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The protein encoded by ID1 is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. Additionally we are shipping ID1 Antibodies (79) and ID1 Kits (3) and many more products for this protein.
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Human ID1 Protein expressed in Wheat germ - ABIN1307349
Edhayan, Ohara, Stinson, Amin, Isozaki, Ha, Haines, Morgan, Campbell, Arbab, Friday, Fox, Ruth: Inflammatory properties of inhibitor of DNA binding 1 secreted by synovial fibroblasts in rheumatoid arthritis. in Arthritis research & therapy 2016
Gain and loss of id1 function in vivo demonstrated that Id1 promotes stem cell quiescence. The increased id1 expression observed in neural stem cells in response to injury appeared independent of inflammatory signals.
Id1 enables both Lewis lung carcinoma cells and the host microenvironment for an effective liver colonization.
adipose tissue-specific overexpression of Id1 causes age-associated and high-fat diet-induced obesity in mice. Id1 suppresses BAT (show BAAT Proteins) thermogenesis by binding to and suppressing PGC1alpha transcriptional activity. Lack of Id1 increases beige gene and Ucp1 (show UCP1 Proteins) expression in the WAT in response to cold exposure. Furthermore, brown-like differentiation is increased in Id1-deficient mouse embryonic fibroblasts.
If Gfi1 (show ZNF163 Proteins) levels fall below a threshold, Id1 expression increases and renders E2A (show TCF3 Proteins) unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage
Id1 may promote cell cycle progression of endothelial progenitor cells (EPCs), and that Wnt2 (show WNT2 Proteins) may be important in Id1 regulation of the cell cycle of EPCs.
Differential role of Id1 in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins)-driven leukemia based on cell of origin
Collectively, our results suggest that ENH1 plays an important role in the activation of myogenesis through the repression of Id2 activity.
Data indicate that upregulation of E2-2 (show TCF4 Proteins) protein markedly attenuated the inhibitor of DNA-binding 1 (ID1)-mediated increase in endothelial progenitor cells (EPCs) proliferation and migration.
our results strongly suggest that Usp1 (show USP1 Proteins) is involved in the regulation of centrosome duplication, at least in part via ID1, and Usp1 (show USP1 Proteins) may exert its oncogenic activity, partially through inducing centrosome abnormality.
demonstrated that Id1 and E2-2 (show TCF4 Proteins) are critical regulators of EPCs function in vitro. Id1 interacts with E2-2 (show TCF4 Proteins) and relieves the E2-2 (show TCF4 Proteins)-mediated repression of FGFR1 (show FGFR1 Proteins) and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions
Endothelial ID1 up-regulation in inflamed colonic mucosa is an adaptive response that modulates the severity of tissue injury.
Id1 enables lung cancer liver colonization by activating an epithelial mesenchymal transformation program in tumor cells and establishing the pre-metastatic niche.
High ID1 expression is associated with breast cancer.
ID1 expression impacts the sensitivity of colon cancer cells to 5-FU and may be considered as a potential predictive marker in colorectal carcinoma treatment.
Reducing ID1 gene expression reduces metastatic spread of salivary gland neoplasms.
High ID-1 expression is associated with colorectal carcinoma.
ID1 expression was positively related to drug resistance of EGFR (show EGFR Proteins)-TKI in non-small cell lung cancer.
MVD was determined by immunohistochemistry, and the expressions of mRNA and protein of inhibitor of differentiation-1 (ID1) and vascular endothelial growth factor (VEGF) were detected in gastric cancer.
ID1 down-regulation induced parallel changes in the IGF and AKT (show AKT1 Proteins) pathways. The crosstalk of these pathways may enhance malignant phenotypes in salivary gland cancer.
Results show that ID1, ID3 (show ID3 Proteins) and IGJ (show IGJ Proteins) genes are highly expressed in adult B-ALL and correlate with poor prognosis in Hispanic patients.
Our findings define an intricate E2F1-dependent mechanism by which Id1 increases thymidylate synthase and IGF2 expressions to promote cancer chemoresistance. The Id1-E2F1-IGF2 regulatory axis has important implications for cancer prognosis and treatment.
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
inhibitor of DNA binding 1
, DNA-binding protein inhibitor id-1
, inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
, DNA-binding protein inhibitor ID-1
, inhibitor of DNA binding 6
, Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation)
, Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)
, class B basic helix-loop-helix protein 24
, dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)
, inhibitor of differentiation 1
, helix-loop-helix protein