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The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Additionally we are shipping Immunoglobulin (CD79A) Binding Protein 1 Antibodies (73) and Immunoglobulin (CD79A) Binding Protein 1 Kits (7) and many more products for this protein.
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Knockdown of Alpha4 preferentially impacts the expression of PP4c (show PPP4C Proteins) and PP6c (show PPP6C Proteins) compared to expression levels of PP2Ac (show PPP2CA Proteins).
Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC (show UCN3 Proteins))-induced phosphorylation of keratin 8 (show KRT8 Proteins) (K8) via ubiquitination of protein phosphatase 2 (PP2A (show PPP2R4 Proteins)) through alpha4 phosphoprotein by caveolin-1 (cav-1 (show CAV1 Proteins)).
MID1 (show MID1 Proteins) catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 (show BBOX1 Proteins) domain disrupt polyubiquitination of alpha4 but not of PP2Ac (show PPP2CA Proteins) in X-linked Opitz syndrome.
alpha4 is an important regulatory molecule of apoptosis and Bcl-xL (show BCL2L1 Proteins) phosphorylation induced by BCR (show BCR Proteins) crosslinking.
the alpha4 N-terminus binding to endogenous PP2Ac (show PPP2CA Proteins) and PABP (show PABPC1 Proteins), and the C-terminus to EDD, is reported.
A potential important role of alpha4 in control of cell migration and/or invasion via the regulation of E-cadherin (show CDH1 Proteins) expression in bladder urothelial carcinoma.
The structure of alpha45 reveals two distinct surfaces, one that can interact with a negatively charged surface, which is present on PP2A (show PPP2R4 Proteins), and one that interacts with the Bbox1 (show BBOX1 Proteins) domain of MID1 (show MID1 Proteins).
both the C-terminal Mid1 (show MID1 Proteins)-binding domain and the PP2Ac (show PPP2CA Proteins)-binding determinants are required for Alpha4-mediated protection of PP2Ac (show PPP2CA Proteins) from polyubiquitination and degradation.
IGBP-1 is expressed universally in advanced lung adenocarcinomas, and its overexpression is significantly related to outcome.
Data show that in addition to PP2Ac (show PPP2CA Proteins), alpha4 interacts with EDD and PABP (show PABPC1 Proteins), suggesting its involvement in multiple steps in the mTOR (show FRAP1 Proteins) pathway that leads to translation initiation and cell-cycle progression.
results show that alpha4, a noncatalytic subunit of protein phosphatase 2A, is required to repress apoptosis in murine cells
alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A (show PPP2R2B Proteins) and PP6
Alpha4 (Igbp1) plays a required role in regulating the assembly and maintenance of adaptive PP2A (show PPP2R2B Proteins) phosphatase complexes.
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.
immunoglobulin-binding protein 1
, immunoglobulin (CD79A) binding protein 1
, immunoglobulin binding protein 1
, ROD1 regulator of differentiation 1
, B cell signal transduction molecule alpha 4
, B-cell signal transduction molecule alpha 4
, CD79a-binding protein 1
, bA351K23.1 (immunoglobulin binding protein 1 (CD79A) )
, protein alpha-4
, protein phosphatase 2/4/6 regulatory subunit
, protein phosphatase 2A, regulatory subunit alpha-4
, renal carcinoma antigen NY-REN-16
, alpha 4
, alpha4 phosphoprotein
, lymphocyte signal transduction molecule alpha 4
, phosphoprotein, component, 52 kDa