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INPP4A encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Additionally we are shipping INPP4A Kits (8) and INPP4A Proteins (5) and many more products for this protein.
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This study showed that spontaneous Inpp4a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
These results suggest a novel mechanism of action of resveratrol in attenuating asthma phenotype by downregulating PI3K-Akt (show AKT1 Antibodies) pathway via upregulating INPP4A.
INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death
Purkinje cell loss in the Inpp4a(wbl) mutant is due to glutamate (show GRIN1 Antibodies) excitotoxicity initiated by the climbing fiber, and that Eaat4 (show SLC1A6 Antibodies) may exert a protective effect.
Study provides the first evidence that inositol polyphosphate 4-phosphatase-1 controls the activation of Akt (show AKT1 Antibodies) and thereby cell proliferation, survival and tumorigenesis.
Data adds a new etiology to the spectrum of hindbrain malformations in human, and when presented with myoclonic epilepsy may lead to the clinical suspicion of INPP4A defect.
The +110832A/G (Thr (show TRH Antibodies)/Ala) variant of INPP4A was significantly associated with asthma in an Indian population.
This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described.
inositol polyphosphate 4-phosphatase type I
, inositol polyphosphate-4-phosphatase, type 1
, inositol polyphosphate-4-phosphatase, type I, 107kD
, type I inositol 3,4-bisphosphate 4-phosphatase
, type I inositol-3,4-bisphosphate 4-phosphatase