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Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) ELISA Kits

The protein encoded by INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. Additionally we are shipping INPP5E Antibodies (17) and INPP5E Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse INPP5E INPP5E 64436 Q9JII1
Anti-Rat INPP5E INPP5E 114089  
Anti-Human INPP5E INPP5E 56623 Q9NRR6
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More ELISA Kits for INPP5E Interaction Partners

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. the affinity to PDE6delta and the release by Arl2 (show ARL2 ELISA Kits)/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.

  2. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  3. Inpp5e, through functional interactions with Rab20 on the phagosome, activates Rab5 (show RAB5A ELISA Kits), which, in turn, increases PtdIns3P and delays phagosome acidification.

  4. Inpp5e and SHIP1 (show INPP5D ELISA Kits) exhibit specificity in regulating FcgammaR- versus CR3 (show ITGAM ELISA Kits)-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup.

  5. Inpp5e mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in the mouse.

Human Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. PIPKIgamma and INPP5E (show PMPCA ELISA Kits) localize to the centrosome and coordinate the initiation of ciliogenesis.

  2. These findings establish the first direct link between AURKA (show AURKA ELISA Kits) and phosphoinositide signaling and suggest that the function of INPP5E (show PMPCA ELISA Kits) in cilia is at least partly mediated by its interactions with AURKA (show AURKA ELISA Kits)

  3. Proteomic analysis identified INPP5E (show PMPCA ELISA Kits), whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D (show PDE6D ELISA Kits). Mutant PDE6D (show PDE6D ELISA Kits) shows reduced binding to INPP5E (show PMPCA ELISA Kits), which fails to localize to primary cilia in patient fibroblasts and tissues.

  4. Identification of 12 different INPP5E (show PMPCA ELISA Kits) mutations in patients with Joubert syndrome with an overall 2.7% mutation frequency.

  5. findings indicate that ARL13B (show ARL13B ELISA Kits), INPP5E (show PMPCA ELISA Kits), PDE6D (show PDE6D ELISA Kits), and CEP164 (show CEP164 ELISA Kits) form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS (show MKS1 ELISA Kits) proteins

  6. INPP5E (show PMPCA ELISA Kits) mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in humans.

  7. Mutations in INPP5E (show PMPCA ELISA Kits), encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.

INPP5E Antigen Profile

Antigen Summary

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome\; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.

Gene names and symbols associated with INPP5E

  • inositol polyphosphate-5-phosphatase E (Inpp5e) antibody
  • inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E) antibody
  • 72kDa antibody
  • 1200002L24Rik antibody
  • CORS1 antibody
  • CPD4 antibody
  • JBTS1 antibody
  • mKIAA0123 antibody
  • MORMS antibody
  • PMPCA antibody
  • PPI5PIV antibody

Protein level used designations for INPP5E

72 kDa inositol polyphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase, 72 kDa , phosphatidylinositol 4,5-bisphosphate 5-phosphatase , phosphatidylinositol polyphosphate 5-phosphatase type IV , phosphatidylinositol-4,5-bisphosphate 5-phosphatase , 5-phosphatase that induces arborization , inositol polyphosphate 5-phosphatase , pharbin , phosphatidylinositol (4,5) bisphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase E , peptidase (mitochondrial processing) alpha

64436 Mus musculus
114089 Rattus norvegicus
56623 Homo sapiens
748603 Pan troglodytes
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