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IRGM encodes a member of the p47 immunity-related GTPase family. Additionally we are shipping Immunity-Related GTPase Family, M Proteins (5) and many more products for this protein.
Showing 10 out of 76 products:
Human Polyclonal IRGM Primary Antibody for EIA, WB - ABIN500068
Massey, Parkes: Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease. in Autophagy 2007
Show all 4 references for ABIN500068
Human Polyclonal IRGM Primary Antibody for EIA, IHC (p) - ABIN500070
Fisher, Tremelling, Anderson, Gwilliam, Bumpstead, Prescott, Nimmo, Massey, Berzuini, Johnson, Barrett, Cummings, Drummond, Lees, Onnie, Hanson, Blaszczyk, Inouye, Ewels, Ravindrarajah, Keniry, Hunt et al.: Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. ... in Nature genetics 2008
Show all 4 references for ABIN500070
Human Polyclonal IRGM Primary Antibody for IHC (p), WB - ABIN655080
Che, Li, Gao, Zhang, Han, Zhang, Sun, Liu, Sun, Zhang, Ren, Tian, Li, Li, Cheng, Li: Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis. in Clinica chimica acta; international journal of clinical chemistry 2010
Show all 3 references for ABIN655080
Irgm1-/- embryonic fibroblasts show autophagic flux impairment and defective lysosomal degradation.
Interestingly, we observed that IRGM1 enhanced F-actin polymerization and triggers epithelial mesenchymal transition (EMT) through a mechanism involved in PIK3CA mediated Rac1 activation.
Interferon-beta (show IFNB1 Antibodies) activation recruited the immunity-related GTPase (show RACGAP1 Antibodies) M1 (IRGM1) to the Toxoplasma gondii-occupied parasitophorous vacuole in peritoneal macrophages and murine embryonic fibroblasts.
these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (show SH3GLB1 Antibodies)-dependent autophagy
Palmitoylation together with the alphaK helix firmly anchor Irgm1 in the Golgi and mitochondria, thus facilitating function of the protein.
2 Irgm1 isoforms generated by differential splicing localize to the Golgi apparatus & weakly to mitochondria. Only the long isoforms is seen on endolysosomal membranes. Irgm1 is a negative regulator of the immunity-related GTPase (show RACGAP1 Antibodies) protein family.
the paralogous IRGM proteins Irgm1 and Irgm3 fail to robustly associate with "non-self" PVs (show PVRL2 Antibodies) containing either the bacterial pathogen Chlamydia trachomatis or the protozoan pathogen Toxoplasma gondii
By 9 weeks post-infection, fewer Brucella abortus were recovered from LRG-47(-/-) mice than controls, suggesting that the host protein has a positive role in maintaining long term persistence of the bacteria within the host.
These results suggest that Irgm1 modulates acute inflammatory responses in the mouse intestine, putatively through the regulation of gut (show GUSB Antibodies) autophagic processes, that may be pivotal for proper Paneth cell functioning.
Loss of IRGM1 is associated with impaired CD36 internalization in macrophage, which was associated with the deficiency of F-actin polymerization in atherosclerosis.
IRGM functional polymorphisms and haplotypes in promoter were associated with the susceptibility to pulmonary tuberculosis in Chinese Hubei Han population.
In Korean children, IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset Crohn Disease as risk loci and defense loci, respectively.
The study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings.
Expression of viral protein 2C enhanced IRGM promoter activation, thereby increasing IRGM expression and inducing autophagy.
these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (show ZBTB24 Antibodies)-dependent autophagy
the IRGM(+313), an autophagy-related polymorphic locus, influences outcome in severely septic patients, with the possible involvement of autophagy in sepsis exacerbation
Results show association of IRGM gene SNPs with Crohn's disease in Indian patients and report a new mutation rs 9637876 in the IRGM gene associated with Crohn's disease.
Our findings suggest that expression of IRGM is dysregulated in gastric cancer and that the molecule may affect progression of the disease.
The IRGM rs13361189 polymorphism is promising as a biomarker for early diagnosis of Crohn's disease. However, the IRGM rs10065172 and rs4958847 polymorphisms may not be the major determinants of Crohn's disease risk.
IRGM assembles core autophagy machinery (Beclin 1 (show BECN1 Antibodies), Ulk1 (show ULK1 Antibodies), ATG16L1 (show ATG16L1 Antibodies)) and connects it with innate immunity sensors (NOD2 (show NOD2 Antibodies)) through formation of protein complex assemblies.
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.
immunity-related GTPase family M protein
, immunity-related GTPase M
, immunity-related GTPase family, M
, LPS-stimulated RAW 264.7 macrophage protein 47
, immunity-related GTPase family M protein 1
, interferon inducible protein 1
, interferon-inducible GTPase 3
, interferon-inducible protein 1
, LPS-stimulated RAW 264.7 macrophage protein 47 homolog
, LRG-47-like protein
, immunity-related GTPase family, M1