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ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. Additionally we are shipping ID4 Antibodies (79) and ID4 Kits (3) and many more products for this protein.
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results indicate that Id4 marks spermatogonial stem cells in the mouse testis.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.
Id4 regulates NKX3.1, Sox9 and PTEN.
Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (show ESR1 Proteins) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary
High expression levels of Id1 (show ID1 Proteins)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 (show PRMT5 Proteins) and were hypomethylated in PRMT5 (show PRMT5 Proteins)-deficient cells, suggesting that PRMT5 (show PRMT5 Proteins) plays a role in gene silencing during glial cell
ID4 promotes mammary gland development by suppressing p38MAPK (show MAPK14 Proteins) activity.
Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.
Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.
ID4 has a role in adipocyte differentiation and the implications of this regulation for adipose tissue formation
id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (show WNT2 Proteins) signaling in the developing AVC endocardium
Hypermethylation of ID4 promotes the proliferation of Burkitt's lymphoma cells; ID4 may function as a tumor suppressor and can be targeted with demethylating compounds such as CdR (show RUNX1T1 Proteins) for the treatment of Burkitt's lymphoma
the unmethylation of ID4 is an epigenetic predictor of BRCAness phenotype in breast tumors.
ID4 hypomethylation is present in tamoxifen-resistant breast cancer, and it may serve as a potential biomarker in distinguishing tamoxifen-resistant breast cancer.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 is specifically expressed by a subset of human basal-like breast cancer that possess a very poor prognosis and a transcriptional signature similar to a mammary stem cell.
The results showed that the detection of ID4 methylation positivity rates and levels could be a useful biomarker for MDS (show PAFAH1B1 Proteins) diagnosis.
The chromosomal deletion 6p22.3 could result in the aberrant activation and mis (show AMH Proteins)-expression of ID4 in the limb bud, thereby causing mesomelic dysplasia Savarirayan type.
Myelodysplastic syndrome patients with ID4 methylation had shorter survival time than those without ID4 methylation .
Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1 (show ID1 Proteins), -2 and -3 and promotes basic helix loop helix (bHLH) E47 (show TCF3 Proteins) DNA binding and transcriptional activity.
Increased hypermethylation of ID4 is associated with Triple negative breast cancer.
Inhibitor of DNA Binding 4 (ID4) is highly expressed in human melanoma tissues and may function to restrict normal differentiation of melanoma cells
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.
DNA-binding protein inhibitor ID-4
, inhibitor of DNA binding 4 a
, class B basic helix-loop-helix protein 27