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Immediate Early Response 3 Proteins (IER3)

IER3 functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Additionally we are shipping IER3 Antibodies (45) and IER3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IER3 8870 P46695
IER3 15937  
Rat IER3 IER3 294235  
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Top IER3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,042.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$388.93
Details

IER3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Immediate Early Response 3 (IER3) Interaction Partners

Human Immediate Early Response 3 (IER3) interaction partners

  1. interleukin-1beta (IL-1beta (show IL1B Proteins))-induced IER3 expression is mediated by the ERK1/2 target, transcription factor Elk-1 (show ELK1 Proteins).

  2. findings suggest that IER3 is a putative tumor suppressor in the cervix, and the c-Ab1/p73beta/IER3 axis is a novel and crucial signaling pathway that confers etoposide chemosensitivity.

  3. High expression of IER3 is associated with hepatocarcinoma.

  4. In human samples removed from failed AVF, there was a significant increase in IEX-1 expression localized to the adventitia.

  5. IEX-1 expression levels correlate with the severity of preeclampsia

  6. Studied the binding effect of hcmv-miR (show MLXIP Proteins)-UL148D to the 3' untranslated region (3'UTR) of IEX-1.Results showed that only one binding site in the 3'UTR of IEX-1 was completely complementary to an 11nt sequence in the 5' terminus of hcmv-mir (show MLXIP Proteins)-UL148D.

  7. the interference of IER3 with the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)-Fyn (show FYN Proteins) pathway represents a novel mechanism of Nrf2 (show GABPA Proteins) regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.

  8. IEX-1 plays a role in suppression of apoptosis and protects cells by controlling sensitivity to TNFalpha (show TNF Proteins) under both normal and inflammatory conditions.

  9. Altered IEX-1 expression can potentially be a new predictor of the malignant transformation and a prognostic indicator for cancer therapy.

  10. Changes of methylation status of gene IEX-1 promoter CpG island correlates with hematologic malignancies.

Mouse (Murine) Immediate Early Response 3 (IER3) interaction partners

  1. these results indicate that IER3 is a key player in expanding the pool of APC (show APC Proteins) while highlighting the role of distinct effectors found in an obese microenvironment in this process

  2. Loss of IEX-1 results in reduced VNH accompanied with a decrease in proliferation, reduced fibroblast, myofibroblast, and Ly6C staining accompanied with increased apoptosis mediated through a reduction in Vegf-A (show VEGFA Proteins)/Mcp-1 (show CPT1B Proteins) axis and Mmp-9 (show MMP9 Proteins).

  3. IER3 supports KRASG12D-associated oncogenesis in the pancreas by sustaining ERK1/2 phosphorylation via phosphatase PP2A (show PPP2R2B Proteins) inhibition.

  4. Stress-induced hematopoietic failure in the absence of immediate early (show JUN Proteins) response gene X-1 (IEX-1, IER3).

  5. the interference of IER3 with the PI3K/Akt (show AKT1 Proteins)-Fyn (show FYN Proteins) pathway represents a novel mechanism of Nrf2 (show NFE2L2 Proteins) regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.

  6. IEX-1 has a role in activation of Erk (show EPHB2 Proteins) and NF-kB pathways, which affects thrombopoietin (show THPO Proteins)-promoted NHEJ DNA repair in hematopoietic stem cells

  7. Data suggest a role for the immediate early (show JUN Proteins) response gene X-1 (IEX-1) in the control of colon epithelial homeostasis.

  8. Our present investigation shows that null mutation of IEX-1 promotes differentiation of Th17 cells but compromises the survival of Th1 (show HAND1 Proteins) cells

  9. IER3 plays a complex and to some extent contradictory role in cell cycle control and apoptosis. Effects of IER3 relate to an interference with certain signalling pathways

  10. Mcl-1 (show MCL1 Proteins) translocation to the nucleus is a general response to genotoxic stress that is strictly and timely controlled by IEX-1 in response to DNA damage. Loss of IEX-1 leads to genomic instability.

IER3 Protein Profile

Protein Summary

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.

Gene names and symbols associated with IER3

  • immediate early response 3 (IER3)
  • immediate early response 3 (Ier3)
  • AI663993 protein
  • cI-3 protein
  • DIF-2 protein
  • Dif2 protein
  • gly96 protein
  • IER3 protein
  • IEX-1 protein
  • IEX-1L protein
  • Iex1 protein
  • Ler3 protein
  • Prg1 protein

Protein level used designations for IER3

immediate early response 3 , radiation-inducible immediate-early gene IEX-1 , ATP-binding cassette, sub-family F (GCN20), member 1 , PACAP-responsive gene 1 protein , anti-death protein , differentiation-dependent gene 2 protein , expressed in pancreatic carcinoma , gly96, mouse, homolog of , immediate early protein GLY96 , immediate early response 3 protein , immediately early gene X-1 , protein DIF-2 , cAMP inducible gene 3

GENE ID SPECIES
481708 Canis lupus familiaris
505455 Bos taurus
701939 Macaca mulatta
743437 Pan troglodytes
8870 Homo sapiens
15937 Mus musculus
294235 Rattus norvegicus
462547 Pan troglodytes
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