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Insulin-Like Growth Factor I Proteins (IGF1)

The protein encoded by IGF1 is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. Additionally we are shipping and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse IGF1 IGF1 16000 P05017
Rat IGF1 IGF1 24482 P08025
IGF1 3479 P05019
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Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 1 to 2 Days

IGF1 Proteins by Origin and Source

Origin Expressed in

More Proteins for Insulin-Like Growth Factor I (IGF1) Interaction Partners

Mouse (Murine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. IGF1-deficient mice develop glomerular hypertrophy and increased kidney tubule growth.

  2. suppression of IGF-I signals in adult neural stem cells, induced a gain-of-function phenotype during aging, marked by optimized management of cell renewal, and enhanced olfactory sensory function

  3. stimulation of aerobic glycolysis via Igf signaling contributes to bone anabolism in response to PTH (show PTH Proteins).

  4. Findings indicate that insulin-like growth factor 1 (IGF-1) signaling inhibitors can promote proteostasis in mammalian cells, suggesting the potential to postpone the onset and slow the progression of neurodegenerative illnesses.

  5. Data show that brain and muscle ARNT (show ARNT Proteins) [aryl hydrocarbon receptor nuclear translocator (show ARNT Proteins)]-like protein 1 (BMAL1 (show ARNTL Proteins)) deficiency impaired calorie restriction (CR)-mediated changes in the plasma levels of insulin-like growth factor I (IGF-1).

  6. Data (including data from studies in knockout mice) suggest Socs2 (suppressor of cytokine signaling 2 (show SOCS2 Proteins)) regulates liver regeneration rate after partial hepatectomy, Ghr (growth hormone receptor (show GHR Proteins)) level via ubiquitination/proteolysis, and serum Igf1.

  7. Type IV collagenases, MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins), play important roles in hair cycle, and this could be mediated by induced expression of VEGF (show VEGFA Proteins), IGF-1, and TGF-beta (show TGFB1 Proteins).

  8. The present study demonstrates that decreased circulating IGF-1 levels are involved in human and murine chronic liver disease

  9. Study implicates a novel HDAC (show HDAC3 Proteins)/IGF-1 epigenetic pathway in the regulation of hypoxia-induced pulmonary hypertension.

  10. partial IGF-1 deficiency is responsible for the reduction in the expression of genes involved in glucose and lipid metabolism, resulting in dyslipidemia and hyperglycemia

Guinea Pig Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.

Human Insulin-Like Growth Factor I (IGF1) interaction partners

  1. our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD (show BEST1 Proteins)) levels and osteoporosis risk

  2. Anoikis resistance of oestrogen-responsive breast cancer cells depends upon IGF activation of the type I IGF receptor and PI3-kinase (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway.

  3. IGF-1 axis parameters are associated with increased old age survival and better functional status in nonagenarians

  4. Type 1 diabetic women delivering large for gestational age infants had placental GH levels similar to women without LGA (show GLS2 Proteins) infants.

  5. Patients with idiopathic normal pressure hydrocephalus had higher serum IGF-1 than controls.

  6. Herein, we provide a concise update and overview of the function and regulation of IGF-I and its role in leiomyoma growth.

  7. anticancer effect of Evo in human colon cancer may be partly mediated by downregulating HIF-1alpha (show HIF1A Proteins) expression, which is initiated by inactivating PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling transduction though decreasing the expression of IGF-1 in colon cancer cells.

  8. There was a positive correlation between the IGF1 levels of and those of inflammatory mediators in HIV Infections.

  9. PAPP-A (show PAPPA Proteins) in ascites and tissue-associated PAPP-A (show PAPPA Proteins) serve to increase IGF bioactivity and, thereby, to stimulate IGF-IR-mediated ovarian tumor growth.

  10. miR (show MLXIP Proteins)-130b-3p was downregulated in IPF lungs. miR (show MLXIP Proteins)-130b-3p downregulation contributed to the activation of fibroblasts and the dysregulated epithelial-mesenchymal crosstalk by promoting IGF-1 secretion from lung epithelium.

Cow (Bovine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.

  2. The association of IGF1, GH, and PIT1 (show POU1F1 Proteins) markers with growth and reproductive traits were assessed.

