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Inositol Monophosphatase Domain Containing 1 Proteins (IMPAD1)

IMPAD1 encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. Additionally we are shipping Inositol Monophosphatase Domain Containing 1 Antibodies (31) and Inositol Monophosphatase Domain Containing 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IMPAD1 54928 Q9NX62
Rat IMPAD1 IMPAD1 312952 D4AD37
IMPAD1 242291 Q80V26
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Top Inositol Monophosphatase Domain Containing 1 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 0.025 mg Log in to see 2 to 3 Days
$433.13
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

IMPAD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

Top referenced Inositol Monophosphatase Domain Containing 1 Proteins

  1. Human IMPAD1 Protein expressed in Escherichia coli (E. coli) - ABIN1098736 : Kalujnaia, McVee, Kasciukovic, Stewart, Cramb: A role for inositol monophosphatase 1 (IMPA1) in salinity adaptation in the euryhaline eel (Anguilla anguilla). in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 (PubMed)
    Show all 2 references for ABIN1098736

More Proteins for Inositol Monophosphatase Domain Containing 1 (IMPAD1) Interaction Partners

Human Inositol Monophosphatase Domain Containing 1 (IMPAD1) interaction partners

  1. In human B cells, SPPL2a (show SPPL2A Proteins) is indispensable for turnover of CD74 (show CD74 Proteins) N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a (show SPPL2A Proteins) transcript and protein.

  2. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a (show SPPL2A Proteins)).

  3. concluded that IMPAD1 should be screened for patients with Catel-Manzke and additional features

  4. Data show that endogenous SPPL2a (show SPPL2A Proteins) - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.

  5. Affected individuals carried homozygous missense mutations in IMPAD1, the gene coding for gPAPP, a Golgi-resident nucleotide phosphatase that hydrolyzes phosphoadenosine phosphate (PAP (show REG3A Proteins)), the byproduct of sulfotransferase reactions, to AMP (show APRT Proteins).

  6. SPP, SPPL2a (show SPPL2A Proteins), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  7. ADAM10 (show ADAM10 Proteins) and SPPL2a (show SPPL2A Proteins) were identified as two proteases implicated in FasL (show FASL Proteins) processing and release of the FasL (show FASL Proteins) intracellular domain, which has been shown to be important for retrograde FasL (show FASL Proteins) signaling

  8. SPPL2a (show SPPL2A Proteins) and SPPL2b (show SPPL2B Proteins) mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (show ITM2B Proteins) N-terminal fragment.

Mouse (Murine) Inositol Monophosphatase Domain Containing 1 (IMPAD1) interaction partners

  1. Golgi plays an important role in glycosaminoglycan sulfation and define a function for gPAPP in the formation of skeletal elements derived through endochondral ossification[3'-phosphoadenosine 5'-phosphate phosphatase]

  2. identify JAWS as a key regulator of chondrogenesis and synovial joint positioning required for the restriction of joint formation to discrete stereotyped locations in the embryonic skeleton

Inositol Monophosphatase Domain Containing 1 (IMPAD1) Protein Profile

Protein Summary

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.

Gene names and symbols associated with IMPAD1

  • inositol monophosphatase domain containing 1 (IMPAD1)
  • inositol monophosphatase domain containing 1 (Impad1)
  • inositol monophosphatase domain containing 1 (impad1)
  • signal peptide peptidase like 2A (SPPL2A)
  • 1110001C20Rik protein
  • AA408880 protein
  • AI451589 protein
  • AL022796 protein
  • B230207P20 protein
  • gPAPP protein
  • IMP-3 protein
  • IMP 3 protein
  • IMP3 protein
  • impa3 protein
  • Jaws protein
  • PSL2 protein
  • RGD1306455 protein

Protein level used designations for IMPAD1

inositol monophosphatase domain containing 1 , myo-inositol monophosphatase A3 , inositol monophosphatase 3 , inositol monophosphatase 3-like , Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase , IMPase 3 , golgi-resident PAP phosphatase , inositol monophosphatase domain-containing protein 1 , inositol-1(or 4)-monophosphatase 3 , Ac2-190 , Golgi-resident PAP phosphatase , IMP 3 , Inositol monophosphatase domain-containing protein 1 , Inositol-1(or 4)-monophosphatase 3 , Myo-inositol monophosphatase A3 , IMP-3 , SPP-like 2A , intramembrane cleaving protease , intramembrane protease 3 , presenilin-like protein 2 , signal peptide peptidase-like 2A

GENE ID SPECIES
421132 Gallus gallus
464188 Pan troglodytes
696893 Macaca mulatta
100343037 Oryctolagus cuniculus
100453710 Pongo abelii
100602566 Nomascus leucogenys
54928 Homo sapiens
312952 Rattus norvegicus
477890 Canis lupus familiaris
100156925 Sus scrofa
532797 Bos taurus
242291 Mus musculus
100395037 Callithrix jacchus
414458 Xenopus laevis
84888 Homo sapiens
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