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ING1 encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. Additionally we are shipping Inhibitor of Growth Family, Member 1 Antibodies (137) and Inhibitor of Growth Family, Member 1 Proteins (8) and many more products for this protein.
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ING1a acts as a novel link in the activation of the Rb pathway that can impose senescence in the absence of activating p53 (show TP53 ELISA Kits)-mediated DNA damage signaling, and should prove useful in defining the molecular events contributing to Rb-induced senescence.
These data indicate that stromal ING1 expression can predict the survival of patients with luminal breast cancer
Overexpression of let-7b in gastric cancer can inhibit invasion and migration of gastric cancer cells through directly targeting the tumor metastasis-associated gene ING1.
Results show that ING1 expression is under-regulated in pancreatic duct adenocarcinoma (PDAC) and is a direct target of miR (show MLXIP ELISA Kits)-371-5p involved in miR (show MLXIP ELISA Kits)-371-5p inducing promotion of PDAC cells proliferation.
ING1b finely regulates the hypoxic response by triggering HIF1alpha (show HIF1A ELISA Kits) proteasomal degradation.
ING1b sumoylation regulates the binding of ING1b to the ISG15 (show ISG15 ELISA Kits) and DGCR8 (show DGCR8 ELISA Kits) promoters, consequently regulating ISG15 (show ISG15 ELISA Kits) and DGCR8 (show DGCR8 ELISA Kits) transcription.
Our results identify a novel functional relationship between cytoplasmic p33ING1b and oral squamous cell carcinoma patient survival
ING1 translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 (show TP53 ELISA Kits) status.
ING1 acts at early stages of the DNA damage response activating a variety of repair mechanisms.
Src (show SRC ELISA Kits) may play a major role in regulating ING1 levels during tumorigenesis in those cancers in which high levels of Src (show SRC ELISA Kits) expression or activity are present.
ING1b is an important regulator of osteoblast differentiation and suppresses PPAR-beta (show PPARD ELISA Kits)/delta.
Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1.
Study reveals a novel connection between ING1 and a regulator of microRNA biogenesis and identifies new links between tumor suppressor proteins and the microRNA machinery.
Identification of the p33(ING1)-regulated genes that include cyclin B1 (show CCNB1 ELISA Kits) and proto-oncogene (show RAB1A ELISA Kits) DEK (show DEK ELISA Kits) by using cDNA microarray in a mouse mammary epithelial cell line NMuMG
Characterization of nuclear localization signal in mouse ING1 homolog protein.
p33ING1 expression induces features of cellular senescence through two silencing domains and interaction with Ras
the suggested role of ing1 as a candidate tumor suppressor gene involved in control of DNA damage response.
p37 (show UBXN2B ELISA Kits)(Ing1) can negatively regulate cell growth and apoptosis in a p53 (show TP53 ELISA Kits)-independent manner.
important role for the Ing1 locus in protection against oncogenic stress in vivo, both as a mediator of p53 (show TP53 ELISA Kits) activation and as a regulator of chromatin remodeling processes.
Analysis of marker gene expression in p37 (show UBXN2B ELISA Kits)(Ing1b)/p53 (show TP53 ELISA Kits) null tumors indicates that the double-null mice develop both nongerminal center and germinal center B-cell-like DLBL.
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
inhibitor of growth family, member 1
, inhibitor of growth protein 1
, growth inhibitor ING1
, growth inhibitory protein ING1
, tumor suppressor ING1
, inhibitor of growth
, tumor suppressor