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Indoleamine 2,3-Dioxygenase 2 Proteins (IDO2)

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011].. Additionally we are shipping IDO2 Antibodies (101) and IDO2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDO2 169355 Q6ZQW0
IDO2 681319  
IDO2 209176  
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Top IDO2 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
$660.00
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$826.12
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

IDO2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Rat (Rattus)

Mouse (Murine)

More Proteins for Indoleamine 2,3-Dioxygenase 2 (IDO2) Interaction Partners

Human Indoleamine 2,3-Dioxygenase 2 (IDO2) interaction partners

  1. functional importance of IDO (show IDO1 Proteins) enzymes in human Crohn's disease

  2. Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1 (show IDO1 Proteins)

  3. These results demonstrate that IDO2 plays a novel role as a negative regulator of IDO1 (show IDO1 Proteins) by competing for heme-binding with IDO1 (show IDO1 Proteins).

  4. The IDO2 is now known to catalyze the first and rate-limiting step in the catabolism of tryptophan along a relative newcomer to the kynurenine pathway field.

  5. Multiple-scattering (MS) analysis of EXAFS data on met-indoleamine 2,3-dioxygenase-2 (IDO2) and analysis of XANES have provided the first direct structural information about the axial donor ligands of the iron center for this recently discovered protein.

  6. IDO2 is expressed in both mDCs and plasmacytoid DCs and is not modulated by PGE2. IDO2 expression is constitutively, stably expressed in steady-state conditions and may contribute to the homeostatic tolerogenic capacity of DCs.

  7. Indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase (show WARS Proteins) may play critical roles in the immune pathogenesis of chronic kidney disease.

  8. Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 (show IDO1 Proteins) and IDO2) and discovery of selective IDO1 (show IDO1 Proteins) inhibitors.

  9. Data show that IDO2-specific T cells are cytotoxic effector cells that recognize and kill tumor cells.

  10. Tryptophan supplementation was able to completely restore hepatitis b virus replication in IFN-gamma (show IFNG Proteins)- but not IFN-alpha (show IFNA Proteins)-treated cells, which strongly argues that IDO (show IDO1 Proteins) is the primary mediator of IFN-gamma (show IFNG Proteins)-elicited antiviral response in human hepatocytes.

Mouse (Murine) Indoleamine 2,3-Dioxygenase 2 (IDO2) interaction partners

  1. Ido2 may be important for mouse embryo implantation and decidualization.

  2. The data showed that there is not significant effect of IDO1 (show IDO1 Proteins) or TDO2 (show TDO2 Proteins) on mortality in pneumococcal meningitis.

  3. IDO2 is critical for IDO1 (show IDO1 Proteins)-mediated T-cell regulation and exerts a non-redundant function in inflammation.

  4. Deletion of Ido1 (show IDO1 Proteins) and reduced mRNA expression for Ido2 neither affected the concentration of the downstream metabolites of tryptophan nor mRNA expression for downstream genes on the kynurenine pathway in inguinal lymph nodes.

  5. results provide important insights into IDO2 function by defining its pathogenic contributions to autoantibody-mediated autoimmunity.

  6. Immunohistochemical analysis in Ido1 (show IDO1 Proteins)(-/-) mouse epididymis showed that Ido2 protein was extensively upregulated due to the loss of Ido1 (show IDO1 Proteins) expression.

  7. IDO-1 (show IDO1 Proteins) and IDO-2 play biologically important, contradictory roles during intracellular protozoal infection - facilitating (Toxoplasma gondii) or suppressing (Leishmania major) microbial clearance in a pathogen-specific manner.

  8. Findings implicate novel IDO (show IDO1 Proteins) related enzyme IDO2 in cancer as a result of its preferential inhibition by the D racemer of 1-methyl-tryptophan, used widely in its racemic form (D,L-1MT) as an IDO (show IDO1 Proteins) inhibitor including as an anticancer agent

  9. A second tryptophan catabolic enzyme inducible by IFNg (show IFNG Proteins), implicated in transcriptional immune regulation (IFNg (show IFNG Proteins)-driven negative feedback), may limit the pro-inflammatory and anti-proliferative functions(Review)

  10. This article describes the evolutionary relationships between the INDO (show IDO1 Proteins) and INDOL1 genes. The INDOL1 protein has a distinct expression pattern compared to INDO (show IDO1 Proteins) and both have the ability to catabolise tryptophan.

IDO2 Protein Profile

Protein Summary

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007

Gene names and symbols associated with IDO2

  • indoleamine 2,3-dioxygenase 2 (IDO2)
  • indoleamine 2,3-dioxygenase 2 (Ido2)
  • AI265623 protein
  • C230043N17Rik protein
  • Ido-2 protein
  • Indol1 protein

Protein level used designations for IDO2

indoleamine 2,3-dioxygenase 2 , indoleamine 2,3-dioxygenase 2-like , IDO-2 , indoleamine 2,3-dioxygenase-like 1 protein , indoleamine 2,3-dioxygenase-like protein 1 , indoleamine-pyrrole 2,3 dioxygenase-like 1 , indoleamine-pyrrole 2,3-dioxygenase-like protein 1

GENE ID SPECIES
100402049 Callithrix jacchus
707424 Macaca mulatta
100085939 Ornithorhynchus anatinus
100435160 Pongo abelii
100480334 Ailuropoda melanoleuca
100580956 Nomascus leucogenys
169355 Homo sapiens
482846 Canis lupus familiaris
513810 Bos taurus
681319 Rattus norvegicus
209176 Mus musculus
100056686 Equus caballus
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