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IDE Proteins

(Insulin-Degrading Enzyme (IDE))
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
IDE Protein (AA 920-1019) (GST tag) IDE Protein (AA 920-1019) (GST tag) IDE Protein (AA 920-1019) (GST tag) (ABIN1307365)

IDE Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

IDE Protein (AA 1-1019) (GST tag) IDE Protein (AA 1-1019) (GST tag) IDE Protein (AA 1-1019) (GST tag) (ABIN1307363)

IDE Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

IDE Protein (AA 1-1019) (His tag) IDE Protein (AA 1-1019) (His tag) IDE Protein (AA 1-1019) (His tag) (ABIN3093008)

Crystallography grade IDE Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

IDE Proteins by Grade

Find IDE Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

IDE Proteins by Origin

Find IDE Proteins for a variety of species such as anti-Human IDE, anti-Mouse IDE, anti-Rat IDE. The species listed below are among those available. Click on a link to go to the corresponding products.

IDE Proteins by Source

Here you will find IDE Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

IDE Proteins by Protein Type

Here you can find IDE Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

IDE Proteins by Application

Find IDE Proteins validated for a specific application such as WB, SDS, ELISA, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular IDE Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307365
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307363
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093008
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137257
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2723516
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505065
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Human Cells
Validations
Cat. No. ABIN4370843
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Human Cells
Validations
Cat. No. ABIN7318623
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7395194
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7395197
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2750322
Quantity 5 applications
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN2723517
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6123665
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source
Validations
Cat. No. ABIN622898
Quantity 1 mg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN6380313
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our IDE Proteins

Kim, Lone, Saghatelian: "Analysis of the proteolysis of bioactive peptides using a peptidomics approach." in: Nature protocols, Vol. 8, Issue 9, pp. 1730-42, (2013) (PubMed).

Aliases for IDE Proteins

insulin degrading enzyme (IDE) Proteins
insulin-degrading enzyme (ide) Proteins
insulin-degrading enzyme (LOC591315) Proteins
insulin-degrading enzyme (CC1G_01115) Proteins
insulin-degrading enzyme (Bm1_26615) Proteins
insulin-degrading enzyme (PTRG_10875) Proteins
metallopeptidase (SJAG_01430) Proteins
insulin-degrading enzyme (EBI_21700) Proteins
insulin-degrading enzyme (VDBG_06702) Proteins
insulin-degrading enzyme (LOAG_08082) Proteins
insulin-degrading enzyme (PGTG_04982) Proteins
insulin-degrading enzyme (Tsp_00424) Proteins
insulin degrading enzyme (Ide) Proteins
1300012G03Rik Proteins
4833415K22Rik Proteins
AA675336 Proteins
AI507533 Proteins
IDE Proteins
INSDEGM Proteins
INSULYSIN Proteins
zgc:162603 Proteins
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