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Iduronate 2-Sulfatase Proteins (IDS)

Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Additionally we are shipping IDS Antibodies (83) and IDS Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDS 3423 P22304
IDS 15931 Q08890
Rat IDS IDS 363513  
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Top IDS Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$823.90
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$952.01
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

IDS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Top referenced IDS Proteins

  1. Human IDS Protein expressed in Human Cells - ABIN2002610 : Wilson, Morris, Anson, Occhiodoro, Bielicki, Clements, Hopwood: Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 3 references for ABIN2002610

More Proteins for Iduronate 2-Sulfatase (IDS) Interaction Partners

Zebrafish Iduronate 2-Sulfatase (IDS) interaction partners

  1. Data demonstrate that iduronate sulfatase plays a critical role during early vertebrate development and its downregulation may be responsible for severe developmental defects, including a misshapen trunk and abnormal craniofacial cartilages.

Human Iduronate 2-Sulfatase (IDS) interaction partners

  1. This study evaluated a novel mutation in the IDS gene among 8 male Hunter syndrome patients; there was a quantitative deficiency of NK and B cell with normal responses in other immune parameters.

  2. 30 novel iduronate sulfatase mutations have been identified in mucopolysaccharidosis type II Latin American patients.

  3. Identification of a splice site mutation in the IDS gene associated with mucopolysaccharidosis type II.

  4. a novel (p.R468P) and five known (p.R88C, p.D148V, p.G224A, p.Y348X, and p.R468Q) IDS mutations were shown to result in proteins with little or no IDS activity and altered protein processing, when expressed in COS7 cells

  5. A report of a novel IDS nonsense mutation resulting in mucopolysaccharidosis type II in several patients from a Chinese family.

  6. genetically analyze patients with severe Hunter syndrome that showed a total deletion of the iduronate-2-sulphatase (IDS) gene

  7. Family members with 3 generations of X-inactivation with Hunter syndrome have 1568A>G missence mutation in the IDS gene

  8. LCR (show CBR2 Proteins)-initiated rearrangements at the IDS locus, completed with Alu-mediated recombination or non-homologous end joining

  9. Hunter syndrome in Thailand is caused by a diverse set of defects affecting both IDS protein production and activity.

  10. The in vivo correction of heritable gene lesions at the RNA level operating via a correction mechanism akin to RNA-editing, was observed for IDS mutant transcript.

Mouse (Murine) Iduronate 2-Sulfatase (IDS) interaction partners

  1. While the iduronate 2-sulfatase sp replacement results in increased enzyme secretion, the addition of the ApoB (show APOB Proteins)-BD allows efficient BBB transcytosis and restoration of sulphamidase (show SGSH Proteins) activity in the brain of treated mice.

  2. Iduronate-2-sulfatase (IDS) is localized in lysosomes in pancreatic islet cells and expression is regulated by glucose. IDS has a potential role in the normal pathway of lysosomal degradation of secretory peptides.

  3. Ids crossing the blood-brain barrier corrects CNS defects in MPSII mice.

IDS Protein Profile

Protein Summary

Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.

Gene names and symbols associated with Iduronate 2-Sulfatase Proteins (IDS)

  • iduronate 2-sulfatase (IDS)
  • iduronate 2-sulfatase (CpipJ_CPIJ004938)
  • iduronate 2-sulfatase (ids)
  • iduronate 2-sulfatase (Ids)
  • AW214631 protein
  • MPS2 protein
  • SIDS protein
  • zgc:158245 protein

Protein level used designations for Iduronate 2-Sulfatase Proteins (IDS)

iduronate 2-sulfatase (Hunter syndrome) , iduronate-2-sulfatase , iduronate 2-sulfatase , iduronate 2-sulfatase-like , alpha-L-iduronate sulfate sulfatase , iduronate 2-sulfatase 14 kDa chain , iduronate 2-sulfatase 42 kDa chain , idursulfase , iduronate sulfatase

GENE ID SPECIES
465896 Pan troglodytes
492194 Canis lupus familiaris
541272 Bos taurus
700892 Macaca mulatta
6036406 Culex quinquefasciatus
100135738 Xenopus (Silurana) tropicalis
100356659 Oryctolagus cuniculus
100415225 Callithrix jacchus
100435640 Pongo abelii
100469837 Ailuropoda melanoleuca
559959 Danio rerio
3423 Homo sapiens
15931 Mus musculus
363513 Rattus norvegicus
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