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CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. Additionally we are shipping Immune Receptor Expressed On Myeloid Cells 1 Proteins (17) and Immune Receptor Expressed On Myeloid Cells 1 Kits (10) and many more products for this protein.
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Mouse (Murine) Monoclonal IREM1 Primary Antibody for CyTOF, FACS - ABIN4899273
Izawa, Kitaura, Yamanishi, Matsuoka, Kaitani, Sugiuchi, Takahashi, Maehara, Enomoto, Oki, Takai, Kitamura: An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. in Journal of immunology (Baltimore, Md. : 1950) 2009
Show all 2 Pubmed References
dextran sodium sulfate-treated Cd300f-/- mice exhibit attenuated disease activity and histopathology in comparison with wild type controls
data highlight a previously unappreciated role for dendritic cells in controlling gut (show GUSB Antibodies) homeostasis and show that CD300f-dependent regulation of apoptotic cell uptake is essential for suppressing overactive dendritic cell-mediated inflammatory responses, thereby controlling the development of chronic gut (show GUSB Antibodies) inflammation.
ceramide-CD300f binding inhibits LPS (show TLR4 Antibodies)-induced skin inflammation, implicating CD300f as a negative regulator of Toll-like receptor 4 (TLR4 (show TLR4 Antibodies)) signaling in vivo
CD300lf is essential for murine noroviruse binding and replication in cell lines and primary cells.
CD300f is implicated in Wallerian degeneration and nerve regeneration by modulating both the influx and phenotype of macrophages
Y276 phosphorylation is necessary for enhanced CD300f-mediated phagocytosis through the recruitment of the p85alpha regulatory subunit of phosphatidylinositol-3-kinase
data highlight a previously unidentified role for CD300f in IL-4Ralpha-induced immune cell responses
CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis.
Several extracellular lipids (including ceramide) and lipoproteins were possible ligands for LMIR3.
We conclude that expression of CD300f conveys additional capacity to recognize phosphatidylserine to myeloid cells.
this study demonstrates the role of CD300f in governing innate immune eosinophil activities in pediatric Crohn's disease patients and in active ulcerative colitis patients
findings suggest that two rare heterozygous truncating variations (RPS24 (show RPS24 Antibodies) Q191X and CD300LF P261fsX266) are risk candidates for autism spectrum disorder.
CD300 molecules are all expressed by DC; CD300b (show TREM5 Antibodies), d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo.
The data suggest that the neuroprotective role of CD300f would be the result of a complex network of cell interactions.
peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 (show MYD88 Antibodies) and TRIF (show TRIM69 Antibodies)-mediated TLR signalling
CD300f blocked the activation of cells induced by all TLR ligands
Data indicate that CD300F is an active regulator of TLR-mediated macrophage activation through association with SHP-1 (show PTPN6 Antibodies) involving MyD88 (show MYD88 Antibodies) and/or TRIF (show TRIM69 Antibodies).
Findings indicate that IREM-1 exerted its inhibitory effect on BAFF (show TNFSF13B Antibodies)-medicated signalling through ITIM-mediated regulation of ERK (show EPHB2 Antibodies) activities in THP-1 (show GLI2 Antibodies) cells.
IgSF13 was identified from dendritic cells; preferentially expressed in myelo-monocytic cells, including monocytes, monocyte-derived DC and monocyte-related cell lines; may be involved in the negative regulation of specific leukocyte population [IgSF13]
a novel inhibitory receptor of the Ig superfamily in myeloid cells. (IREM-1 = immune receptor expressed on myeloid cells-1)
CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6\; MIM 176883) or SHIP (INPP5D\; MIM 601582) (Sui et al., 2004
CD300 antigen-like family member F
, CMRF-35-like molecule 1
, CMRF35-like molecule 1
, DC-derived Ig-like receptor 2
, leukocyte mono-Ig-like receptor 3
, myeloid-associated immunoglobulin-like receptor 5
, CD300 antigen like family member F
, CD300 molecule like family member f
, NK inhibitory receptor
, immune receptor expressed on myeloid cells 1
, immunoglobin superfamily member 13
, immunoglobulin superfamily member 13
, inhibitory receptor IREM1