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The protein encoded by ITPA hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. Additionally we are shipping Inosine Triphosphatase Proteins (24) and Inosine Triphosphatase Kits (12) and many more products for this protein.
Showing 10 out of 80 products:
Mouse (Murine) Polyclonal ITPA Primary Antibody for IHC, WB - ABIN3021765
Lin, McLennan, Ying, Wang, Gu, Jin, Wu, Liu, Yuan, Tang, Xie, Mao: Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene. in The Journal of biological chemistry 2001
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Human Polyclonal ITPA Primary Antibody for FACS, IF - ABIN651135
Fellay, Thompson, Ge, Gumbs, Urban, Shianna, Little, Qiu, Bertelsen, Watson, Warner, Muir, Brass, Albrecht, Sulkowski, McHutchison, Goldstein: ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. in Nature 2010
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Human Monoclonal ITPA Primary Antibody for ELISA - ABIN517268
Vroemen, Munnix, Bakker, Bierau, Huts, Leers: A novel multiparameter flow cytometric assay for inosine triphosphatase expression analysis in leukocytes. in Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012
Inosine triphosphatase (IPTA) rs1127354 variants but not rs7270101 were found in Chinese patients infected with chronic hepatitis C. IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the virological response to pegylated interferon (show IFNA Antibodies) plus ribavirin combination therapy in Chinese chronic hepatitis C virus-infected patients.
This study concluded that HIV-infection seems to be interfering with the nucleotide metabolism in leukocytes, including CD4 (show CD4 Antibodies) lymphocytes, by decreasing ITPase expression, independently of ITPA genotype.
A high prevalence of the ITPA polymorphisms associated with ribavirin-induced hemolytic anemia was found in Mexican Native Amerindians.
ITPA gene is associated with protection of anemia in patients with chronic hepatitis during antiviral therapy.
We concluded that ITPase activity plays an important function and that ATP concentration changes due to therapy are related to the Hb decreasing mechanism in the early period of therapy with HCV treatment
The aim of the study was to investigate frequencies of TPMT (show TPMT Antibodies) and ITPA polymorphisms in Lithuanian inflammatory bowel disease patients and analyze their association with azathioprine-related adverse events.
ITPA polymorphism was associated with RBV-induced anemia and thrombocytopenia in Egyptian patients with hepatitis C virus genotype 4 infection.
Hyperbilirubinemia develops at early time points after simeprevir administration in most cases and is dependent on the ITPA genotype.
Genetic variants in inosine triphosphatase (ITPA) gene have been linked to the haemolytic anaemia induced by peg (show PAEP Antibodies)-interferon (show IFNA Antibodies) and ribavirin treatment.
The association of IL28B (show IL28B Antibodies) and APOH (show APOH Antibodies) single nucleotide polymorphisms (SNPs) with sustained virological response and of ITPA SNPs with anemia related phenotypes.
In the mouse genome, we found one processed Itpa gene-like sequence and two processed Itpa pseudogenes as well as the Itpa gene itself with introns.
The role of ITPase in mice is to exclude ITP from the ATP pool, and the main target substrate of this enzyme is rITP
This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants.
inosine triphosphate pyrophosphatase
, inosine triphosphatase
, inosine triphosphatase-A
, inosine triphosphate pyrophosphohydrolase
, non-canonical purine NTP pyrophosphatase
, non-standard purine NTP pyrophosphatase
, nucleoside-triphosphate diphosphatase
, putative oncogene protein HLC14-06-P
, nucleoside-triphosphate pyrophosphatase
, nucleoside triphosphate pyrophosphatase
, inosine triphosphatase A
, Non-canonical purine NTP pyrophosphatase
, Non-standard purine NTP pyrophosphatase
, Nucleoside-triphosphate diphosphatase
, Nucleoside-triphosphate pyrophosphatase
, Inosine triphosphatase
, hypothetical protein
, cancer-related nucleoside-triphosphatase
, human cancer-related NTPase
, nucleoside triphosphate phosphohydrolase
, nucleoside-triphosphatase C1orf57