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IER5 encodes a protein that is similar to other immediate early response proteins. Additionally we are shipping IER5 Antibodies (71) and IER5 Kits (1) and many more products for this protein.
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Authors propose the GCF (show GUCY2F Proteins) regulated transcriptional activity, at least in part, contributed to the upregulation of IER5 on radiation in HepG2 cells. The present findings provide insights into understanding the regulatory mechanisms of IER5.
These results reveal the existence of a novel IER5-mediated cancer regulation pathway that is responsible for the activation of HSF1 (show HSF1 Proteins) observed in various cancers.
IER5 functions as a positive feedback regulator of HSF1 (show HSF1 Proteins) and that this process involves PP2A (show PPP2R4 Proteins)/B55 (show MINK1 Proteins) and HSF1 (show HSF1 Proteins) dephosphorylation.
These observations suggest that HSF1 (show HSF1 Proteins)-mediated IER5 expression is involved in the expression of chaperone genes and in recovery from thermal stress.
Transcriptional repression mediated by IER5 regulates Cdc25B (show CDC25B Proteins) expression levels via the release of NF-YB (show NFYB Proteins) and p300 (show EP300 Proteins) in acute myeloid leukemia (show BCL11A Proteins).
the early radiation-induced expression of IER5 affects radiosensitivity via disturbing radiation-induced cell cycle checkpoints
Studies in rat found higher mRNA levels after waking and sleep deprivation for immediate early (show JUN Proteins) genes/transcription factors such as IER5
This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation.
immediate early response gene 5 protein
, immediately early response
, immediate early response 5