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Immunoglobulin Superfamily, Member 8 Proteins (IGSF8)

IGSF8 encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Additionally we are shipping IGSF8 Antibodies (62) and IGSF8 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IGSF8 93185 Q969P0
IGSF8 140559 Q8R366
Rat IGSF8 IGSF8 304979  
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Top IGSF8 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK293 Human His tag   500 μg Log in to see 5 Days
$1,732.50
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

IGSF8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine) , ,
, ,

More Proteins for Immunoglobulin Superfamily, Member 8 (IGSF8) Interaction Partners

Human Immunoglobulin Superfamily, Member 8 (IGSF8) interaction partners

  1. EWI-2 negatively regulates TGF-beta (show TGFB1 Proteins) signaling and its downstream events including cytostasis (in vitro and in vivo), EMT (show ITK Proteins)-like changes, cell migration, CD271 (show NGFR Proteins)-dependent invasion, and lung metastasis (in vivo).

  2. Authors demonstrated that EWI-2wint promotes CD81 (show CD81 Proteins) clustering and confinement in CD81 (show CD81 Proteins)-enriched areas.

  3. The EWI-2/alpha-actinin complex is involved in regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and the formation of polarized membrane structures involved in T cell recognition.

  4. analysis of interacting regions of CD81 (show CD81 Proteins) and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection

  5. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 (show CD82 Proteins) and inhibits the migration of prostate cancer cells.

  6. EWI-2-dependent reorganization of alpha4beta1-CD81 (show CD81 Proteins) complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions

  7. EWI proteins EWI-2 and EWI-F (show PTGFRN Proteins), alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 (show CD9 Proteins) organization

  8. EWI-2 and EWI-F (show PTGFRN Proteins) link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin (show MSN Proteins) proteins

  9. Important functions of recently activated dendritic cells are thus critically modulated by the newly discovered HSPA8 (show HSPA8 Proteins)-EWI-2 interaction.

  10. CD81 (show CD81 Proteins) partner EWI-2wint inhibits hepatitis C virus entry [EWI-2wint]

Mouse (Murine) Immunoglobulin Superfamily, Member 8 (IGSF8) interaction partners

  1. IgSF8 is present in developing olfactory sensory neuron synapses, and it interacts with Tspan CD9 (show CD9 Proteins).

  2. Igsf8-deficient eggs retain the normal level and localization of CD9 (show CD9 Proteins), resulting in normal microvilli formation indicating that IGSF8 is dispensable in fertility.

  3. This study showed that the EWI2 cytoplasmic tail actively engages with the cell membrane via phosphatidylinositol phosphate binding and palmitoylation.

  4. Igsf8 is first expressed at E9.5 in a ventral domain of the neural tube, with dorsal expression apparent at E10.5.. From E11.5, Igsf8 occurs at the edge of the ventricular zone, in postmitotic neuroblasts, and in sensory ganglia.

  5. EWI-2 and EWI-F (show PTGFRN Proteins) link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin (show MSN Proteins) proteins

  6. Report that the expression level of EWI-2 on the Cd9 (show CD9 Proteins)(-/-) oocyte surface is <10% of the wild-type level. Hence, the severe reduction in EWI-2 activity may be responsible for the loss of fusion ability.

  7. Immunoglobulin superfamily member (show CDON Proteins) IgSF8 (EWI-2) and CD9 (show CD9 Proteins) in fertilisation: evidence of distinct functions for CD9 (show CD9 Proteins) and a CD9 (show CD9 Proteins)-associated protein in mammalian sperm-egg interaction.

IGSF8 Protein Profile

Protein Summary

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with IGSF8

  • zgc:77222 (zgc:77222)
  • immunoglobulin superfamily, member 8 (IGSF8)
  • immunoglobulin superfamily, member 8 (LOC100338663)
  • immunoglobulin superfamily, member 8 (Igsf8)
  • AA033172 protein
  • AU041109 protein
  • CD81P3 protein
  • CD316 protein
  • ESTM34 protein
  • EWI-2 protein
  • EWI2 protein
  • IGSF8 protein
  • KCT-4 protein
  • LIR-D1 protein
  • MGC77222 protein
  • MGC151661 protein
  • PGRL protein
  • R75384 protein

Protein level used designations for IGSF8

immunoglobulin superfamily member 8 , immunoglobulin superfamily, member 8 , immunoglobulin superfamily member 8-like , CD81 partner 3 , glu-Trp-Ile EWI motif-containing protein 2 , keratinocytes-associated transmembrane protein 4 , prostaglandin regulatory-like protein , PG regulatory-like protein , keratinocyte-associated transmembrane protein 4

GENE ID SPECIES
404631 Danio rerio
469549 Pan troglodytes
519266 Bos taurus
100058209 Equus caballus
100154024 Sus scrofa
100338663 Oryctolagus cuniculus
100441861 Pongo abelii
100595459 Nomascus leucogenys
93185 Homo sapiens
140559 Mus musculus
304979 Rattus norvegicus
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