Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by ID3 is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. Additionally we are shipping Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein Antibodies (143) and Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein Proteins (8) and many more products for this protein.
Our work identifies a distinct premalignant state and multiple tumorigenic pathways caused by loss of function of Id2 and Id3
down-regulation of Id3 in B cells is essential for releasing E2A (show TCF3 ELISA Kits) and E2-2 (show TCF4 ELISA Kits), which in a redundant manner are required for antigen-induced B cell differentiation.
Results found that Id3 expression is high in follicular B lineage cells but declines in germinal center (GC) cells. However, during the GC reaction, Id3 levels decline to activate the expression of genes encoding signaling components that mediate B cell receptor- and or cytokine receptor (show LEPR ELISA Kits)-mediated signaling to promote the differentiation of GC B (show NPR2 ELISA Kits) cells.
These results identify Id3 as the BMP-2 (show BMP2 ELISA Kits)-induced transcriptional regulator, promoting adult NSPC differentiation into astrocytes upon CNS injury
Inflammation-induced S100A8 (show S100A8 ELISA Kits) promotes colorectal tumorigenesis by acting upstream to activate the Akt1 (show AKT1 ELISA Kits)-Smad5 (show SMAD5 ELISA Kits)-Id3 axis.
Data show that enforced expression of inhibitor of differentiation protein Id3 specifically increased the persistence of Cd244 (show CD244 ELISA Kits) protein 2B4 (show CD244 ELISA Kits)(+) virus-specific CD8 (show CD8A ELISA Kits)(+) T cells.
ID2/3 are crucial regulators of the adaptive antioxidant-mitochondrial response that promotes beta cell survival during oxidative stress through a novel link to the NFE2L2 (show NFE2L2 ELISA Kits)-small MAF (show MAF ELISA Kits) pathway.
Enhanced IL-13 (show IL13 ELISA Kits) production by T cells can play a causative role in the exocrinopathy observed in Id3 knockout mice.
Tob1 and Tob2 (show TOB2 ELISA Kits) inhibit the cell cycle via degradation of Id3 mRNA, which is a set of directly targeted genes of BMP4 (show BMP4 ELISA Kits) signaling in embryonic stem cells.
A functional ID3 influences susceptibility to kidney disease and prevents glomerular injury.
Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.
expression of id3 in zebrafish embryo
Results provide evidence that the helix-loop-helix factor Id3 mediates the mitogenic effect of hyperlipemic sera and ox-LDL in VSMC via inhibition of p21cip1 (show CDKN1A ELISA Kits) expression, subsequently increasing DNA synthesis and proliferation
The results of the present study revealed that overexpression of Id3 may serve as a novel strategy for inhibiting cisplatinsensitive lung cancer.
Results show that ID1 (show ID1 ELISA Kits), ID3 and IGJ (show IGJ ELISA Kits) genes are highly expressed in adult B-ALL and correlate with poor prognosis in Hispanic patients.
Upon Id3 transfection, A549 cells displayed decreased migratory and invasive capabilities, however, co-transfection of miRId3 and Id3 into A549 cells reversed the Id3-induced inhibitions of migratory and invasive capabilities.
Inhibitor of differentiation 4 (ID4 (show ID4 ELISA Kits)) acts as an inhibitor of ID-1 (show ID1 ELISA Kits), -2 and -3 and promotes basic helix loop helix (bHLH) E47 (show TCF3 ELISA Kits) DNA binding and transcriptional activity.
ID3 has a role in the acquisition of molecular stem cell-like signature in microvascular endothelial cells
our data provide evidence that ID3 may play a critical role in regulating vascular endothelial cell survival and development of microvascular lesions induced by persistent environmental pollutants such as PCB153.
ID3 plays a potential role in the underlying regulatory mechanisms of metabolic health in human obesity. [Review]
Epigenetic changes in ID3, in combination with experiences of maltreatment, may confer risk for depression in children.
Data indicate association of inhibitor of differentiation 3 (ID3) single nucleotide polymorphism rs11574 directly with coronary artery pathology.
Importantly, the distinct ID3 expression patterns in acute leukemias (AL) indicate a specific deregulation of ID3 in the various types of AL and may support subtyping of AL.
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts.
DNA-binding protein inhibitor ID-3
, olfactory receptor 136-6
, olfactory receptor I-D3
, olfactory receptor MOR136-6
, helix-loop-helix protein
, inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
, ID-like protein inhibitor HLH 462
, Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
, ID-like protein inhibitor HLH 1R21
, class B basic helix-loop-helix protein 25
, helix-loop-helix protein HEIR-1