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ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. Additionally we are shipping ID4 Proteins (6) and ID4 Kits (4) and many more products for this protein.
Showing 10 out of 79 products:
Dog (Canine) Polyclonal ID4 Primary Antibody for WB - ABIN2780374
Yu, Liu, Vandeusen, Becknell, Dai, Wu, Raval, Liu, Ding, Mao, Liu, Smith, Lee, Rassenti, Marcucci, Byrd, Caligiuri, Plass: Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. in Nature genetics 2005
Show all 2 Pubmed References
Human Polyclonal ID4 Primary Antibody for IHC (p), IHC - ABIN314651
Vincent, Li, Lee, Liu, Etter, Diaz-Perez, Taylor, Gkountela, Lindgren, Clark: Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells. in PLoS ONE 2011
Human Polyclonal ID4 Primary Antibody for WB - ABIN516801
Oatley, Kaucher, Racicot, Oatley: Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. in Biology of reproduction 2011
ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states
results indicate that Id4 marks spermatogonial stem cells in the mouse testis.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.
Id4 regulates NKX3.1 (show NKX3-1 Antibodies), Sox9 (show SOX9 Antibodies) and PTEN (show PTEN Antibodies).
Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (show ESR1 Antibodies) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary
High expression levels of Id1 (show ID1 Antibodies)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 (show PRMT5 Antibodies) and were hypomethylated in PRMT5 (show PRMT5 Antibodies)-deficient cells, suggesting that PRMT5 (show PRMT5 Antibodies) plays a role in gene silencing during glial cell
ID4 promotes mammary gland development by suppressing p38MAPK (show MAPK14 Antibodies) activity.
Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.
Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.
id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (show WNT2 Antibodies) signaling in the developing AVC endocardium
The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC (show FAM126A Antibodies)) patients, and overexpression of Id4 promoted HCC (show FAM126A Antibodies) cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.
ID4 selectively regulates AR activity through direct interaction with FKBP52 (show FKBP4 Antibodies).
High ID4 expression is associated with basal breast cancer.
A cell-autonomous positive-signaling circuit is associated with the PDGFB (show PDGFB Antibodies)-NO-ID4-regulatory axis in glioblastoma cells.
ID4 expression induces AR expression in PC3 (show PCSK1 Antibodies) cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.
CEACAM1 (show CEACAM1 Antibodies) is able to maintain the active transcription of ID4 by an epigenetic mechanism involving HDAC4 (show HDAC4 Antibodies) and CaMK2D (show CAMK2D Antibodies), and the same kinase enables lumen formation by CEACAM1 (show CEACAM1 Antibodies)
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (show NR4A2 Antibodies))early growth response (EGR)2 (show EGR2 Antibodies) and NR4A2EGR3. Therefore, RUNX1 (show RUNX1 Antibodies), NR4A2 (show NR4A2 Antibodies), EGR2 (show EGR2 Antibodies), EGR3 (show EGR3 Antibodies) and ID4 may be key genes associated with the pathogenesis of DS.
changes in gene amplification in the mitochondrial genome and in the ID4 gene promoter methylation region in patients with chronic aplastic anemia (CAA) suffering from Kidney (Shen) yin deficiency or Kidney yang deficiency, were analyzed.
Hypermethylation of ID4 promotes the proliferation of Burkitt's lymphoma cells; ID4 may function as a tumor suppressor and can be targeted with demethylating compounds such as CdR (show RUNX1T1 Antibodies) for the treatment of Burkitt's lymphoma
the unmethylation of ID4 is an epigenetic predictor of BRCAness phenotype in breast tumors.
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.
DNA-binding protein inhibitor ID-4
, inhibitor of DNA binding 4 a
, class B basic helix-loop-helix protein 27