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Insulin-Degrading Enzyme Proteins (IDE)

IDE encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. Additionally we are shipping Insulin-Degrading Enzyme Antibodies (112) and Insulin-Degrading Enzyme Kits (44) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDE 15925  
Rat IDE IDE 25700 P35559
IDE 3416 P14735
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Top Insulin-Degrading Enzyme Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$855.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Cells Human His tag   10 μg Log in to see 5 Days
$203.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,030.69
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details
Human Un-conjugated   1 mg Log in to see 6 to 8 Days
$3,265.90
Details

IDE Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,

More Proteins for Insulin-Degrading Enzyme (IDE) Interaction Partners

Mouse (Murine) Insulin-Degrading Enzyme (IDE) interaction partners

  1. Findings show a key role of Pla2g3 (show PLA2G3 Proteins) on the reduction of IDE, and suggest that cerebrum specific increase of Pla2g3 (show PLA2G3 Proteins) is involved in the initiation and/or progression of Alzheimer disease.

  2. Abeta (show APP Proteins) level reduction by CALHM1 (show CALHM1 Proteins) could be explained by an increase in extracellular Abeta (show APP Proteins) degradation by insulin-degrading enzyme.

  3. Data suggest that protein restriction down-regulates expression of insulysin (insulin degrading enzyme) in liver and subsequently reduced insulin (show INS Proteins) clearance.

  4. IDE deficiency in bone marrow-derived cells results in larger atherosclerotic lesions, increased lesion-associated Abeta (show APP Proteins) and RAGE (show AGER Proteins), and higher serum cholesterol in male, Ldlr (show LDLR Proteins)(-/-) mice.

  5. The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta-cells.

  6. this study identified an upstream promoter element which blocks the reverse transcription of mouse IDE.

  7. Data show that in the absence of insulin-degrading enzyme (IDE), full-length calcitonin gene-related peptide (CGRP (show CALCA Proteins)) levels are elevated in vivo.

  8. role played by somatostatin (show SST Proteins) in preventing Abeta (show APP Proteins) accumulation by partially restoring IDE activity

  9. These data suggest that NOS2 (show NOS2 Proteins) upregulation impairs amyloid beta degradation through negative regulation of insulin degrading enzyme

  10. BRI2 (show ITM2B Proteins) protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).

Human Insulin-Degrading Enzyme (IDE) interaction partners

  1. the mechanistic and molecular features of IDE-26S proteasome (show Psmd4 Proteins) interaction in a cell experimental model, is reported.

  2. No significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with Alzheimer disease.

  3. results demonstrate that the polymorphisms rs1887922 and rs1999764 of the IDE gene are associated with late-onset Alzheimer disease susceptibility in the Xinjiang Han population

  4. Cognitive impairment is more frequent among those exposed to the C allele of the rs2209972 SNP of the insulin degrading enzyme gene.

  5. IDE does not play a major role in MHC class I antigen processing, confirming the dominant and almost exclusive role of the proteasome in cytosolic production of MHC class I ligands.

  6. using combinational in silico investigations, study identified that pathogenic nonsynonymous mutations corresponding to p.I54F, p.P122T, p.T533R, p.P581A and p.Y609A have more potential role in structural and functional deviations of IDE activity

  7. Our study provided evidence to IDE, PON1 (show PON1 Proteins), WFS1 (show WFS1 Proteins), POU2F1 (show POU2F1 Proteins), IL1alpha (show IL1A Proteins) and IL1beta (show IL1B Proteins) associated with T2D in Pakistanis.

  8. An upstream promoter element which blocks the antisense transcription of the human IDE promoter, was identified.

  9. Both IDE and type 2 diabetes are associated with executive function levels in older adults

  10. Conformational changes in IDE, including a swinging-door mechanism that permits the entry of short peptides into the catalytic chamber, governs the selective destruction of amyloidogenic peptides.

Insulin-Degrading Enzyme (IDE) Protein Profile

Protein Summary

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Gene names and symbols associated with Insulin-Degrading Enzyme Proteins (IDE)

  • insulin-degrading enzyme (IDE)
  • insulin-degrading enzyme (ide)
  • insulin-degrading enzyme (CC1G_01115)
  • insulin-degrading enzyme (Bm1_26615)
  • insulin-degrading enzyme (PTRG_10875)
  • insulin-degrading enzyme (SJAG_01430)
  • insulin-degrading enzyme (EBI_21700)
  • insulin-degrading enzyme (VDBG_06702)
  • insulin-degrading enzyme (LOAG_08082)
  • insulin-degrading enzyme (PGTG_04982)
  • insulin-degrading enzyme (Tsp_00424)
  • insulin degrading enzyme (Ide)
  • insulin-degrading enzyme (LOC100341888)
  • insulin-degrading enzyme (Ide)
  • 1300012G03Rik protein
  • 4833415K22Rik protein
  • AA675336 protein
  • AI507533 protein
  • IDE protein
  • INSDEGM protein
  • INSULYSIN protein
  • zgc:162603 protein

Protein level used designations for Insulin-Degrading Enzyme Proteins (IDE)

insulysin , insulin-degrading enzyme , insulin-degrading enzyme-like , insulin protease , insulinase , Abeta-degrading protease

GENE ID SPECIES
450608 Pan troglodytes
561390 Danio rerio
591315 Strongylocentrotus purpuratus
698640 Macaca mulatta
6009544 Coprinopsis cinerea okayama7130
6100223 Brugia malayi
6349187 Pyrenophora tritici-repentis Pt-1C-BFP
7051385 Schizosaccharomyces japonicus yFS275
8641122 Enterocytozoon bieneusi H348
9537184 Verticillium alfalfae VaMs.102
100071303 Equus caballus
100385143 Callithrix jacchus
100434053 Pongo abelii
100482236 Ailuropoda melanoleuca
9945508 Loa loa
10530847 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10901673 Trichinella spiralis
15925 Mus musculus
25700 Rattus norvegicus
3416 Homo sapiens
477768 Canis lupus familiaris
100341888 Oryctolagus cuniculus
100719651 Cavia porcellus
423814 Gallus gallus
100155309 Sus scrofa
523752 Bos taurus
101104194 Ovis aries
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