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INHBP encodes a member of the immunoglobulin-like domain-containing superfamily. Additionally we are shipping Inhibin Binding Protein Kits (29) and Inhibin Binding Protein Proteins (9) and many more products for this protein.
Showing 10 out of 62 products:
Human Polyclonal INHBP Primary Antibody for EIA, IHC (p) - ABIN952871
Robakis, Bak, Lin, Bernard, Scheiffele: An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain protein. in The Journal of biological chemistry 2008
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Human Polyclonal INHBP Primary Antibody for IHC (p), WB - ABIN654689
Gui, Murphy: Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma. in The Journal of clinical endocrinology and metabolism 2001
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Human Polyclonal INHBP Primary Antibody for IHC, IHC (p) - ABIN4324071
Tanaka, Tatsumi, Okubo, Itoh, Kawamoto, Matsubara, Amino: Expression profile of active genes in the human pituitary gland. in Journal of molecular endocrinology 2002
Cow (Bovine) Polyclonal INHBP Primary Antibody for WB - ABIN2775563
Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. in Nucleic acids research 2005
Individuals with identical IGSF1 deletions can exhibit variable pituitary hormone deficiencies, of which overt TSH deficiency is the most consistent feature
IGSF1 Deficiency is associated with X-linked IGSF1 deficiency syndrome.
Adult male patients with IGSF1 deficiency exhibit mild deficits in attentional control on formal testing.
This case suggests that more attention should be paid to intrauterine growth and birth history when patients are suspected of having an IGSF1 mutation
There is insufficient evidence to conclude that the three observed VUCSs in IGSF1 are associated with CDGP, making it unlikely that IGSF1 mutations are a prevalent cause of CDGP.
Immunohistochemistry showed increased IGSF1 staining in the GH-producing tumor from the patient with the IGSF1 p.N604T variant compared with a GH-producing adenoma from a patient negative for any IGSF1 variants and with normal control pituitary tissue.
Data suggest male subjects with IGSF1 deficiency syndrome exhibit X-linked congenital/central hypothyroidism, delayed puberty, macro-orchidism, hypoprolactinemia, metabolic syndrome, and transient partial growth hormone deficiency. [CASE REPORTS]
Our findings provide additional genetic evidence that loss-of-function mutations in IGSF1 cause an X-linked form of C-CH and variable prolactin (show PRL Antibodies) deficiency.
Using exome and candidate gene sequencing, 8 distinct mutations and 2 deletions in IGSF1 were identified in males from 11 unrelated families with central hypothyroidism, testicular enlargement and variably low prolactin (show PRL Antibodies) concentrations.
IgSF1 is processed through sequential proteolysis by signal peptidase and signal peptide peptidase
Contrary to earlier predictions, neither the murine nor rat IGSF1-2 is secreted from heterologous or homologous cells. In addition, neither protein associates with the plasma membrane. Rather, IGSF1-2 appears to be retained in the endoplasmic reticulum.
Igsf1-deficient males exhibit normal serum TSH levels as well as normal numbers of TSH-expressing thyrotropes. However, pituitary expression of the TSH subunit genes and TSH protein content are reduced, as is expression of the receptor for thyrotropin-releasing hormone (TRH (show TRH Antibodies)
This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.
immunoglobulin superfamily member 1
, immunoglobulin-like domain-containing protein 1
, inhibin-binding protein
, pituitary gland-specific factor 2
, betaglycan and inhibin binding protein
, inhibin binding protein