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Translational regulator that ensures constant high levels of translation under amino acid starvation. Additionally we are shipping IMPACT Antibodies (26) and many more products for this protein.
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Data suggest that high expression of protein IMPACT homolog in non-immune cells acts as a protective mechanism against indoleamine 2,3-dioxygenase (IDO (show IDO1 Proteins))-induced GCN2 (show EIF2AK4 Proteins) activation, making them resistant to the amino acid-deprived environment caused by IDO (show IDO1 Proteins).
This study extends our understanding of the roles played by GCN1 in GCN2 (show EIF2AK4 Proteins) activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha (show EIF2A Proteins) kinase.
the participation of the GCN2-IMPACT module of translational regulation in a highly controlled step in the development of the nervous system.
IMPACT ensures constant high levels of translation and low levels of CREB-2 (show ATF4 Proteins) and GADD53 in specific neuronal cells under amino acid starvation conditions.
Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity).
imprinted and ancient
, imprinted and ancient gene protein homolog
, protein IMPACT
, Impact homolog (mouse)
, protein IMPACT-A
, imprinted and ancient gene protein homolog A
, Impact homolog
, RWD domain containing 5
, imprinted and ancient gene protein