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The protein encoded by ID3 is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. Additionally we are shipping Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein Antibodies (143) and many more products for this protein.
Showing 7 out of 8 products:
Human ID3 Protein expressed in HEK-293 Cells - ABIN2723242
Das, Felty: PCB153-induced overexpression of ID3 contributes to the development of microvascular lesions. in PLoS ONE 2014
Immunohistochemical detection of inhibitor of DNA binding 3 mutational variants in mature aggressive B-cell lymphoma.
The results of the present study revealed that overexpression of Id3 may serve as a novel strategy for inhibiting cisplatinsensitive lung cancer.
Results show that ID1 (show ID1 Proteins), ID3 and IGJ (show IGJ Proteins) genes are highly expressed in adult B-ALL and correlate with poor prognosis in Hispanic patients.
Upon Id3 transfection, A549 cells displayed decreased migratory and invasive capabilities, however, co-transfection of miRId3 and Id3 into A549 cells reversed the Id3-induced inhibitions of migratory and invasive capabilities.
Inhibitor of differentiation 4 (ID4 (show ID4 Proteins)) acts as an inhibitor of ID-1 (show ID1 Proteins), -2 and -3 and promotes basic helix loop helix (bHLH) E47 (show TCF3 Proteins) DNA binding and transcriptional activity.
ID3 has a role in the acquisition of molecular stem cell-like signature in microvascular endothelial cells
our data provide evidence that ID3 may play a critical role in regulating vascular endothelial cell survival and development of microvascular lesions induced by persistent environmental pollutants such as PCB153.
ID3 plays a potential role in the underlying regulatory mechanisms of metabolic health in human obesity. [Review]
Epigenetic changes in ID3, in combination with experiences of maltreatment, may confer risk for depression in children.
Data indicate association of inhibitor of differentiation 3 (ID3) single nucleotide polymorphism rs11574 directly with coronary artery pathology.
Mechanistic analysis indicated that E47 (show TCF3 Proteins) activated expression of the transcription factor Spi-B (show SPIB Proteins) and the suppressor of cytokine signaling 3 (SOCS3 (show SOCS3 Proteins)), which both downregulated Foxp3 (show FOXP3 Proteins) expression. These findings demonstrate that the balance of Id3 and E47 (show TCF3 Proteins) controls the maintenance of Foxp3 (show FOXP3 Proteins) expression in Treg cells and, thus, contributes to Treg cell plasticity.
The present study provides additional support for roles for ID3 in the etiology of depression following early adversity.
Our work identifies a distinct premalignant state and multiple tumorigenic pathways caused by loss of function of Id2 and Id3
down-regulation of Id3 in B cells is essential for releasing E2A (show TCF3 Proteins) and E2-2 (show TCF4 Proteins), which in a redundant manner are required for antigen-induced B cell differentiation.
Results found that Id3 expression is high in follicular B lineage cells but declines in germinal center (GC) cells. However, during the GC reaction, Id3 levels decline to activate the expression of genes encoding signaling components that mediate B cell receptor- and or cytokine receptor (show LEPR Proteins)-mediated signaling to promote the differentiation of GC B (show NPR2 Proteins) cells.
These results identify Id3 as the BMP-2 (show BMP2 Proteins)-induced transcriptional regulator, promoting adult NSPC differentiation into astrocytes upon CNS injury
Inflammation-induced S100A8 (show S100A8 Proteins) promotes colorectal tumorigenesis by acting upstream to activate the Akt1 (show AKT1 Proteins)-Smad5 (show SMAD5 Proteins)-Id3 axis.
Data show that enforced expression of inhibitor of differentiation protein Id3 specifically increased the persistence of Cd244 (show CD244 Proteins) protein 2B4 (show CD244 Proteins)(+) virus-specific CD8 (show CD8A Proteins)(+) T cells.
ID2/3 are crucial regulators of the adaptive antioxidant-mitochondrial response that promotes beta cell survival during oxidative stress through a novel link to the NFE2L2 (show NFE2L2 Proteins)-small MAF (show MAF Proteins) pathway.
Enhanced IL-13 (show IL13 Proteins) production by T cells can play a causative role in the exocrinopathy observed in Id3 knockout mice.
Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.
expression of id3 in zebrafish embryo
Results provide evidence that the helix-loop-helix factor Id3 mediates the mitogenic effect of hyperlipemic sera and ox-LDL in VSMC via inhibition of p21cip1 (show CDKN1A Proteins) expression, subsequently increasing DNA synthesis and proliferation
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts.
DNA-binding protein inhibitor ID-3
, ID-like protein inhibitor HLH 1R21
, class B basic helix-loop-helix protein 25
, helix-loop-helix protein HEIR-1
, ID-like protein inhibitor HLH 462
, Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
, helix-loop-helix protein
, inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
, olfactory receptor 136-6
, olfactory receptor I-D3
, olfactory receptor MOR136-6
, DNA-binding protein inhibitor ID-3-B
, Inhibitor of DNA binding 3-B