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IQ Motif Containing B1 (IQCB1) ELISA Kits

IQCB1 encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. Additionally we are shipping IQ Motif Containing B1 Antibodies (38) and IQ Motif Containing B1 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat IQCB1 IQCB1 303915  
Anti-Mouse IQCB1 IQCB1 320299 Q8BP00
Anti-Human IQCB1 IQCB1 9657 Q15051
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More ELISA Kits for IQ Motif Containing B1 Interaction Partners

Mouse (Murine) IQ Motif Containing B1 (IQCB1) interaction partners

  1. Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290 (show CEP290 ELISA Kits)) blindness: generation of an all-cone Nphp6 (show CEP290 ELISA Kits) hypomorph mouse that mimics the human retinal ciliopathy.

Human IQ Motif Containing B1 (IQCB1) interaction partners

  1. NPHP5 and Cep290 (show CEP290 ELISA Kits) regulate BBSome integrity, ciliary trafficking and cargo delivery.

  2. High-throughput mutation analysis identified a homozygous truncating mutation (c.1504C>T, p.R502*) in the NPHP5 in 5 families in Iranian children with nephronophthisis.

  3. mutation is predicted to introduce a new open reading frame that results in the truncation of the C-terminal 235 amino acids of nephrocystin-5 and its consequent loss of function

  4. NPHP5 mutations impair protein interaction with Cep290 (show CEP290 ELISA Kits) and localize to centrosomes, thereby compromising cilia formation.

  5. in a set of consanguineous patient families with Leber congenital amaurosis study identified five putative disease-causing mutations, including four novel alleles, in six families; These five mutations are located in four genes, ALMS1 (show ALMS1 ELISA Kits), IQCB1, CNGA3 (show CNGA3 ELISA Kits), and MYO7A (show MYO7A ELISA Kits)

  6. Data show that the minor allele (N) of I393N in IQCB1 and the common allele (R) of R744Q in RPGRIP1L (show RPGRIP1L ELISA Kits) were associated with severe disease in XlRP with RPGR (show RPGR ELISA Kits) mutations.

  7. Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290 (show CEP290 ELISA Kits)) blindness: generation of an all-cone Nphp6 (show CEP290 ELISA Kits) hypomorph mouse that mimics the human retinal ciliopathy.

  8. Results show that the onset of renal failure in patients with IQCB1 mutations is highly variable, and that mutations are also found in Leber congenital amaurosis (LCA (show CLTA ELISA Kits)) patients without nephronophthisis, rendering IQCB1 a new gene for LCA (show CLTA ELISA Kits).

  9. Mutations in NPHP5 can cause Leber congenital amaurosis (LCA (show CLTA ELISA Kits))without early-onset renal disease.

  10. nephrocystin-5, RPGR (show RPGR ELISA Kits) and calmodulin (show CALM1 ELISA Kits) can be coimmunoprecipitated from retinal extracts, and that these proteins localize to connecting cilia of photoreceptors and to primary cilia of renal epithelial cells

IQ Motif Containing B1 (IQCB1) Antigen Profile

Antigen Summary

This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with IQCB1

  • IQ motif containing B1 (Iqcb1) antibody
  • IQ motif containing B1 (iqcb1) antibody
  • IQ motif containing B1 (IQCB1) antibody
  • IQ calmodulin-binding motif containing 1 (Iqcb1) antibody
  • 6820449I09Rik antibody
  • AV128382 antibody
  • IQCB1 antibody
  • MGC81507 antibody
  • MGC146213 antibody
  • NPHP5 antibody
  • PIQ antibody
  • SLSN5 antibody
  • zgc:101792 antibody

Protein level used designations for IQCB1

IQ calmodulin-binding motif containing 1 , IQ calmodulin-binding motif-containing protein 1 , IQ motif containing B1 , nephrocystin-5 , nphp5 , nephrocystin 5 , IQ calmodulin-binding motif-containing protein 1-like , p53 and DNA damage-regulated IQ motif protein

GENE ID SPECIES
303915 Rattus norvegicus
414609 Xenopus laevis
424242 Gallus gallus
478582 Canis lupus familiaris
494079 Danio rerio
534598 Bos taurus
715032 Macaca mulatta
745284 Pan troglodytes
780113 Xenopus (Silurana) tropicalis
100060805 Equus caballus
100409077 Callithrix jacchus
100434485 Pongo abelii
320299 Mus musculus
9657 Homo sapiens
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