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Insulin Induced Gene 1 (INSIG1) ELISA Kits

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. Additionally we are shipping INSIG1 Antibodies (54) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human INSIG1 INSIG1 3638 O15503
Anti-Mouse INSIG1 INSIG1 231070 Q8BGI3
Anti-Rat INSIG1 INSIG1 64194 Q08755
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More ELISA Kits for INSIG1 Interaction Partners

Human Insulin Induced Gene 1 (INSIG1) interaction partners

  1. identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.

  2. Data show the essential role of PPARgamma (show PPARG ELISA Kits) and PPARgamma (show PPARG ELISA Kits) coactivator 1alpha (PGC-1alpha (show PPARGC1A ELISA Kits)) in up-regulating Insig-1/2 expression, defining a mechanistic pathway triggered by CD36 (show CD36 ELISA Kits), and leading to cholesterol depletion in hepatocytes.

  3. Our results indicated that the dysregulation of INSIG1 and SREBF1 (show SREBF1 ELISA Kits) caused by ART were observed not only in the fetus but also in the placenta, primarily in the ICSI group

  4. No significant associations were found between polymorphisms of INSIG1 gene and metabolic syndrome; however, INSIG1 and INSIG2 (show INSIG2 ELISA Kits) interactions were found in the significant 3-locus and 4-locus gene-gene interaction models.

  5. From genetic association studies, SNPs in INSIG1 (including the promoter region) influence hypertriglyceridemia.

  6. Common variation in INSIG1 is unlikely to have a major effect on risk of type 2 diabetes risk in white Europeans.

  7. These data suggest that p97 (show EIF4G2 ELISA Kits) recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes.

  8. INSIG1 and p41 (show EPB41 ELISA Kits) Arp2 (show ACTR2 ELISA Kits)/3 complex (p41-Arc (show ARPC1B ELISA Kits))reduced expression might be involved in gastric cancer development or progression

  9. INSIG-1 plays a role in regulating cholesterol concentration in human cells

  10. Data show that Insig-1 appears to play an essential role in the sterol-mediated trafficking of two proteins with sterol-sensing domains, HMG CoA reductase and SCAP.

Cow (Bovine) Insulin Induced Gene 1 (INSIG1) interaction partners

  1. In Nanyang Chinese cattle, seven common haplotypes were identified in the INSIG1 gene based on four coding region SNPs.

Mouse (Murine) Insulin Induced Gene 1 (INSIG1) interaction partners

  1. myeloid-cell-specific Insig1-/- mice are more susceptible to HSV-1 infection

  2. reducing Insig1 mRNA to a similar degree observed in morbidly obese human WAT accelerates adipocyte differentiation and enhances lipogenesis, and consequently, lipid accumulation

  3. we consistently observe involvement of gp78 (show AMFR ELISA Kits) in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 (show AMFR ELISA Kits) or TRC8 (show RNF139 ELISA Kits) in the robust sterol-accelerated degradation of HMG-CoA reductase (show HMGCR ELISA Kits).

  4. analysis of mRNA abundance and expression of SLC27A, ACC (show ACACA ELISA Kits), SCD (show SCD ELISA Kits), FADS, LPIN, INSIG, and PPARGC1 (show PPARGC1A ELISA Kits) gene isoforms in mouse mammary glands during the lactation cycle

  5. insig-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes

  6. the regulation of Insig-1 by PPARgamma (show PPARG ELISA Kits) agonists could in turn regulate SREBP processing and thus couple insulin (show INS ELISA Kits) sensitizers with the regulation of lipid homeostasis

  7. IRS2 (show IRS2 ELISA Kits), HK2 (show HK2 ELISA Kits) and INSIG1 are direct targets of TFE3 (show TFE3 ELISA Kits)

  8. Treatment of pregnant mice with the HMG-CoA reductase (show HMGCR ELISA Kits) inhibitor lovastatin reduced sterol synthesis in Insig1-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.

  9. Activation of CAR and PXR (show NR1I2 ELISA Kits) in mouse liver results in activation of Insig-1 along with reduced protein levels of the active form of sterol regulatory element binding protein 1 (Srebp-1 (show SREBF1 ELISA Kits)).

  10. Insig-1 is a direct PPARdelta (show PPARD ELISA Kits) target gene in hepatocytes. PPARdelta (show PPARD ELISA Kits) inhibited SREBP-1 (show SREBF1 ELISA Kits) activation via induction of Insig-1. Overexpression of PPARdelta (show PPARD ELISA Kits) induced the expression of Insig-1, suppressed SREBP-1 (show SREBF1 ELISA Kits) activation, and ameliorated hepatic steatosis.

INSIG1 Antigen Profile

Antigen Summary

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with INSIG1

  • insulin induced gene 1 (INSIG1) antibody
  • insulin induced gene 1 (insig1) antibody
  • insulin induced gene 1 (Insig1) antibody
  • 1810013C12Rik antibody
  • CL-6 antibody
  • CL6 antibody
  • fb55a03 antibody
  • fi35b10 antibody
  • INSIG-1 antibody
  • wu:fb55a03 antibody
  • wu:fi35b10 antibody
  • zgc:55439 antibody

Protein level used designations for INSIG1

insulin induced gene 1 , INSIG-1 , insulin-induced gene 1 protein , INSIG-1 membrane protein , growth response protein (CL-6) , immediate-early protein CL-6 , insulin-induced growth response protein CL-6

GENE ID SPECIES
463839 Pan troglodytes
722766 Macaca mulatta
780766 Xenopus (Silurana) tropicalis
3638 Homo sapiens
334189 Danio rerio
446436 Xenopus laevis
420442 Gallus gallus
475554 Canis lupus familiaris
403162 Sus scrofa
511899 Bos taurus
231070 Mus musculus
64194 Rattus norvegicus
100689080 Cricetulus griseus
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