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INPP5K encodes a protein with 5-phosphatase activity toward polyphosphate inositol. Additionally we are shipping INPP5K Proteins (8) and many more products for this protein.
Showing 10 out of 26 products:
the physiological role of Pak1 (show PAK1 Antibodies)-SKIP binding is in the regulation of insulin (show INS Antibodies) signaling in skeletal muscle
SKIP controls the IGF-II-PI 3 (show PI3 Antibodies)-kinase-Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) auto-regulation loop during myogenesis.
Specific suppression of insulin (show INS Antibodies) signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1 (show PAK1 Antibodies).
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
Results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin (show AVP Antibodies)/aquaporin-2 (show AQP2 Antibodies) signalling pathway and water transport in kidney collecting ducts.
Silencer of death domains (SODD (show BAG4 Antibodies)) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt (show AKT1 Antibodies) signaling to the actin cytoskeleton.
Data shoe that the N-terminal domain of SifA is sufficient to interact with the pleckstrin (show PLEK Antibodies) homology domain of SKIP, forming a 1:1 complex with a micromolar dissociation constant.
These results imply that SKIP regulates insulin (show INS Antibodies) signaling in skeletal muscle.
results suggest that SKIP (skeletal muscle and kidney-enriched inositol phosphatase) plays a negative regulatory role in Akt (show AKT1 Antibodies)/ GSK-3beta (show GSK3b Antibodies)/GS (glycogen synthase) pathway leading to glycogen (show GYS1 Antibodies) synthesis in myocytes
The authors report that HBV core protein interacts with a cellular SKIP (skeletal muscle and kidney enriched inositol phosphatase) protein, an endoplasmic reticulum-located phosphoinositide 5-phosphatase (show INPP5B Antibodies), both in vivo and in vitro.
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.
, inositol polyphosphate 5-phosphatase K
, putative phosphoinositide 5-phosphatase type II
, putative phosphoinositide 5-phosphatase type II; C62
, skeletal muscle and kidney enriched inositol phosphatase
, PI-5-phosphatase related
, putative PI-5-phosphatase
, skeletal muscle and kidney enriched inositol polyphosphate phosphatase
, skeletal muscle and kidney-enriched inositol phosphatase