IL4 ELISA Kits)-deprived cells via association to the transcription factor Aiolos.
Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.
A novel role for OBF-1 (show POU2AF1 ELISA Kits) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (show BCR ELISA Kits) function.
this study shows that Ikaros (show IKZF1 ELISA Kits) undergoes a transient increase in protein levels at the transitional single-positive CD8 (show CD8A ELISA Kits)+ developmental stage before diverging in their expression patterns at later stages
Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 (show IQGAP1 ELISA Kits) variants.
results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA
Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.
NFKB1 (show NFKB1 ELISA Kits), CD27 (show CD27 ELISA Kits), LAG3 (show LAG3 ELISA Kits) and IKZF3 are new susceptibility genes for psoriasis.
lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (show NFKB1 ELISA Kits) activity.
The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (show ZPBP2 ELISA Kits) locus confers risk for early-onset psoriasis.
A strong association between rs907091 in the IKZF3 gene and SLE was identified.
The immunosuppressive enzyme IL4I1 (show IL4I1 ELISA Kits) expressed differentially in human induced Aiolos+, but not natural Helios (show ZNFN1A2 ELISA Kits)+, FOXP3 (show FOXP3 ELISA Kits)+ Treg cells.
A strong allelic association between SNPs in the 17q21 region (IKZF3) and asthma has been confirmed for the Latinos population.
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
ikaros family zinc finger protein 3
, zinc finger protein Aiolos
, zinc finger protein, subfamily 1A, 3 (Aiolos)
, lymphoid transcription factor