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INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. Additionally we are shipping INPP4B Antibodies (24) and many more products for this protein.
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Study provides evidence that INPP4B loss can promote follicular-like thyroid cancer progression and metastasis in the context of PTEN haploinsufficiency through the isoform-specific regulation of AKT (show AKT1 Proteins) signaling at the endosomes.
Results provide evidence that INPP4B is a bona fide tumor suppressor whose function is particularly important in situations of PTEN deficiency. Biochemical data demonstrates that INPP4B directly dephosphorylates PtdIns(3,4,5)P3.
ERalpha (show ESR1 Proteins) plays a protective role in bladder cancer initiation and growth at least partly via modulating the INPP4B/Akt (show AKT1 Proteins) pathway.
mice carrying the longer-latency Inpp4b allele(474R/548P)) exhibited significantly longer cortical motor evoked potential latencies indicating that INPP4B regulates nerve conduction velocity
Hyperactivation of the PI3K/AKT (show AKT1 Proteins) pathway caused by the decrease in INPP4B in granulosa cells promotes an ovarian environment defective in folliculogenesis and conducive to teratoma (show DND1 Proteins) formation.
In vivo mice deficient in Inpp4b displayed increased osteoclast differentiation rate and potential resulting in decreased bone mass and osteoporosis
This study provides first insight for a physiological role of PI-4-phosphatase II in the proerythroblast by controlling Epo (show EPO Proteins) responsiveness through a negative regulation of the PI3K/Akt (show AKT1 Proteins) pathway
Data show that activation of serum- and glucocorticoid-regulated kinase 3 (SGK3 (show SGK3 Proteins)) plays an important role in inositol polyphosphate 4-phosphatase type II (INPP4B)-mediated melanoma cell proliferation.
Studies in human tissues suggest that reductions in INPP4B and PTEN co-occur in human thyroid and endometrial cancers. INPP4B may therefore be an important regulator of cancer progression, especially in the context of PTEN insufficiency.
Given that INPP4B loss has been found in 40% of ovarian cancer patients, this study provides the rationale for establishing INPP4B as a biomarker of PARP inhibitor response.
Epigenetic inactivation of INPP4B is one of the key mechanisms in activating PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling cascade and playing a role in the tumorigenesis of nasopharyngeal carcinoma.
There were no significant associations of PIK3CA (show PIK3CA Proteins) copy number, pAKt (show AKT1 Proteins), or INPP4B with trastuzumab efficacy.
INPP4B is a novel suppressor of oncogenic PKC (show PRRT2 Proteins) signaling, further emphasizing the role of INPP4B in maintaining normal physiology of the prostate epithelium and suppressing metastatic potential of prostate tumors.
INPP4B overexpression is associated with therapy resistance in acute myeloid leukemia (show BCL11A Proteins)
). We find that RAD50 (show RAD50 Proteins) and INPP4B expression levels have a synergistic influence on breast cancer survival, possibly through their effects on treatment response.
Seventy-nine percent of the ovarian cancers demonstrated loss of INPP4B, most frequently in serous and endometrioid cancer subtypes.
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.
inositol polyphosphate 4-phosphatase type II beta isoform
, type II inositol 3,4-bisphosphate 4-phosphatase
, type II inositol-3,4-bisphosphate 4-phosphatase
, inositol polyphosphate 4-phosphatase type II
, inositol polyphosphate-4-phosphatase type II 105kD
, inositol polyphosphate-4-phosphatase, type II, 105kD
, inositol polyphosphate 4-phosphatase II; 4-phosphatase II