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anti-Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) Antibodies

The protein encoded by INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. Additionally we are shipping INPP5E Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
INPP5E 64436 Q9JII1
INPP5E 114089  
INPP5E 56623 Q9NRR6
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Top anti-INPP5E Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of INPP5E expression in HEK293T (A), SP2/0 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$375.83
Details
Human Rabbit Un-conjugated WB   50 μL Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated WB Western Blot analysis of INPP5E expression in transfected 293T cell line by INPP5E MaxPab polyclonal antibody.Lane 1: INPP5E transfected lysate(70.2 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated WB Western Blot analysis of INPP5E expression in transfected 293T cell line by INPP5E MaxPab polyclonal antibody.Lane 1: INPP5E transfected lysate(70.84 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB   50 μL Log in to see 9 to 11 Days
$313.50
Details
Human Rabbit Un-conjugated IF, IHC, WB   100 μL Log in to see 11 to 16 Days
$675.71
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 11 to 16 Days
$553.14
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$742.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB   50 μL Log in to see 3 to 4 Days
$510.36
Details

INPP5E Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)


Rat (Rattus)


Human
,

More Antibodies against INPP5E Interaction Partners

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. the affinity to PDE6delta and the release by Arl2 (show ARL2 Antibodies)/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.

  2. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  3. Inpp5e, through functional interactions with Rab20 (show RAB20 Antibodies) on the phagosome, activates Rab5 (show RAB5A Antibodies), which, in turn, increases PtdIns3P and delays phagosome acidification.

  4. Inpp5e and SHIP1 (show INPP5D Antibodies) exhibit specificity in regulating FcgammaR- versus CR3 (show ITGAM Antibodies)-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup.

  5. Inpp5e mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in the mouse.

Human Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. MKS1 (show MKS1 Antibodies) functions in the transition zone at the base of the cilium to regulate ciliary INPP5E content.

  2. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  3. These findings establish the first direct link between AURKA (show AURKA Antibodies) and phosphoinositide signaling and suggest that the function of INPP5E in cilia is at least partly mediated by its interactions with AURKA (show AURKA Antibodies)

  4. Proteomic analysis identified INPP5E, whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D (show PDE6D Antibodies). Mutant PDE6D (show PDE6D Antibodies) shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues.

  5. Identification of 12 different INPP5E mutations in patients with Joubert syndrome with an overall 2.7% mutation frequency.

  6. findings indicate that ARL13B (show ARL13B Antibodies), INPP5E, PDE6D (show PDE6D Antibodies), and CEP164 (show CEP164 Antibodies) form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS (show MKS1 Antibodies) proteins

  7. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in humans.

  8. Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.

INPP5E Antigen Profile

Protein Summary

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome\; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.

Gene names and symbols associated with INPP5E

  • inositol polyphosphate-5-phosphatase E (Inpp5e) antibody
  • inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E) antibody
  • 72kDa antibody
  • 1200002L24Rik antibody
  • CORS1 antibody
  • CPD4 antibody
  • JBTS1 antibody
  • mKIAA0123 antibody
  • MORMS antibody
  • PMPCA antibody
  • PPI5PIV antibody

Protein level used designations for INPP5E

72 kDa inositol polyphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase, 72 kDa , phosphatidylinositol 4,5-bisphosphate 5-phosphatase , phosphatidylinositol polyphosphate 5-phosphatase type IV , phosphatidylinositol-4,5-bisphosphate 5-phosphatase , 5-phosphatase that induces arborization , inositol polyphosphate 5-phosphatase , pharbin , phosphatidylinositol (4,5) bisphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase E , peptidase (mitochondrial processing) alpha

GENE ID SPECIES
64436 Mus musculus
114089 Rattus norvegicus
56623 Homo sapiens
748603 Pan troglodytes
Selected quality suppliers for anti-INPP5E (INPP5E) Antibodies
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