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Serves to link two monomer units of either IgM or IgA. Additionally we are shipping IGJ Proteins (8) and IGJ Kits (5) and many more products for this protein.
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TLR2 ligands induce CCR9 and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells.
Data show that Crlz1 (show UTP3 Antibodies) increased the IgJ enhancer activity due to its CBF (show CEBPZ Antibodies) sites, as verified by both the absence of Crlz1 (show UTP3 Antibodies) effect on the CBF (show CEBPZ Antibodies)-site mutated IgJ enhancer and the presence of transcriptional synergy between Crlz1 (show UTP3 Antibodies) and CBFbeta (show CBFB Antibodies).
identifies the HSS3/4 enhancer of Crlz1 (show UTP3 Antibodies)-IgJ locus as another target of EBG in early developmental stage of B cells
H3 and H4 histones toward the chromatin of the Crlz1 (show UTP3 Antibodies) gene are found to be hyperacetylated, especially on H3, in the pre-B cells, whereas those toward the chromatin of the IgJ gene are found to be hyperacetylated in the plasma cells
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
immunoglobulin J chain
, mu- and alpha-immunoglobulin-associated J chain
, IgJ chain
, J chain
, immunoglobulin joining gene (not J region)