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IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. Additionally we are shipping IGFBP3 Antibodies (194) and IGFBP3 Kits (111) and many more products for this protein.
Showing 10 out of 41 products:
Human IGFBP3 Protein expressed in HEK-293 - ABIN2666742
Berrigan, Potischman, Dodd, Hursting, Lavigne, Barrett, Ballard-Barbash: Race/ethnic variation in serum levels of IGF-I and IGFBP-3 in US adults. in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2009
Show all 7 references for ABIN2666742
Human IGFBP3 Protein expressed in Human Cells - ABIN2002834
Cubbage, Suwanichkul, Powell: Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. in The Journal of biological chemistry 1990
Show all 4 references for ABIN2002834
Cynomolgus IGFBP3 Protein expressed in Human Cells - ABIN2009812
Ikonen, Liu, Hashimoto, Ma, Lee, Niikura, Nishimoto, Cohen: Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2003
Show all 3 references for ABIN2009812
insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 (show BMP4 Proteins) in zebrafish embryos
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
Study showed that IGFBP3 is dramatically induced in pancreatic tumors, and is abundantly produced in pancreatic cancer cells, causing muscle wasting through both impaired myogenesis via, at least, inhibition of IGF/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling.
The ratios of IGF-I (show IGF1 Proteins)/IGFBP-3 were increased in postmenopausal Taiwanese women with breast cancer, irrespective of their ages, ER and PR statuses, and HER2 (show ERBB2 Proteins) expression.
Higher IGF-I (show IGF1 Proteins) levels among postmenopausal women and an elevated IGF-I:IGFBP-3 ratio among all women were associated with higher TDLU counts ; these associations were strongest among women with elevated mammographic density
Insulin (show INS Proteins)-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells via integrin beta1 signaling.
endogenous IGFBP-3 is a p53 (show TP53 Proteins) target that plays a role in breast cancer cell responsiveness to DNA damaging therapy
Metformin resulted in a significant reduction of IGF-1 (show IGF1 Proteins), IGF-1 (show IGF1 Proteins): IGFBP-3 molar ratio, insulin (show INS Proteins), FBG and HOMA-IR. On the other hand, metformin caused a significant increase of IGFBP-3.
Data indicate that IGF-binding protein 3 (IGFBP3) and F3 gene expression levels in formalin fixed paraffin embedded (FFPE) prostate cancer tissue would provide an improved survival prediction for prostate cancer patients.
calcineurin (show PPP3CA Proteins) in astrocytes was activated by Amyloid beta, leading to IGFBP-3 release.
Circulating levels of IGF-1 (show IGF1 Proteins), IGFBP-3 and their molar ratio were not associated with the risk of occurrence of colorectal adenoma
Independent of obesity, high insulin (show INS Proteins) levels but reduced levels of IGFBP-3 were associated with increased lung cancer risk in current smokers.
IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury.
An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage.
Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis.
Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC (show FUT1 Proteins) migration.
Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development.
IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy.
IGFBP-3 activates inhibitory Smad (show SMAD1 Proteins) signaling in 3T3-L1 cells and that endogenous IGFBP-3 modulates their adipogenic differentiation by regulating cell sensitivity towards the inhibitory effect of TGFbeta (show TGFB1 Proteins).
Wnt (show WNT2 Proteins) signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3.
IGFBP-3 positively and negatively impacts on IGF1 (show IGF1 Proteins)-induced lung cancer development.
Bone morphogenetic protein-1 (show BMP1 Proteins) processes insulin-like growth factor-binding protein 3.
These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 (show NR4A1 Proteins) to the cytoplasm where it exerts its apoptotic effect.
The present study suggests that the insulin (show INS Proteins) like growth factor (IGF) system or imbalances between IGF and IGF binding (show HTRA1 Proteins) proteins may be involved in cystic ovary disease of cattle.
spatial and temporal patterns of expression of IGFBP-2 and -3 were markedly altered in the placentomes of nuclear transfer pregnancies
stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK (show MAPK1 Proteins) pathways in bovine mammary epithelial cells
Preincubation of erythroid cells with thrombospondin 1 (show THBS1 Proteins) eliminated the inhibitory activity of IGFBP-3
GH, IGF-I (show IGF1 Proteins) and IGF-IBP3 regulated the growth and development traits in different growth period.
delivery of insulin-like growth factor-1 (IGF-1 (show IGF1 Proteins), delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1 (show IGF1 Proteins), its receptor (IGF-1R (show IGF1R Proteins)), and a well known IGF-1 (show IGF1 Proteins) binding protein (IGFBP-3) by articular chondrocytes
Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 (show IGF1 Proteins) or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
IGF-I (show IGF1 Proteins), IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis
Even though LRP-1 (show LRP1 Proteins) mRNA and protein levels were dramatically reduced in LRP-1 (show LRP1 Proteins)-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1 (show LRP1 Proteins)-silenced and mock-silenced cultures.
cloning and sequencing; regulation of IGFBP-3 transcription by FSH (show BRD2 Proteins) suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I (show IGF1 Proteins)
Follicle-stimulating hormone stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK (show MAPK1 Proteins) pathways.
TAF4b may thus be the TFIID (show TBP Proteins) component that binds to the TBP (show TBP Proteins) site on the IGFBP-3 promoter and is essential for FSH (show BRD2 Proteins) induction of IGFBP-3.
The results suggest that the expression of IGF2 and IGFBP3 mRNA in the adipose tissue of pigs exhibits specific developmental changes and different patterns between the two pig breeds.
allelic frequency of TAT (show C6orf134 Proteins) in Chinese breeds was over 50%; allelic frequency of GGC (show GGCT Proteins) was over 50% in all European breeds. TAT/TAT (show C6orf134 Proteins) pigs scored higher in meat color than GGC/GGC (show GGCT Proteins) pigs. results implied that IGFBP-3 may affect meat quality & carcass traits.
Data suggest that metabolism of IGFBP3, IGF1 (insulin-like growth factor I), and IGF2 (insulin-like growth factor II) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
insulin-like growth factor-binding protein 3
, insulin-like growth factor binding protein 3
, IGF-binding protein 3
, acid stable subunit of the 140 K IGF complex
, binding protein 29
, binding protein 53
, growth hormone-dependent binding protein
, insulin-like growth factor binding protein-3
, insulin-like growth factor-binding protein (IGF-BP3)