Importin 8 (IPO8) ELISA Kits

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Additionally we are shipping Importin 8 Antibodies (34) and Importin 8 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human IPO8 IPO8 10526 O15397
Anti-Mouse IPO8 IPO8 320727 Q7TMY7
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More ELISA Kits for Importin 8 Interaction Partners

Human Importin 8 (IPO8) interaction partners

  1. the findings of the present study provided novel insights into the control of IPO8 transcription, and may enhance understanding regarding RUNX2 (show RUNX2 ELISA Kits) regulatory mechanisms in osteoblast differentiation, bone development, and degenerative bone disease.

  2. Our studies also suggest that nuclear entry is important for the prooncogenic activity of eIF4E (show EIF4E ELISA Kits), at least in this context. These findings position nuclear trafficking of eIF4E (show EIF4E ELISA Kits) as a critical step in its regulation and position the importin 8-eIF4E (show EIF4E ELISA Kits) complex as a novel therapeutic target.

  3. importin alpha8 functions as a cNLS receptor with distinct cargo specificity, and that heterodimerization by importin alpha8 is a novel regulatory mode of cNLS binding, in addition to the autoinhibitory regulation by the importin beta (show KPNB1 ELISA Kits) binding domain.

  4. Knockdown of IPO8 reduced the amount of nuclear p65 (show GORASP1 ELISA Kits) following TNF (show TNF ELISA Kits) stimulation. IPO8 binding to p65 (show GORASP1 ELISA Kits) is NLS (show ALDH1A2 ELISA Kits) independent.

  5. TGF-beta (show TGFB1 ELISA Kits)-induced and basal state spontaneous nuclear import of Smad4 (show SMAD4 ELISA Kits) require importin 7 (show IPO7 ELISA Kits) and 8.

  6. IPO8 is the most accurate reference gene for clinical lung specimens.

  7. Study provides evidence that Imp8 is required for cytoplasmic miRNA-guided gene silencing and affects nuclear localization of Ago proteins.

Mouse (Murine) Importin 8 (IPO8) interaction partners

  1. Importin 8 plays a critical role in mediating the cytoplasm-to-nucleus transport of mature miRNAs. IPO8-mediated nuclear transport of mature miRNAs is also dependent on the association of IPO8 with the Argonaute 2 (show EIF2C2 ELISA Kits) complex.

Importin 8 (IPO8) Antigen Profile

Antigen Summary

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Importin 8 (IPO8) ELISA Kits

  • importin 8 (IPO8) antibody
  • importin 8 (ipo8) antibody
  • importin 8 (Ipo8) antibody
  • 6230418K12Rik antibody
  • Abcc10 antibody
  • C130009K11Rik antibody
  • IPO8 antibody
  • MRP7 antibody
  • OM-1 antibody
  • Om1 antibody
  • Ranbp8 antibody
  • si:ch211-116i17.1 antibody

Protein level used designations for Importin 8 (IPO8) ELISA Kits

importin 8 , importin-8 , RAN binding protein 8 , imp8 , ran-binding protein 8 , ATP-binding cassette, sub-family C (CFTR/MRP), member 10 , oocyte maturation 1

418142 Gallus gallus
473395 Pan troglodytes
523408 Bos taurus
555520 Danio rerio
612863 Canis lupus familiaris
10526 Homo sapiens
320727 Mus musculus
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