  3. These findings strongly support the concept that IGF-1 upregulates LHR (show LHCGR Proteins) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.

  4. Insulin (show INS Proteins)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (show MAPK1 Proteins)-mediated signaling pathways.

  5. Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.

  6. Uterine concentrations of IGFBPs are cycle stage specific and also suggests IGF1-dependent and -independent functions for IGFBPs during a time of major change in the developing embryo.

  7. This study evaluated the relationship of IGF-I levels to several other determinants of feed intake in Red Angus cross cattle.

  8. Production and reproduction traits in Holstein cattle associated with single nucleotide polymorphisms in the IGF1 gene.

  9. There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y (show NPY Proteins), leptin (show LEP Proteins), and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.

  10. Direct additive genetic correlations suggest that selection for greater IGF-I concentration could lead to increased conception rate and calving rate, and decreased age at first calving in heifers.

Pig (Porcine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Results show that expression changes of IGF1 genes were associated with C/EBP (show CEBPA Proteins) b expression during embryonic and postnatal development in porcine liver.

  2. genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.

  3. IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.

  4. IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.

  5. alpha-linolenic acid increased IGF-I secretion from hepatocytes.

  6. Copper can stimulate chondrocyte proliferation by promoting the expression of IGF-1.

  7. The results show that modulation of plasma insulin (show INS Proteins) levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I levels are less easily modified.

  8. The results suggested that IFG (show IFNG Proteins)-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.

  9. Plasma ghrelin (show GHRL Proteins) level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasma IGF-1 level and myocardial ghrelin (show GHRL Proteins) mRNA expression were down-regulated in the chronic cyanotic immature piglets.

  10. IGFI signaling pathway regulates myofibre hypertrophy postnatally via complicated signal effectors, which may have negative impact on meat quality simultaneously.

Rabbit Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.

  2. Our studies demonstrate that the active SVCT2 (show SLC23A2 Proteins) is expressed in IVD (show IVD Proteins) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.

  3. increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (show INS Proteins) and IGF.

  4. IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors

  5. Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.

Horse (Equine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (show IGFBP3 Proteins)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).

  2. The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor (show IGF1R Proteins) and the effect of dietary carbohydrates on their expression are reported.

  3. Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.

  4. Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (show IGF1R Proteins) is present in spermatogonia, spermatocytes and Leydig cells.

  5. Hsp90 (show HSP90AB1 Proteins) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.

Rainbow Trout (Oncorhynchus mykiss) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Findings show similar regulatory growth hormone (GH (show GH1 Proteins)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.

  2. the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (show INS Proteins)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (show TNF Proteins).

  3. Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.

IGF1 Protein Profile

Protein Summary

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with IGF1

  • insulin-like growth factor 1 (Igf1)
  • insulin-like growth factor 1 (somatomedin C) (IGF1)
  • insulin-like growth factor I (LOC100136741)
  • prepro IGF-I (IGF-I)
  • C730016P09Rik protein
  • IGF-1 protein
  • IGF-I protein
  • IGF-IB protein
  • IGF1 protein
  • IGF1A protein
  • IGFI protein
  • IGFIA protein
  • Npt2B protein

Protein level used designations for IGF1

insulin-like growth factor I , somatomedin , IGF-I , IGF-IA , IGF-IB , MGF , insulin-like growth factor 1 , insulin-like growth factor IA , insulin-like growth factor IB , mechano growth factor , somatomedin-C , insulin-like growth factor-1 , class 1 insulin-like growth factor I preproprotein , insulin growth factor-1 , insulin like growth factor 1 , insulin-like growth factor I (somatomedin C) , insulin-like growth factor I variant 1 , prepro-IGF-I , somatomedin C , Insulin-like growth factor I , Somatomedin , insulin like growth factor-1 , insulin-like growth factor-I

16000 Mus musculus
100135551 Cavia porcellus
24482 Rattus norvegicus
3479 Homo sapiens
418090 Gallus gallus
281239 Bos taurus
397491 Sus scrofa
443318 Ovis aries
100008668 Oryctolagus cuniculus
610255 Canis lupus familiaris
100034198 Equus caballus
100136741 Oncorhynchus mykiss
100860838 Capra hircus
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