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Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) ELISA Kits

The protein encoded by IKBKAP is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. Additionally we are shipping Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Antibodies (80) and Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse IKBKAP IKBKAP 230233 Q7TT37
Anti-Human IKBKAP IKBKAP 8518 O95163
Anti-Rat IKBKAP IKBKAP 140934 Q8VHU4
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More ELISA Kits for Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Interaction Partners

Arabidopsis thaliana Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) interaction partners

  1. show that the Elongator (elo1, elo2, and elo3) complex was purified from plant cell cultures as a six-component complex.

  2. Elongator is important for plants to respond to ABA and drought exposure and that ABO1/ELO2 may play a vital role in ABA signal transduction pathways.[ABO1]

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) interaction partners

  1. ELP1 has a neuron autonomous role in sympathetic and sensory target tissue innervation

  2. Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model for Familial dysautonomia.

  3. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3 (show PAX3 ELISA Kits)+ progenitors and peripheral neurons.

  4. our study not only reveals a novel function of IKAP in meiosis, but also suggests that IKAP contributes to this process partly by exerting its effect on transcription and tRNA modification

  5. IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia.

  6. IKAP is essential for expression of specific genes involved in cardiac morphogenesis (show XIRP1 ELISA Kits), and cardiac failure is the likely cause of abnormal vascular development and embryonic lethality; deletion of exon 20 abolishes gene function

  7. mutations in the human I-kappaB kinase-associated protein (IKBKAP) gene are responsible for familial dysautonomia (FD).no animal model of FD currently exists, cloning of the mouse Ikbkap gene is an important step toward creating a mouse model for FD

  8. description of a humanized IKBKAP transgenic mouse that models a tissue-specific human splicing defect

  9. IKAP is crucial for both vascular and neural development during embryogenesis and that protein function is conserved between mouse and human.

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) interaction partners

  1. IKAP might be a vesicular like protein that might be involved in neuronal transport in hESC derived PNS neurons

  2. The formation of the Elp1 dimer contributes to its stability in vitro and in vivo and is required for the assembly of human Elongator complexes.

  3. IKBKAP mRNA levels decreased during a familial dysautonomia crisis and returned to baseline after recovery. The cause-and-effect relationship is unclear.

  4. Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model for Familial dysautonomia.

  5. Digoxin-mediated repression of SRSF3 (show SRSF3 ELISA Kits) expression plays a role in the digoxin-mediated inclusion of exon 20 in the IKBKAP transcript generated from the familial dysautonomia mutant allele.

  6. Combined treatment with epigallocatechin gallate and genistein synergistically upregulates wild-type IKBKAP-encoded RNA and protein levels in familial dysautonomia-derived cells.

  7. IKAP plays pleiotropic roles in both the peripheral and central nervous systems

  8. IKAP/hELP1 deficiency has an effect on gene expression in differentiating neuroblastoma (show ARHGEF16 ELISA Kits) cells, and possibly on familial dysautonomia

  9. IKK complex-associated protein deficiency upregulates the microtubule destabilizing protein SCG10 (show STMN2 ELISA Kits) and, in parallel, disorganizes the cytoskeleton

  10. Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells

Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) Antigen Profile

Antigen Summary

The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.

Gene names and symbols associated with IKBKAP

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (ikbkap) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (LOC100229335) antibody
  • elongator complex protein 1 (ABO1) antibody
  • inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein (Ikbkap) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (Ikbkap) antibody
  • 3110040G09Rik antibody
  • 6030413P05 antibody
  • ABA-OVERLY SENSITIVE 1 antibody
  • C78473 antibody
  • DKFZp469N1415 antibody
  • DYS antibody
  • ELO2 antibody
  • ELONGATA 2 antibody
  • ELP1 antibody
  • FD antibody
  • IKAP antibody
  • IKBKAP antibody
  • IKI3 antibody
  • MSH12.15 antibody
  • MSH12_15 antibody
  • TOT1 antibody

Protein level used designations for IKBKAP

elongator complex protein 1 , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein , IKK complex-associated protein , IKK-complex-associated protein IKAP , ikappaB kinase complex-associated protein , inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein , elongator acetyltransferase complex subunit 1 , p150 , ELP1 , IKAP , putative elongator complex protein 1

GENE ID SPECIES
427375 Gallus gallus
473014 Pan troglodytes
612455 Canis lupus familiaris
100170442 Xenopus (Silurana) tropicalis
100171912 Pongo abelii
100229335 Taeniopygia guttata
100560669 Anolis carolinensis
100585002 Nomascus leucogenys
831213 Arabidopsis thaliana
230233 Mus musculus
8518 Homo sapiens
140934 Rattus norvegicus
100009360 Oryctolagus cuniculus
735009 Xenopus laevis
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