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anti-Insulin Induced Gene 1 (INSIG1) Antibodies

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
INSIG1 3638 O15503
INSIG1 231070 Q8BGI3
INSIG1 64194 Q08755
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Top anti-Insulin Induced Gene 1 Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-INSIG1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-INSIG1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-INSIG1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1... Immunohistochemistry with Liver tissue at an antibody concentration of... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$315.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of INSIG1 Antibody (N-term) (ABIN652887) in Hela... INSIG1 Antibody (N-term) (ABIN652887) flow cytometry analysis of Hela ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-INSIG1 antibody IHC staining of human liver. Immunohistochemistry... 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB INSIG1 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details

INSIG1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,

Mouse (Murine) , , , ,

Rat (Rattus) , , ,

Top referenced anti-Insulin Induced Gene 1 Antibodies

  1. Chicken Polyclonal INSIG1 Primary Antibody for WB - ABIN2778638 : Li, Gruidl, Eschrich, McCarthy, Wang, Alexandrow, Yeatman: Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis. in International journal of cancer. Journal international du cancer 2008 (PubMed)

  2. Human Polyclonal INSIG1 Primary Antibody for WB - ABIN2778635 : Roth, Looser, Kaufmann, Blättler, Rencurel, Huang, Moore, Meyer: Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. in Molecular pharmacology 2008 (PubMed)

More Antibodies against Insulin Induced Gene 1 Interaction Partners

Human Insulin Induced Gene 1 (INSIG1) interaction partners

  1. identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.

  2. Data show the essential role of PPARgamma (show PPARG Antibodies) and PPARgamma (show PPARG Antibodies) coactivator 1alpha (PGC-1alpha (show PPARGC1A Antibodies)) in up-regulating Insig-1/2 expression, defining a mechanistic pathway triggered by CD36 (show CD36 Antibodies), and leading to cholesterol depletion in hepatocytes.

  3. Our results indicated that the dysregulation of INSIG1 and SREBF1 (show SREBF1 Antibodies) caused by ART were observed not only in the fetus but also in the placenta, primarily in the ICSI group

  4. No significant associations were found between polymorphisms of INSIG1 gene and metabolic syndrome; however, INSIG1 and INSIG2 (show INSIG2 Antibodies) interactions were found in the significant 3-locus and 4-locus gene-gene interaction models.

  5. From genetic association studies, SNPs in INSIG1 (including the promoter region) influence hypertriglyceridemia.

  6. Common variation in INSIG1 is unlikely to have a major effect on risk of type 2 diabetes risk in white Europeans.

  7. These data suggest that p97 (show EIF4G2 Antibodies) recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes.

  8. INSIG1 and p41 (show EPB41 Antibodies) Arp2 (show ACTR2 Antibodies)/3 complex (p41-Arc (show ARPC1B Antibodies))reduced expression might be involved in gastric cancer development or progression

  9. INSIG-1 plays a role in regulating cholesterol concentration in human cells

  10. Data show that Insig-1 appears to play an essential role in the sterol-mediated trafficking of two proteins with sterol-sensing domains, HMG CoA reductase and SCAP.

Cow (Bovine) Insulin Induced Gene 1 (INSIG1) interaction partners

  1. In Nanyang Chinese cattle, seven common haplotypes were identified in the INSIG1 gene based on four coding region SNPs.

Mouse (Murine) Insulin Induced Gene 1 (INSIG1) interaction partners

  1. myeloid-cell-specific Insig1-/- mice are more susceptible to HSV-1 infection

  2. reducing Insig1 mRNA to a similar degree observed in morbidly obese human WAT accelerates adipocyte differentiation and enhances lipogenesis, and consequently, lipid accumulation

  3. we consistently observe involvement of gp78 (show AMFR Antibodies) in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 (show AMFR Antibodies) or TRC8 (show RNF139 Antibodies) in the robust sterol-accelerated degradation of HMG-CoA reductase (show HMGCR Antibodies).

  4. analysis of mRNA abundance and expression of SLC27A, ACC (show ACACA Antibodies), SCD (show SCD Antibodies), FADS, LPIN, INSIG, and PPARGC1 (show PPARGC1A Antibodies) gene isoforms in mouse mammary glands during the lactation cycle

  5. insig-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes

  6. the regulation of Insig-1 by PPARgamma (show PPARG Antibodies) agonists could in turn regulate SREBP processing and thus couple insulin (show INS Antibodies) sensitizers with the regulation of lipid homeostasis

  7. IRS2 (show IRS2 Antibodies), HK2 (show HK2 Antibodies) and INSIG1 are direct targets of TFE3 (show TFE3 Antibodies)

  8. Treatment of pregnant mice with the HMG-CoA reductase (show HMGCR Antibodies) inhibitor lovastatin reduced sterol synthesis in Insig1-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.

  9. Activation of CAR and PXR (show NR1I2 Antibodies) in mouse liver results in activation of Insig-1 along with reduced protein levels of the active form of sterol regulatory element binding protein 1 (Srebp-1 (show SREBF1 Antibodies)).

  10. Insig-1 is a direct PPARdelta (show PPARD Antibodies) target gene in hepatocytes. PPARdelta (show PPARD Antibodies) inhibited SREBP-1 (show SREBF1 Antibodies) activation via induction of Insig-1. Overexpression of PPARdelta (show PPARD Antibodies) induced the expression of Insig-1, suppressed SREBP-1 (show SREBF1 Antibodies) activation, and ameliorated hepatic steatosis.

Insulin Induced Gene 1 (INSIG1) Antigen Profile

Protein Summary

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with INSIG1

  • insulin induced gene 1 (INSIG1) antibody
  • insulin induced gene 1 (insig1) antibody
  • insulin induced gene 1 (Insig1) antibody
  • 1810013C12Rik antibody
  • CL-6 antibody
  • CL6 antibody
  • fb55a03 antibody
  • fi35b10 antibody
  • INSIG-1 antibody
  • wu:fb55a03 antibody
  • wu:fi35b10 antibody
  • zgc:55439 antibody

Protein level used designations for INSIG1

insulin induced gene 1 , INSIG-1 , insulin-induced gene 1 protein , INSIG-1 membrane protein , growth response protein (CL-6) , immediate-early protein CL-6 , insulin-induced growth response protein CL-6

GENE ID SPECIES
463839 Pan troglodytes
722766 Macaca mulatta
780766 Xenopus (Silurana) tropicalis
3638 Homo sapiens
334189 Danio rerio
446436 Xenopus laevis
420442 Gallus gallus
475554 Canis lupus familiaris
403162 Sus scrofa
511899 Bos taurus
231070 Mus musculus
64194 Rattus norvegicus
100689080 Cricetulus griseus
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