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IER3IP1 encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Additionally we are shipping IER3IP1 Antibodies (7) and and many more products for this protein.
We expand the phenotypic spectrum of MEDS caused by IER3IP1 gene mutations and propose that WRS (show KCNQ1 ELISA Kits) and MEDS are overlapping clinical syndromes, displaying significant gene-dependent clinical variability.
Inhibiting the expression of IER3IP1 can inhibit erythroid differentiation and elevate the proliferation of K562 cells.
IER3IP1 gene expression is regulated by Sp1 (show PSG1 ELISA Kits), Sp3 (show SP3 ELISA Kits), and the TNF-a (show TNF ELISA Kits); induction of the gene in HepG2 liver cancer cell line
IER3IP1 gene was mapped to chromosome 18q12 and showed a high expression in heart, skeletal muscle and kidney, a moderate expression in liver and brain and a low expression in placenta, lung and peripheral blood leukocyte.
Matrine can inhibit the growth of K562 cells, and transiently increase the expression level of IER3IP1 gene in a dose-dependent manner.
This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12.
immediate early response 3 interacting protein 1
, immediate early response 3-interacting protein 1
, haloacid dehalogenase-like hydrolase domain-containing protein 2