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ITPKC encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. Additionally we are shipping ITPKC Antibodies (60) and ITPKC Kits (1) and many more products for this protein.
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The expression of ITPKC in various ciliated tissues suggest a role for the enzyme either in the development or in the function of these specialized cellular structures.
These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6 (show GPRIN2 Proteins), at least in mouse embryonic fibroblasts.[Itpka (show ITPKA Proteins), Itpkb (show ITPKB Proteins), Itpkc]
this study shows that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 (show NLRP3 Proteins) expression and production of IL-1beta (show IL1B Proteins) and IL-18 (show IL18 Proteins).
ITPKC polymorphisms are associated with Kawasaki disease.
SNP rs7251246 in ITPKC is associated with the severity of Kawasaki disease
Our results identify a novel polymorphism for renal function and highlight the importance of ITPKC as a key molecule to regulate calcium signaling.
a combinatorial association between ITPKC (rs28493229) and CASP3 (show CASP3 Proteins) (rs113420705) was found in coronary artery lesion formation (P = 0.0227, OR: 3.06)in Taiwanese population
functional studies demonstrated that PPP3CC positively influences the protein level of ITPKC, likely by inhibiting phosphorylation of ITPKC and consequently preventing ITPKC from ubiquitin-mediated protein degradation
Functional single-nucleotide polymorphisms in ITPKC and CASP3 (show CASP3 Proteins) are associated with susceptibility to Kawasaki's disease (KD).
the functional polymorphism rs28493229 in ITPKC significantly contributes to the risk of Kawasaki disease.
The C allele of the ITPKC gene rs2290692 is linked to a significantly higher risk for KD in the Han Chinese population studied.
ITPKC susceptibility in Kawasaki syndrome is related to its synergy with environmental triggers, such as thimerosal, which alter calcium homeostasis and promote oxidative stress.
This gene encodes a member of the inositol 1,4,5-trisphosphate
inositol-trisphosphate 3-kinase C
, inositol 1,4,5-trisphosphate 3-kinase C
, inositol-trisphosphate 3-kinase C-like
, IP3 3-kinase C
, IP3K C
, insP 3-kinase C
, InsP 3 kinase C