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The protein encoded by INO80 represents the catalytic ATPase subunit of the INO80 chromatin remodeling complex. Additionally we are shipping and many more products for this protein.
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INO80 complex negatively regulates p21 (show CDKN1A Antibodies) expression in a p53 (show TP53 Antibodies)-mediated mechanism and is implicated in cell cycle phase G2/M arrest and abnormal chromosome stability.
INO80 is stabilized and targeted to replication forks by BAP1 (show RNF2 Antibodies) during normal DNA synthesis but downregulated in BAP1 (show RNF2 Antibodies) defective cancer cells
Mutations in INO80D is associated with translocation renal cell carcinoma (show MOK Antibodies).
The data indicate that under conditions of replication stress INO80 protects stalled forks from collapsing and allows their subsequent restart.
human Inositol auxotrophy 80 (Ino80) SNF2 (show SMARCA2 Antibodies) ATPase is (show ATP11A Antibodies) subject to regulation at multiple levels in the INO80 chromatin-remodeling complex.
These results suggest that the human INO80 complex, like the yeast complex, was involved in the DNA damage tolerance pathway and that phosphorylation of human INO80 was involved in the DNA damage tolerance pathway.
These results suggest that hIno80 can play a direct role in the spindle assembly independent of its chromatin remodeling activity.
Ino80 mediates double-strand break repair through its role in DNA end strand resection
Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.
These results suggest that hINO80 assists double-strand break repair by positively regulating the expression of the Rad54B (show RAD54B Antibodies) and XRCC3 (show XRCC3 Antibodies) genes.
The loss of INO80 resulted in an arrest during meiosis associated with a failure to repair DNA damage during meiotic recombination
Ino80 represses Bmp4 (show BMP4 Antibodies) expression during embryonic stem cell differentiation.
INO80 is stabilized and targeted to replication forks by BAP1 (show BAP1 Antibodies) during normal DNA synthesis but downregulated in BAP1 (show BAP1 Antibodies) defective cancer cells
data reveal an essential role for INO80 in the expression of the pluripotency network and illustrate the coordination among chromatin remodeler, transcription factor, and histone-modifying enzyme in the regulation of the pluripotent state.
The mIno80 chromatin remodeling complex plays important roles in telomere replication, HDR (show GATA3 Antibodies)-mediated repair of dysfunctional telomeres, and maintenance of genome stability.
observations reveal a link between YY1 (show YY1 Antibodies) and INO80 and roles for both in homologous recombination-based repair, providing new insight into mechanisms that control the cellular response to genotoxic stress
The protein encoded by this gene represents the catalytic ATPase subunit of the INO80 chromatin remodeling complex. This complex binds DNA and is recruited by YY1 to activate certain genes.
DNA helicase INO80
, INO80 complex subunit A
, INO80 homolog
, homolog of yeast INO80
, putative DNA helicase INO80 complex homolog 1
, INO80 complex homolog 1
, yeast INO80-like protein