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The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Additionally we are shipping ICT1 Antibodies (65) and ICT1 Kits (3) and many more products for this protein.
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ICT1 knockdown significantly inhibited cell proliferation and migration, led to G2/M phase cell-cycle arrest, and triggered apoptosis via the intracellular AMPKa, SAPK (show MAPK9 Proteins)/JNK (show MAPK8 Proteins), and PARP signaling pathways.
ICT1 was significantly upregulated in diffuse large B-cell lymphoma tissues (DLBCL) and correlated with poor survival. Knockdown of ICT1 remarkably induced cell cycle G0/G phase arrest and apoptosis in DLBCL cells.
ICT1 knockdown altered the expression of apoptosis- or cell cyclerelated proteins such as Bcl-2 (show BCL2 Proteins), caspase-3 (show CASP3 Proteins), CDK1 (show CDK1 Proteins), CDK2 (show CDK2 Proteins) and cyclin B.
ICT1 may be essential for hydrolysis of prematurely terminated peptidyl-tRNA moieties in stalled mitoribosomes.
Because ICT1 is essential in human cells, these results suggest that ribosome rescue activity in mitochondria is required in humans
solution structure of the catalytic domain of the ICT1 protein that lacks an N-terminal mitochondrial targeting signal and an unstructured C-terminal basic-residue-rich extension
The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. One potential marker is ICT1 whose mRNA and protein were more highly expressed in undifferentiated than in differentiated cells.
immature colon carcinoma transcript 1
, Immature colon carcinoma transcript 1
, Immature colon carcinoma transcript 1 protein homolog
, Peptidyl-tRNA hydrolase ICT1, mitochondrial
, digestion substraction 1
, immature colon carcinoma transcript 1 protein
, peptidyl-tRNA hydrolase ICT1, mitochondrial
, immature colon carcinoma transcript 1 protein homolog