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IP6K2 encodes a protein that belongs to the inositol phosphokinase (IPK) family. Additionally we are shipping IP6K2 Antibodies (40) and IP6K2 Proteins (9) and many more products for this protein.
IP6K2 is a positive regulator of Hh signaling.
An alpha-helical pair and a rare, two-turn 310 helix, that together form a substrate-binding pocket of IP6K2.
FGF2 (show FGF2 ELISA Kits)-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 (show RUNX2 ELISA Kits) and osteoblast gene expression.
Genetic polymorphisms in IP6K2 gene is associated with autoimmune disease.
Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.
Gene disruption of IP6K2 in colorectal cancer cells selectively impairs p53 (show TP53 ELISA Kits)-mediated apoptosis, instead favoring cell-cycle arrest. IP6K2 acts by binding directly to p53 (show TP53 ELISA Kits) and decreasing expression of proarrest gene targets
IHPK2 over expression enhances sensitivity of ovarian carcinoma cells to radiation, IFN-beta, caspase 8 and DR4
IHPK2-TRAF2 (show TRAF2 ELISA Kits) binding leads to attenuation of TAK1 (show MAP3K7 ELISA Kits)- and NF-kappaB (show NFKB1 ELISA Kits)-mediated signaling and is partially responsible for the apoptotic activity of IHPK2.
A role for PI3 kinase (show PIK3CA ELISA Kits) pathway in the airway smooth muscle cellular response to insulin (show INS ELISA Kits).
IP6K2 is a major mediator of cancer cell migration and tumor metastasis, acting by enhancing cell-matrix adhesion and decreasing cell-cell adhesion.
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.
inositol hexaphosphate kinase 2
, Inositol hexakisphosphate kinase 2
, inositol hexakisphosphate kinase 2
, inositol hexakisphosphate kinase 2-like
, inositol hexaphosphate kinase 2b
, inositol hexaphosphate kinase 2 a
, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
, insp6 kinase 2
, pi uptake stimulator
, InsP6 kinase 2
, P(i)-uptake stimulator
, insP6 kinase 2
, p(i)-uptake stimulator