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Insulin Receptor Substrate 4 Proteins (IRS4)

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Additionally we are shipping IRS4 Antibodies (38) and IRS4 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IRS4 8471 O14654
IRS4 16370 Q9Z0Y7
Rat IRS4 IRS4 315350  
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Top IRS4 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

IRS4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Insulin Receptor Substrate 4 (IRS4) Interaction Partners

Human Insulin Receptor Substrate 4 (IRS4) interaction partners

  1. The association of IRS4 with SSH1 (show SSH1 Proteins) contributes to localized activation of cofilin (show CFL1 Proteins) in membrane protrusions.

  2. Overexpression of IRS4 in U2OS cells activates PI3K (show PIK3CA Proteins) signalling.

  3. We genotyped single-nucleotide polymorphisms of IGF1 (show IGF1 Proteins), IGF2, IGF1R (show IGF1R Proteins), IGF2R (show IGF2R Proteins), IGFBP1 (show IGFBPI Proteins), IGFBP3 (show IGFBP3 Proteins), IGFBP5 (show IGFBP5 Proteins), IRS1 (show IRS1 Proteins), IRS2 (show IRS2 Proteins), and IRS (show IARS Proteins) in pancreatic cancer patients

  4. This study clearly demonstrates associations between body mass index and IRS-4 variants in schizophrenia patients, but not in healthy controls, pointing to a possible involvement of IRS-4 in the control of body weight in schizophrenia.

  5. Study for the first time identified IRS4 mutations in T-ALL.

  6. IRS-4 gene is not of importance for aetiology of the vast majority of schizophrenia cases, but a single patient with schizophrenia and a mutation in IRS-4 points to that the insulin (show INS Proteins) signalling system is of interest in the search for schizophrenia genes

  7. The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4.

  8. Insulin receptor substrate 4 associates with the protein IRAS (show NISCH Proteins)

  9. IRS-4 does not function as a substrate of the insulin (show INS Proteins) and the IGF-I receptor (show IGF1R Proteins) in primary muscle cells but may be involved in nonreceptor tyrosine kinase (show TXK Proteins) signaling.

  10. data demonstrate cell-specific alterations in IRS (show IARS Proteins) protein concentrations in theca cells from polycystic ovaries consistent with exaggerated amplification of the insulin (show INS Proteins) signal & which may play a role in ovarian hyperandrogenism & thecal hyperplasia

Mouse (Murine) Insulin Receptor Substrate 4 (IRS4) interaction partners

  1. conclude that Y103 is required for the internalization of hCTR1 (show SLC31A1 Proteins) in response to Cu, that this occurs by a mechanism other than phosphorylation and that mutation of Y103 modulates the interaction with IRS-4

  2. Down-regulation of the insulin receptor substrate 4 (Irs4) gene, may be an important event in the transition from age-related changes to Alzheimer's disease specific-changes.

  3. These data suggest that IRS (show IARS Proteins)-dependent signaling pathways work by recruiting different signaling molecules to determine specificity of IL-2R gamma (show IL2RG Proteins) superfamily cytokines.

  4. These data indicate that both insulin receptor (show INSR Proteins) substrate (IRS)-1 (show IRS1 Proteins) and -3, but not IRS-2 (show IRS2 Proteins) or IRS-4, play key roles in the differentiation of brown adipocytes.

  5. Data demonstrate that IRS4 interacts with the LR. This recruitment is leptin (show LEP Proteins) dependent and requires phosphorylation of the Y1077 motif of the LR.

  6. Protein kinase C-zeta (show PRKCZ Proteins) phosphorylates insulin receptor substrate-1 (show IRS1 Proteins), -3, and -4 but not -2 (show CNOT2 Proteins).

IRS4 Protein Profile

Protein Summary

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation..

Gene names and symbols associated with IRS4

  • insulin receptor substrate 4 (IRS4)
  • insulin receptor substrate 4 (irs4)
  • insulin receptor substrate 4 (Irs4)
  • IRS-4 protein
  • irs2 protein
  • irs2-a protein
  • IRS4 protein
  • PY160 protein

Protein level used designations for IRS4

insulin receptor substrate 4 , 160 kDa phosphotyrosine protein , phosphoprotein of 160 kDa , pp160 , IRS-2-A , insulin receptor substrate 2-A , insulin receptor substrate protein , insulin receptor substrate-undetermined designation , insulin receptor substrate-unique , xIRS-u

GENE ID SPECIES
492059 Canis lupus familiaris
514607 Bos taurus
100196925 Xenopus (Silurana) tropicalis
8471 Homo sapiens
16370 Mus musculus
315350 Rattus norvegicus
399388 Xenopus laevis
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