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Imprintor 1 Proteins (IMP1)

The protein encoded by IMP1, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. Additionally we are shipping Imprintor 1 Antibodies (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IMP1 81502 Q8TCT9
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Top Imprintor 1 Proteins at antibodies-online.com

Showing 1 out of 1 products:

Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 5 Days
$522.50
Details

IMP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

More Proteins for Imprintor 1 (IMP1) Interaction Partners

Human Imprintor 1 (IMP1) interaction partners

  1. structure of human SPP [SPP]

  2. identified human signal peptide peptidase as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases [SPP]

  3. identification and molecular cloning; expression analysis of the hIMP1 gene (located on chromosome 20) was performed in human cell tissues and transfected cell cultures [IMP1 (show IMPA1 Proteins)]

  4. widespread expression of SPP in many tissues

  5. signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

  6. IMP1 (show IMPA1 Proteins) is a bi-aspartic polytopic protease capable of cleaving transmembrane proteins such as presenilin 2 (show PSEN2 Proteins).

  7. The peptide structure corresponding to the C-terminal residues from H13 ribosomal protein was determined using magnetic resonance spectroscopy.

  8. SPP, SPPL2a (show SPPL2A Proteins), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  9. data implicate SPP in the US2 pathway and indicate the possibility of a previously unknown function for this intramembrane-cleaving aspartic protease in dislocation from the endoplasmic reticulum

  10. Upon isolation of membranes and solubilization with detergent, the biochemical characteristics of SPP are remarkably similar to gamma-secretase.

Imprintor 1 (IMP1) Protein Profile

Protein Summary

The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.

Gene names and symbols associated with Imprintor 1 Proteins (IMP1)

  • histocompatibility (minor) 13 (HM13)
  • dJ324O17.1 protein
  • H13 protein
  • IMP1 protein
  • IMPAS protein
  • IMPAS-1 protein
  • MSTP086 protein
  • PSENL3 protein
  • PSL3 protein
  • SPP protein
  • SPPL1 protein

Protein level used designations for Imprintor 1 Proteins (IMP1)

IMP-1 , hIMP1 , intramembrane protease 1 , minor histocompatibility antigen 13 , minor histocompatibility antigen H13 , presenilin-like protein 3 , signal peptide peptidase beta , signal peptide peptidase like 1

GENE ID SPECIES
81502 Homo sapiens
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