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Ligand for the T-cell-specific cell surface receptor ICOS. Additionally we are shipping Inducible T-Cell Co-Stimulator Ligand Antibodies (152) and Inducible T-Cell Co-Stimulator Ligand Proteins (24) and many more products for this protein.
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There was a clearly positive correlation between the presence of IL-17 (show IL17A ELISA Kits)-producing cells and ICOS (show ICOS ELISA Kits) expression in ICOSL KO mice; it also showed that Th17 was involved in the pathological tissue remodeling in liver fibrosis induced by schistosomiasis.
Selective ablation of ICOSL in CD11c (show ITGAX ELISA Kits)+ cells, but not in B cells, dramatically ameliorates kidney and lung inflammation in lupus-prone transgenic mice.
ICOS-ICOS (show ICOS ELISA Kits)-L interaction promoted cytokine production and survival in type 2 innate lymphoid cells through STAT5 (show STAT5A ELISA Kits) signaling in asthma.
restoring control of the T follicular helper-germinal center B-cell axis by blocking the ICOS (show ICOS ELISA Kits)-ICOSL pathway reduced the development of atherosclerosis and the formation of tertiary lymphoid organs.
ICOSL is a molecular linkage between T-B interactional dynamics and positive selection for high-affinity bone-marrow plasma cell formation; study reveals a pathway by which follicular T-helper cells control the quality of long-lived humoral immunity
the costimulatory ligand ICOS ligand (ICOSL) is selectively downregulated on the surface of B cells in an ADAM17 (show ADAM17 ELISA Kits)-specific manner, although it is not proteolitically processed by recombinant ADAM17 (show ADAM17 ELISA Kits) in vitro.
The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL and OX40L (show TNFSF4 ELISA Kits) in B7 deprived mice.
the B7h-ICOS (show ICOS ELISA Kits) interaction may modulate the spread of cancer metastases
Findings indicate the separable roles of delivery of antigens and ICOS-L by cognate B cells for follicular Th (Tfh) cell maturation and function.
Data indicate that the signals provided by ICOSL-expressing B cells to Teff cells and Tfh cells are necessary for the development of arthritis.
Loss-of-function mutations in NIK (show MAP3K14 ELISA Kits) cause impaired ICOSL expression.
ICOS-ICOS (show CTLA4 ELISA Kits)-L interaction promoted cytokine production and survival in type 2 innate lymphoid cells through STAT5 (show STAT5A ELISA Kits) signaling in asthma.
Our data show that mDCs from patients with AR display impaired expression of ICOSL, and this defect licenses mDCs to promote aberrant IL-13 (show IL13 ELISA Kits)- and IL-5 (show IL5 ELISA Kits)-producing Th2 cell responses.
These data suggest that rs2294020 SNP of FOXP3 (show FOXP3 ELISA Kits) gene and rs378299 SNP of ICOSLG gene are associated with alopecia areata and with a reduced expression of the FOXP3 (show FOXP3 ELISA Kits) and ICOSLG genes in alopecia patients.
a critical role is described for the rs7282490 ICOSLG region polymorphism associated with immune-mediated diseases in amplifying pattern-recognition receptor initiated inflammatory signaling and cytokine secretion
the B7h (show CD274 ELISA Kits)-ICOS (show CTLA4 ELISA Kits) interaction may modulate the spread of cancer metastases
Findings suggest that the single nucleotide polymorphism (snp) rs4819388 in B7-H2 3'-UTR (show UTS2R ELISA Kits), through disrupting the regulatory role of miR (show MLXIP ELISA Kits)-24 on B7-H2 expression, contributes to the occurrence of gastric cancer.
ICOS (show CTLA4 ELISA Kits)-ICOSL signaling plays a direct role in proliferation and differentiation of thyroid gland cells and may have important effects on the initiation, maintenance and exaggeration of autoimmune responses in local tissue.
Results highlight an important relationship between Treg and pDC (show PNKD ELISA Kits) in breast tumors, and show that ICOS/ICOS (show CTLA4 ELISA Kits)-L interaction is a central event in immunosuppression of tumor-associated memory CD4 (show CD4 ELISA Kits)(+) T cells.
ICOSL-expressing macrophages and mRNA levels of ICOSL were increased in the lesional skin of patients with early diffuse cutaneous systemic sclerosis.
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion\; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity).
, ICOS ligand
, inducible T-cell co-stimulator ligand
, B7 homolog 2
, B7-like protein Gl50
, B7-related protein 1
, B7 homologue 2
, transmembrane protein B7-H2 ICOS ligand
, icos ligand