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ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. Additionally we are shipping ID4 Proteins (6) and ID4 Kits (3) and many more products for this protein.
Showing 10 out of 77 products:
Human Polyclonal ID4 Primary Antibody for ELISA, WB - ABIN1533741
Pagliuca, Bartoli, Saccone, Della Valle, Lania: Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. in Genomics 1995
Show all 2 references for ABIN1533741
Human Polyclonal ID4 Primary Antibody for IHC (p), WB - ABIN952816
Fontemaggi, DellOrso, Trisciuoglio, Shay, Melucci, Fazi, Terrenato, Mottolese, Muti, Domany, Del Bufalo, Strano, Blandino: The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis. in Nature structural & molecular biology 2009
Show all 2 references for ABIN952816
Chicken Polyclonal ID4 Primary Antibody for WB - ABIN2780374
Yu, Liu, Vandeusen, Becknell, Dai, Wu, Raval, Liu, Ding, Mao, Liu, Smith, Lee, Rassenti, Marcucci, Byrd, Caligiuri, Plass: Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. in Nature genetics 2005
Show all 2 references for ABIN2780374
Chicken Polyclonal ID4 Primary Antibody for WB - ABIN2779567
Russell, Akasaka, Majid, Sugimoto, Loraine Karran, Nagel, Harder, Claviez, Gesk, Moorman, Ross, Mazzullo, Strefford, Siebert, Dyer, Harrison: t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). in Blood 2007
Human Polyclonal ID4 Primary Antibody for WB - ABIN516801
Oatley, Kaucher, Racicot, Oatley: Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. in Biology of reproduction 2011
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.
Id4 regulates NKX3.1 (show NKX3-1 Antibodies), Sox9 (show SOX9 Antibodies) and PTEN (show PTEN Antibodies).
Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (show ESR1 Antibodies) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary
High expression levels of Id1 (show ID1 Antibodies)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 (show PRMT5 Antibodies) and were hypomethylated in PRMT5 (show PRMT5 Antibodies)-deficient cells, suggesting that PRMT5 (show PRMT5 Antibodies) plays a role in gene silencing during glial cell
ID4 promotes mammary gland development by suppressing p38MAPK (show MAPK14 Antibodies) activity.
Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.
Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.
ID4 has a role in adipocyte differentiation and the implications of this regulation for adipose tissue formation
ta indicate that Zik1 and Gja9 (show GJD2 Antibodies) demonstrated cancer-specific aberrant DNA methylation (show HELLS Antibodies), whereas, Cdkn2a/p16 (show CDKN2A Antibodies), Igfbp3 (show IGFBP3 Antibodies), Mgmt (show MGMT Antibodies), Id4, and Cxcr4 (show CXCR4 Antibodies) were methylated in both the AOM (show COL2A1 Antibodies) tumors and normal colon mucosa.
id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (show WNT2 Antibodies) signaling in the developing AVC endocardium
ID4 hypomethylation is present in tamoxifen-resistant breast cancer, and it may serve as a potential biomarker in distinguishing tamoxifen-resistant breast cancer.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 is specifically expressed by a subset of human basal-like breast cancer that possess a very poor prognosis and a transcriptional signature similar to a mammary stem cell.
The results showed that the detection of ID4 methylation positivity rates and levels could be a useful biomarker for MDS (show PAFAH1B1 Antibodies) diagnosis.
The chromosomal deletion 6p22.3 could result in the aberrant activation and mis (show AMH Antibodies)-expression of ID4 in the limb bud, thereby causing mesomelic dysplasia Savarirayan type.
Myelodysplastic syndrome patients with ID4 methylation had shorter survival time than those without ID4 methylation .
Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1 (show ID1 Antibodies), -2 and -3 and promotes basic helix loop helix (bHLH) E47 (show TCF3 Antibodies) DNA binding and transcriptional activity.
Increased hypermethylation of ID4 is associated with Triple negative breast cancer.
Inhibitor of DNA Binding 4 (ID4) is highly expressed in human melanoma tissues and may function to restrict normal differentiation of melanoma cells
TGF-beta (show TGFB1 Antibodies) suppression followed by Id4 expression results in extensive melanin synthesis and robust histiocyte recruitment following tumorigenesis
Data indicate a PRC2 dependent mechanism in ID4 promoter silencing in prostate cancer through recruitment of EZH2 (show EZH2 Antibodies) and a corresponding increase in H3K27Me3.
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.
DNA-binding protein inhibitor ID-4
, inhibitor of DNA binding 4 a
, class B basic helix-loop-helix protein 27