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anti-Immunoglobulin kappa Variable 1-27 (IGKV1-27) Antibodies

IGKV1-27 was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF).

list all antibodies Gene Name GeneID UniProt
IGKV1-27 7128 P21580
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Top anti-Immunoglobulin kappa Variable 1-27 Antibodies at

Showing 6 out of 7 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB A20 mAb tested by Western blot. Detection of A20 by Western blot. A20 can be detected in Daudi whole-cell extract at 3 µg/ml. 100 μg Log in to see 1 to 2 Days
Human Rabbit Un-conjugated ELISA, IF, WB Western Blot (WB) analysis of specific cells using A20 Polyclonal Antibody. 100 μL Log in to see 14 Days
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of A20 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of A20 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
Human Rabbit Un-conjugated ELISA, WB Western Blot (WB) analysis of 3T3 using A20 antibody. 100 μL Log in to see 14 Days
Human Mouse Un-conjugated WB   50 μg Log in to see 6 Days
Human Rabbit Un-conjugated   100 μL Log in to see 9 to 14 Days

IGKV1-27 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)

Rat (Rattus)

Top referenced anti-Immunoglobulin kappa Variable 1-27 Antibodies

  1. Human Monoclonal IGKV1-27 Primary Antibody for WB - ABIN2668824 : Wu, Xu, Chang: The promyelocytic leukemia protein represses A20-mediated transcription. in The Journal of biological chemistry 2002 (PubMed)

More Antibodies against Immunoglobulin kappa Variable 1-27 Interaction Partners

Human Immunoglobulin kappa Variable 1-27 (IGKV1-27) interaction partners

  1. There is a significantly higher occurrence of the A20 (show TNFAIP3 Antibodies) rs143002189 polymorphism in diffuse large B cell lymphoma (DLBCL) compared to non-neoplastic controls and other types of B cell malignancies.

  2. HMBA was able to increase prostratin-induced phosphorylation and degradation of NF-kappaB (show NFKB1 Antibodies) inhibitor IkappaBalpha (show NFKBIA Antibodies), thereby enhancing and prolonging prostratin-induced nuclear translocation of NF-kappaB (show NFKB1 Antibodies), a prerequisite for stimulation of transcription initiation

  3. A Japanese family case with juvenile onset Behcet's disease caused by TNFAIP3 (show TNFAIP3 Antibodies) mutation.

  4. TNFAIP3 gene polymorphisms (rs9494885 and rs7753873) are associated with the susceptibility to allergic rhinitis in the Chinese Han population.

  5. A20 (show TNFAIP3 Antibodies) significantly inhibited poly(I:C)-induced cytokine production, and this effect was related to the inhibition of NF-kappaB (show NFKB1 Antibodies) signaling. These results suggest that the downregulation of A20 (show TNFAIP3 Antibodies) increased the susceptibility of keratinocytes to external stimuli, thus contributing to the development of psoriasis.

  6. we indentified 13 susceptibility SNPs and a long risk haplotype for SLE at TNFAIP3 gene locus. Our results suggest that TNFAIP3 is a susceptible gene for SLE in Han Chinese population.

  7. By using bioinformatics analysis tool (Targetscan), the 3' untranslated region (3'UTR (show UTS2R Antibodies)) of A20 (show TNFAIP3 Antibodies) gene was found to be a target of miR (show MLXIP Antibodies)-125a. The expression level of miR (show MLXIP Antibodies)-125a in pancreatic cancer tissues from chemo-sensitive patients was significantly lower than that from chemo-resistant patients, and was inversely correlated with the A20 (show TNFAIP3 Antibodies) mRNA.

  8. Data suggest an association of TNFAIP3 (show TNFAIP3 Antibodies) SNPs with susceptibility to chronic ITP (show ITPA Antibodies). Together with previous reports, finding provides further evidence for TNFAIP3 (show TNFAIP3 Antibodies) being a general autoimmunity gene.

  9. we identify the single nucleotide polymorphism rs2327832 of TNFAIP3 (show TNFAIP3 Antibodies) as a possible prognostic marker for diabetes outcome in children with T1D.

  10. A20 (show TNFAIP3 Antibodies) acts as a regulator of the ectodysplasin-A1 (show EDA Antibodies) pathway to NF-kappaB (show NFKB1 Antibodies) activation in primary Sjogren's syndrome salivary glands epithelial cells

Immunoglobulin kappa Variable 1-27 (IGKV1-27) Antigen Profile

Protein Summary

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with IGKV1-27

  • tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) antibody
  • A20 antibody
  • OTUD7C antibody
  • TNFA1P2 antibody

Protein level used designations for IGKV1-27

OTU domain-containing protein 7C , TNF alpha-induced protein 3 , putative DNA-binding protein A20 , tumor necrosis factor alpha-induced protein 3 , tumor necrosis factor inducible protein A20 , zinc finger protein A20

7128 Homo sapiens
Selected quality suppliers for anti-Immunoglobulin kappa Variable 1-27 (IGKV1-27) Antibodies
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