Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) ELISA Kits

The protein encoded by INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. Additionally we are shipping INPP5E Antibodies (20) and INPP5E Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse INPP5E INPP5E 64436 Q9JII1
Anti-Rat INPP5E INPP5E 114089  
Anti-Human INPP5E INPP5E 56623 Q9NRR6
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More ELISA Kits for INPP5E Interaction Partners

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT (show AKT1 ELISA Kits)/GSK3beta (show GSK3b ELISA Kits) signaling axis at cilia in SHH (show SHH ELISA Kits)-dependent medulloblastoma that is regulated by INPP5E to maintain tumor cell cilia, promote SHH (show SHH ELISA Kits) signaling and thereby medulloblastoma progression.

  2. we identify Inpp5e as an essential inhibitor of the PI3K/Akt (show AKT1 ELISA Kits)/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD (show PRKD1 ELISA Kits)) suppression

  3. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit.

  4. INPP5E is an essential point of convergence between Hedgehog (show SHH ELISA Kits) and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog (show SHH ELISA Kits)-dependent embryonic development.

  5. the affinity to PDE6delta and the release by Arl2 (show ARL2 ELISA Kits)/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.

  6. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  7. Inpp5e, through functional interactions with Rab20 on the phagosome, activates Rab5 (show RAB5A ELISA Kits), which, in turn, increases PtdIns3P and delays phagosome acidification.

  8. Inpp5e and SHIP1 (show INPP5D ELISA Kits) exhibit specificity in regulating FcgammaR- versus CR3 (show ITGAM ELISA Kits)-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup.

  9. Inpp5e mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in the mouse.

Human Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) interaction partners

  1. we identify Inpp5e (show PMPCA ELISA Kits) as an essential inhibitor of the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e (show PMPCA ELISA Kits)-dependent mTORC1 regulation in Polycystic kidney disease (PKD (show PRKD1 ELISA Kits)) suppression

  2. ARL13B (show ARL13B ELISA Kits) regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E (show PMPCA ELISA Kits).

  3. In neuronal cells, INPP5E (show PMPCA ELISA Kits) knockdown strongly inhibited autophagy by impairing the autophagosome-lysosome fusion step.

  4. INPP5E (show PMPCA ELISA Kits) localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit.

  5. INPP5E (show PMPCA ELISA Kits) is an essential point of convergence between Hedgehog (show SHH ELISA Kits) and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog (show SHH ELISA Kits)-dependent embryonic development.

  6. MKS1 (show MKS1 ELISA Kits) functions in the transition zone at the base of the cilium to regulate ciliary INPP5E (show PMPCA ELISA Kits) content.

  7. PIPKIgamma and INPP5E (show PMPCA ELISA Kits) localize to the centrosome and coordinate the initiation of ciliogenesis.

  8. These findings establish the first direct link between AURKA (show AURKA ELISA Kits) and phosphoinositide signaling and suggest that the function of INPP5E (show PMPCA ELISA Kits) in cilia is at least partly mediated by its interactions with AURKA (show AURKA ELISA Kits)

  9. Proteomic analysis identified INPP5E (show PMPCA ELISA Kits), whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D (show PDE6D ELISA Kits). Mutant PDE6D (show PDE6D ELISA Kits) shows reduced binding to INPP5E (show PMPCA ELISA Kits), which fails to localize to primary cilia in patient fibroblasts and tissues.

  10. Identification of 12 different INPP5E (show PMPCA ELISA Kits) mutations in patients with Joubert syndrome with an overall 2.7% mutation frequency.

INPP5E Antigen Profile

Antigen Summary

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome\; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.

Gene names and symbols associated with INPP5E

  • inositol polyphosphate-5-phosphatase E (Inpp5e) antibody
  • inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E) antibody
  • 72kDa antibody
  • 1200002L24Rik antibody
  • CORS1 antibody
  • CPD4 antibody
  • JBTS1 antibody
  • mKIAA0123 antibody
  • MORMS antibody
  • PMPCA antibody
  • PPI5PIV antibody

Protein level used designations for INPP5E

72 kDa inositol polyphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase, 72 kDa , phosphatidylinositol 4,5-bisphosphate 5-phosphatase , phosphatidylinositol polyphosphate 5-phosphatase type IV , phosphatidylinositol-4,5-bisphosphate 5-phosphatase , 5-phosphatase that induces arborization , inositol polyphosphate 5-phosphatase , pharbin , phosphatidylinositol (4,5) bisphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase E , peptidase (mitochondrial processing) alpha

GENE ID SPECIES
64436 Mus musculus
114089 Rattus norvegicus
56623 Homo sapiens
748603 Pan troglodytes
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