anti-IQ Motif Containing B1 (IQCB1) Antibodies

IQCB1 encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. Additionally we are shipping IQ Motif Containing B1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IQCB1 303915  
IQCB1 320299 Q8BP00
IQCB1 9657 Q15051
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Top anti-IQ Motif Containing B1 Antibodies at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IQCB1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human heart WB Suggested Anti-IQCB1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using Nephrocystin-5 Polyclonal Antibody. 100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from K562 cells, using IQCB1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB IQCB1 Antibody (Center)  western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the IQCB1 antibody detected the IQCB1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry (IHC) analyzes of Nephrocystin-5 antibody in paraffin-embedded human colon carcinoma tissue. Western blot (WB) analysis of Nephrocystin-5 antibody in extracts from K562 cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Nephrocystin 5 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Nephrocystin 5 expression in Ramos (A), HeLa (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 7 to 9 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: IQCB1 Antibody [NBP2-14126] - Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli, cytoskeleton (microtubules) & cytoskeleton (cytokinetic bridge). Immunohistochemistry-Paraffin: IQCB1 Antibody [NBP2-14126] - Staining of human colon shows moderate cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details

IQCB1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Mouse (Murine)


Human
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More Antibodies against IQ Motif Containing B1 Interaction Partners

Mouse (Murine) IQ Motif Containing B1 (IQCB1) interaction partners

  1. Nphp5(-/-) photoreceptor degeneration was complete at 1 mo of age but was delayed significantly in Nphp5(-/-);Nrl(-/-) (cone only) retina

  2. Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290 (show CEP290 Antibodies)) blindness: generation of an all-cone Nphp6 (show CEP290 Antibodies) hypomorph mouse that mimics the human retinal ciliopathy.

Human IQ Motif Containing B1 (IQCB1) interaction partners

  1. that nephrocystin-5 is essential for photoreceptor outer segment formation

  2. Dynamic ubiquitination and deubiquitination of NPHP5 plays a crucial role in the regulation of ciliogenesis. NPHP5 directly binds to a deubiquitinating enzyme USP9X/FAM and two E3 ubiquitin ligases BBS11/TRIM32 and MARCH7/axotrophin.

  3. NPHP5-mutant dogs recapitulate the human phenotype of very early loss of rods, and relative retention of the central retinal cone photoreceptors that lack function.

  4. NPHP5 and Cep290 (show CEP290 Antibodies) regulate BBSome integrity, ciliary trafficking and cargo delivery.

  5. High-throughput mutation analysis identified a homozygous truncating mutation (c.1504C>T, p.R502*) in the NPHP5 in 5 families in Iranian children with nephronophthisis.

  6. mutation is predicted to introduce a new open reading frame that results in the truncation of the C-terminal 235 amino acids of nephrocystin-5 and its consequent loss of function

  7. NPHP5 mutations impair protein interaction with Cep290 (show CEP290 Antibodies) and localize to centrosomes, thereby compromising cilia formation.

  8. in a set of consanguineous patient families with Leber congenital amaurosis study identified five putative disease-causing mutations, including four novel alleles, in six families; These five mutations are located in four genes, ALMS1 (show ALMS1 Antibodies), IQCB1, CNGA3 (show CNGA3 Antibodies), and MYO7A (show MYO7A Antibodies)

  9. Data show that the minor allele (N) of I393N in IQCB1 and the common allele (R) of R744Q in RPGRIP1L (show RPGRIP1L Antibodies) were associated with severe disease in XlRP with RPGR (show RPGR Antibodies) mutations.

  10. Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290 (show CEP290 Antibodies)) blindness: generation of an all-cone Nphp6 (show CEP290 Antibodies) hypomorph mouse that mimics the human retinal ciliopathy.

IQ Motif Containing B1 (IQCB1) Antigen Profile

Protein Summary

This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with IQCB1

  • IQ motif containing B1 (Iqcb1) antibody
  • IQ motif containing B1 (iqcb1) antibody
  • IQ motif containing B1 (IQCB1) antibody
  • IQ calmodulin-binding motif containing 1 (Iqcb1) antibody
  • 6820449I09Rik antibody
  • AV128382 antibody
  • IQCB1 antibody
  • MGC81507 antibody
  • MGC146213 antibody
  • NPHP5 antibody
  • PIQ antibody
  • SLSN5 antibody
  • zgc:101792 antibody

Protein level used designations for IQCB1

IQ calmodulin-binding motif containing 1 , IQ calmodulin-binding motif-containing protein 1 , IQ motif containing B1 , nephrocystin-5 , nphp5 , nephrocystin 5 , IQ calmodulin-binding motif-containing protein 1-like , p53 and DNA damage-regulated IQ motif protein

GENE ID SPECIES
303915 Rattus norvegicus
414609 Xenopus laevis
424242 Gallus gallus
478582 Canis lupus familiaris
494079 Danio rerio
534598 Bos taurus
715032 Macaca mulatta
745284 Pan troglodytes
780113 Xenopus (Silurana) tropicalis
100060805 Equus caballus
100409077 Callithrix jacchus
100434485 Pongo abelii
320299 Mus musculus
9657 Homo sapiens
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