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anti-Immunoglobulin Associated alpha (IgA) Antibodies

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Additionally we are shipping Immunoglobulin Associated alpha Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IgA 12518 P11911
IgA    
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Top anti-Immunoglobulin Associated alpha Antibodies at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Reactivity Host Conjugate Application Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated 100 μg Log in to see 9 to 19 Days
$558.62
Details
Mouse Rabbit Un-conjugated 100 μg Log in to see 9 to 19 Days
$558.62
Details

IgA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)

Human

More Antibodies against Immunoglobulin Associated alpha Interaction Partners

Mouse (Murine) Immunoglobulin Associated alpha (IgA) interaction partners

  1. BCR (show BCR Antibodies) activation is accompanied by asymmetric conformational changes, possibly promoting the binding of Igalpha and Igbeta to differently localized signaling complexes

  2. CD79a (show CD79A Antibodies) myeloid cells showed enhanced ability to promote primary tumor growth and metastasis.

  3. Data indicate that in the absence of DGKzeta (show DGKZ Antibodies), the threshold for B cell antigen receptor (BCR (show BCR Antibodies)) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK (show EPHB2 Antibodies)) pathway, was markedly reduced in mature follicular B cells.

  4. Data show that the B cell antigen receptor (BCR (show BCR Antibodies)) and Igalpha may be required for B cell survival because they function as adaptor proteins in a BAFFR (show TNFRSF13C Antibodies) signaling pathway leading to activation of Syk (show SYK Antibodies), indicating crosstalk between the two receptors.

  5. The mouse B cell-specific mb-1 (show PSMB5 Antibodies) gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.

  6. endocytosed BCR (show BCR Antibodies) sequentially regulates MAPK (show MAPK1 Antibodies) and Akt (show AKT1 Antibodies) signaling pathways from intracellular compartments

  7. Arginine 198 in the tail of the Igalpha subunit of the BCR (show BCR Antibodies) is methylated by the protein arginine methyltransferase 1 (show PRMT1 Antibodies). Methylation negatively regulates the calcium and PI-3 (show PI3 Antibodies) kinase pathways of the BCR (show BCR Antibodies), promoting signals leading to B (show TDO2 Antibodies) cell differentiation.

  8. The direct recruitment of BLNK (show BLNK Antibodies) to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways

  9. IgA deficiency in lymphotoxin-deficient (LT(-/-)) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs.

  10. The VHDJH recombination process at the IgH locus and the survival of pro-B cells that carry these rearrangements do not depend on the expression of Ig-alpha molecules.

Immunoglobulin Associated alpha (IgA) Antigen Profile

Protein Summary

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Gene names and symbols associated with IgA

  • CD79A antigen (immunoglobulin-associated alpha) (Cd79a) antibody
  • Ig-alpha antibody
  • Iga antibody
  • Igalpha antibody
  • Ly-54 antibody
  • Ly54 antibody
  • mb-1 antibody

Protein level used designations for IgA

B-cell antigen receptor complex-associated protein alpha chain , Ig alpha , MB-1 membrane glycoprotein , immunoglobulin-associated alpha , membrane-bound immunoglobulin-associated protein , surface IgM-associated protein

GENE ID SPECIES
12518 Mus musculus
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