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The protein encoded by INPPL1 is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. Additionally we are shipping Inositol Polyphosphate Phosphatase-Like 1 Kits (3) and Inositol Polyphosphate Phosphatase-Like 1 Proteins (3) and many more products for this protein.
Showing 10 out of 72 products:
these findings suggest that SHIP2 is an important regulator of hepatic lipogenesis and lipoprotein secretion in insulin (show INS Antibodies) resistance state.
investigated the molecular link between SHIP2 expression and metabolic dyslipidemia using overexpression or suppression of SHIP2 gene in HepG2 cells
Findings indicate that SHIP2 is a regulator of lymphatic function in humans and that inherited mutations in the INPPL1 gene may act in concert with HGF (show HGF Antibodies), and likely MAP3K7 (show MAP3K7 Antibodies), mutations to exacerbate lymphatic phenotypes.
SHIP2 inhibition was accompanied by an increased Akt (show AKT1 Antibodies) and FOXO-1 (show FOXO1 Antibodies) phosphorylation, whereas overexpression of the wild-type SHIP2 gene had the opposite effects
In conclusion, SHIP2 plays a key role in breast cancer stem cells of ER-negative breast cancers
Kaplan-Meier method and Cox (show COX8A Antibodies) multifactor analysis suggested that high SHIP2 protein level and positive distant metastasis were critically associated with the unfavorable survival of coloretal cancer patients.
results indicated genotype and allele frequency of SHIP2(+1893CC/AA) locus in Type 2 diabetes mellitus (T2DM) Han Chinese patients was significantly different from healthy controls; G allele (+2945A/G) seemed to increase susceptibility to hypertension for T2DM patients
The crystal structures of human SHIP2 in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer.
Association with SHIP2 and aging might depend on its effect on the insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) pathway.
SHIP2 localization in intact cells is dependent on phosphorylation mechanisms on both Ser (show SIGLEC1 Antibodies)/Thr (show TRH Antibodies) and Tyr (show TYR Antibodies) residues.
These findings suggest that palmitate contributes to SHIP2 overexpression in skeletal muscle via the mechanisms involving the activation of ceramide-JNK (show MAPK8 Antibodies) and NF-kappaB (show NFKB1 Antibodies) pathways.
results suggest that SHIP2 contributes to the regulation of food intake mainly via the attenuation of insulin (show INS Antibodies) signalling in the hypothalamus of mice
The catalytically-inactive Ship2 mutant protein in a context of reduced PtdIns(4,5)P2 3-kinase activity.
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
These results suggest that SHIP2 is a potent negative regulator of insulin (show INS Antibodies)/IGF-I (show IGF1 Antibodies) actions in the brain, and excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin (show INS Antibodies) resistance with type 2 diabetes.
The SHIP2 is a negative regulator of insulin (show INS Antibodies) signaling, our findings suggest the importance of the phosphoinositide metabolism at endocytic clathrin-coated pits in the regulation of insulin (show INS Antibodies) signal output.
Association with the insulin (show INS Antibodies) resistance of diabetic db/db (show LEPR Antibodies) mice.
The role of SHIP2 in controlling phosphatidylinositol 3,4,5-trisphosphate levels in platelets.
SH2-containing inositol phosphatase 2 predominantly regulates Akt2 (show AKT2 Antibodies), and not Akt1 (show AKT1 Antibodies), phosphorylation at the plasma membrane in response to insulin (show INS Antibodies) in adipocytes
SHIP2 plays an important role in the negative regulation of insulin (show INS Antibodies) signaling for protein synthesis and the impact of SHIP2 is altered, dependent on the acute or chronic exposure of excess concentrations of amino acids in culture.
we suggest that SHIP2 might play a role in the regulation of skeletal muscle development in pigs
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
SH2-domain-containing inositol 5-phosphatase 2b
, inositol polyphosphate phosphatase-like 1
, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2-like
, 51C protein
, SH2 domain-containing inositol 5'-phosphatase 2
, SH2 domain-containing inositol-5'-phosphatase 2
, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
, protein 51C
, SH2 domain-containing inositol phosphatase 2
, ablSH3-binding protein
, inositol polyphosphate phosphatase-like protein 1
, SH2-containing inositol phosphatase 2