anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) Antibodies

The protein encoded by IKBKAP is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. Additionally we are shipping Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IKBKAP 230233 Q7TT37
IKBKAP 8518 O95163
IKBKAP 140934 Q8VHU4
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Top anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Antibodies at antibodies-online.com

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB IKBKAP monoclonal antibody (M03), clone 6G9 Western Blot analysis of IKBKAP expression in HeLa on formalin-fixed paraffin-embedded human colon (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Cow Rabbit Un-conjugated IHC (p), ELISA, WB Human Lung, Nerve (formalin-fixed, paraffin-embedded) stained with IKBKAP antibody ABIN214271 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to IKBKAP on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] IKBKAP monoclonal antibody (M03), clone 6G9 Western Blot analysis of IKBKAP expression in HeLa . 100 μg Log in to see 11 to 12 Days
$430.00
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB Human Prostate (formalin-fixed, paraffin-embedded) stained with IKBKAP antibody ABIN214497 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Testis (formalin-fixed, paraffin-embedded) stained with IKBKAP antibody ABIN214497 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
$451.00
Details
Dog Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$537.17
Details
Human Rabbit Un-conjugated WB Western Blot: IKBKAP Antibody [ABIN153156] - Analysis of IKBKAP in Interleukin-1-stimulated 293 cells using this antibody at 1:500 dilution. 0.1 mg Log in to see 7 to 9 Days
$381.94
Details
Human Rabbit Un-conjugated ICC, IF, WB Immunocytochemistry/Immunofluorescence: IKBKAP Antibody [NBP2-16936] - HeLa cells were fixed in iced-cold MeOH for 5 min. Green: IKBKAP protein stained by IKBKAP antibody, Internal diluted at 1:500. Blue: Hoechst 33343 staining. Western Blot: IKBKAP Antibody [NBP2-16936] - Sample (30 ug of whole cell lysate) A: HeLa B: HepG2 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details

IKBKAP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Antibodies

  1. Human Polyclonal IKBKAP Primary Antibody for ICC, ELISA - ABIN1002511 : Krappmann, Hatada, Tegethoff, Li, Klippel, Giese, Baeuerle, Scheidereit: The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component. in The Journal of biological chemistry 2000 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal IKBKAP Primary Antibody for IHC (p), ELISA - ABIN563666 : Lefler, Cohen, Kantor, Cheishvili, Even, Birger, Turetsky, Gil, Even-Ram, Aizenman, Bashir, Maayan, Razin, Reubinoff, Weil: Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation. in PLoS ONE 2015 (PubMed)

More Antibodies against Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein Interaction Partners

Arabidopsis thaliana Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) interaction partners

  1. show that the Elongator (elo1, elo2, and elo3) complex was purified from plant cell cultures as a six-component complex.

  2. Elongator is important for plants to respond to ABA and drought exposure and that ABO1/ELO2 may play a vital role in ABA signal transduction pathways.[ABO1]

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) interaction partners

  1. Results show that although Ikbkap is not required for normal development of retinal ganglion cells, its loss causes a slow, progressive retinal ganglion cells degeneration most severely in the temporal retina, which is later followed by indirect photoreceptor loss and complete retinal disorganization.

  2. Our results show that tissue-specific expression of RBM24 (show RBM24 Antibodies) can explain the neuron-specific aberrant splicing of IKBKAP exon 20 in familial dysautonomia, and that ectopic expression of RBM24 (show RBM24 Antibodies) in neuronal tissue could be a novel therapeutic target of the disease.

  3. ELP1 has a neuron autonomous role in sympathetic and sensory target tissue innervation

  4. Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model for Familial dysautonomia.

  5. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3 (show PAX3 Antibodies)+ progenitors and peripheral neurons.

  6. our study not only reveals a novel function of IKAP in meiosis, but also suggests that IKAP contributes to this process partly by exerting its effect on transcription and tRNA modification

  7. IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia.

  8. IKAP is essential for expression of specific genes involved in cardiac morphogenesis (show XIRP1 Antibodies), and cardiac failure is the likely cause of abnormal vascular development and embryonic lethality; deletion of exon 20 abolishes gene function

  9. mutations in the human I-kappaB kinase-associated protein (IKBKAP) gene are responsible for familial dysautonomia (FD).no animal model of FD currently exists, cloning of the mouse Ikbkap gene is an important step toward creating a mouse model for FD

  10. description of a humanized IKBKAP transgenic mouse that models a tissue-specific human splicing defect

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) interaction partners

  1. IKAP might be a vesicular like protein that might be involved in neuronal transport in hESC derived PNS neurons

  2. The formation of the Elp1 dimer contributes to its stability in vitro and in vivo and is required for the assembly of human Elongator complexes.

  3. IKBKAP mRNA levels decreased during a familial dysautonomia crisis and returned to baseline after recovery. The cause-and-effect relationship is unclear.

  4. Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model for Familial dysautonomia.

  5. Digoxin-mediated repression of SRSF3 (show SRSF3 Antibodies) expression plays a role in the digoxin-mediated inclusion of exon 20 in the IKBKAP transcript generated from the familial dysautonomia mutant allele.

  6. Combined treatment with epigallocatechin gallate and genistein synergistically upregulates wild-type IKBKAP-encoded RNA and protein levels in familial dysautonomia-derived cells.

  7. IKAP plays pleiotropic roles in both the peripheral and central nervous systems

  8. IKAP/hELP1 deficiency has an effect on gene expression in differentiating neuroblastoma (show ARHGEF16 Antibodies) cells, and possibly on familial dysautonomia

  9. IKK complex-associated protein deficiency upregulates the microtubule destabilizing protein SCG10 (show STMN2 Antibodies) and, in parallel, disorganizes the cytoskeleton

  10. Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells

Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase Complex-Associated Protein (IKBKAP) Antigen Profile

Protein Summary

The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.

Gene names and symbols associated with IKBKAP

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (ikbkap) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (LOC100229335) antibody
  • elongator complex protein 1 (ABO1) antibody
  • inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein (Ikbkap) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (Ikbkap) antibody
  • 3110040G09Rik antibody
  • 6030413P05 antibody
  • ABA-OVERLY SENSITIVE 1 antibody
  • C78473 antibody
  • DKFZp469N1415 antibody
  • DYS antibody
  • ELO2 antibody
  • ELONGATA 2 antibody
  • ELP1 antibody
  • FD antibody
  • IKAP antibody
  • IKBKAP antibody
  • IKI3 antibody
  • MSH12.15 antibody
  • MSH12_15 antibody
  • TOT1 antibody

Protein level used designations for IKBKAP

elongator complex protein 1 , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein , IKK complex-associated protein , IKK-complex-associated protein IKAP , ikappaB kinase complex-associated protein , inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein , elongator acetyltransferase complex subunit 1 , p150 , ELP1 , IKAP , putative elongator complex protein 1

GENE ID SPECIES
427375 Gallus gallus
473014 Pan troglodytes
612455 Canis lupus familiaris
100170442 Xenopus (Silurana) tropicalis
100171912 Pongo abelii
100229335 Taeniopygia guttata
100560669 Anolis carolinensis
100585002 Nomascus leucogenys
831213 Arabidopsis thaliana
230233 Mus musculus
8518 Homo sapiens
140934 Rattus norvegicus
100009360 Oryctolagus cuniculus
735009 Xenopus laevis
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