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anti-Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) Antibodies

The protein encoded by INPPL1 is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. Additionally we are shipping Inositol Polyphosphate Phosphatase-Like 1 Kits (3) and Inositol Polyphosphate Phosphatase-Like 1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
INPPL1 3636 O15357
INPPL1 16332 Q6P549
INPPL1 65038 Q9WVR3
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Top anti-Inositol Polyphosphate Phosphatase-Like 1 Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Anti-INPPL1 antibody, Western blotting Lane 1: Rat Heart Tissue Lysate Lane 2: U87 Cell Lysate Lane 3:  Cell Lysate Lane 4: MCF-7 Cell Lysate Anti-INPPL1 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of SHIP2 expression in A549 (A), NS-1 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-INPPL1 Polyclonal Antibody, Unconjugated (ABIN722200) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, WB 20 μg Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IHC (p), WB   20 μg Log in to see 8 to 10 Days
$669.17
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

INPPL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against Inositol Polyphosphate Phosphatase-Like 1 Interaction Partners

Zebrafish Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

Human Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

  1. these findings suggest that SHIP2 is an important regulator of hepatic lipogenesis and lipoprotein secretion in insulin (show INS Antibodies) resistance state.

  2. investigated the molecular link between SHIP2 expression and metabolic dyslipidemia using overexpression or suppression of SHIP2 gene in HepG2 cells

  3. Findings indicate that SHIP2 is a regulator of lymphatic function in humans and that inherited mutations in the INPPL1 gene may act in concert with HGF (show HGF Antibodies), and likely MAP3K7 (show MAP3K7 Antibodies), mutations to exacerbate lymphatic phenotypes.

  4. SHIP2 inhibition was accompanied by an increased Akt (show AKT1 Antibodies) and FOXO-1 (show FOXO1 Antibodies) phosphorylation, whereas overexpression of the wild-type SHIP2 gene had the opposite effects

  5. In conclusion, SHIP2 plays a key role in breast cancer stem cells of ER-negative breast cancers

  6. Kaplan-Meier method and Cox (show COX8A Antibodies) multifactor analysis suggested that high SHIP2 protein level and positive distant metastasis were critically associated with the unfavorable survival of coloretal cancer patients.

  7. results indicated genotype and allele frequency of SHIP2(+1893CC/AA) locus in Type 2 diabetes mellitus (T2DM) Han Chinese patients was significantly different from healthy controls; G allele (+2945A/G) seemed to increase susceptibility to hypertension for T2DM patients

  8. The crystal structures of human SHIP2 in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer.

  9. Association with SHIP2 and aging might depend on its effect on the insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) pathway.

  10. SHIP2 localization in intact cells is dependent on phosphorylation mechanisms on both Ser (show SIGLEC1 Antibodies)/Thr (show TRH Antibodies) and Tyr (show TYR Antibodies) residues.

Mouse (Murine) Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

  1. These findings suggest that palmitate contributes to SHIP2 overexpression in skeletal muscle via the mechanisms involving the activation of ceramide-JNK (show MAPK8 Antibodies) and NF-kappaB (show NFKB1 Antibodies) pathways.

  2. results suggest that SHIP2 contributes to the regulation of food intake mainly via the attenuation of insulin (show INS Antibodies) signalling in the hypothalamus of mice

  3. The catalytically-inactive Ship2 mutant protein in a context of reduced PtdIns(4,5)P2 3-kinase activity.

  4. Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).

  5. These results suggest that SHIP2 is a potent negative regulator of insulin (show INS Antibodies)/IGF-I (show IGF1 Antibodies) actions in the brain, and excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin (show INS Antibodies) resistance with type 2 diabetes.

  6. The SHIP2 is a negative regulator of insulin (show INS Antibodies) signaling, our findings suggest the importance of the phosphoinositide metabolism at endocytic clathrin-coated pits in the regulation of insulin (show INS Antibodies) signal output.

  7. Association with the insulin (show INS Antibodies) resistance of diabetic db/db (show LEPR Antibodies) mice.

  8. The role of SHIP2 in controlling phosphatidylinositol 3,4,5-trisphosphate levels in platelets.

  9. SH2-containing inositol phosphatase 2 predominantly regulates Akt2 (show AKT2 Antibodies), and not Akt1 (show AKT1 Antibodies), phosphorylation at the plasma membrane in response to insulin (show INS Antibodies) in adipocytes

  10. SHIP2 plays an important role in the negative regulation of insulin (show INS Antibodies) signaling for protein synthesis and the impact of SHIP2 is altered, dependent on the acute or chronic exposure of excess concentrations of amino acids in culture.

Pig (Porcine) Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) interaction partners

  1. we suggest that SHIP2 might play a role in the regulation of skeletal muscle development in pigs

Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) Antigen Profile

Protein Summary

The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.

Gene names and symbols associated with INPPL1

  • inositol polyphosphate phosphatase-like 1b (inppl1b) antibody
  • inositol polyphosphate phosphatase-like 1 (INPPL1) antibody
  • inositol polyphosphate phosphatase-like 1 (LOC100339369) antibody
  • phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1-like (LOC100180571) antibody
  • inositol polyphosphate phosphatase-like 1 (Inppl1) antibody
  • 51C antibody
  • INPPL1 antibody
  • OPSMD antibody
  • Ship2 antibody
  • si:bz46j2.7 antibody
  • si:rp71-46j2.7 antibody

Protein level used designations for INPPL1

SH2-domain-containing inositol 5-phosphatase 2b , inositol polyphosphate phosphatase-like 1 , ship2b , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2-like , 51C protein , INPPL-1 , SH2 domain-containing inositol 5'-phosphatase 2 , SH2 domain-containing inositol-5'-phosphatase 2 , SHIP-2 , phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 , protein 51C , SH2 domain-containing inositol phosphatase 2 , ablSH3-binding protein , inositol polyphosphate phosphatase-like protein 1 , SH2-containing inositol phosphatase 2

GENE ID SPECIES
368433 Danio rerio
428692 Gallus gallus
451403 Pan troglodytes
100339369 Oryctolagus cuniculus
100482460 Ailuropoda melanoleuca
100180571 Ciona intestinalis
100596562 Nomascus leucogenys
3636 Homo sapiens
16332 Mus musculus
65038 Rattus norvegicus
485209 Canis lupus familiaris
783833 Bos taurus
100462718 Sus scrofa
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