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Insulin-Like Growth Factor I Proteins (IGF1)

The protein encoded by IGF1 is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. Additionally we are shipping and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse IGF1 IGF1 16000 P05017
Rat IGF1 IGF1 24482 P08025
IGF1 3479 P05019
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Top IGF1 Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 1 to 2 Days
$100.22
Details

IGF1 Proteins by Origin and Source

Origin Expressed in
Human

More Proteins for Insulin-Like Growth Factor I (IGF1) Interaction Partners

Mouse (Murine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Serum IGF-1 level of HFD TRAMP (show DPT Proteins) mice was significantly higher than that of normal diet TRAMP (show DPT Proteins) mice, increasing with age. The IGF-1 related pathway played an important role in high-fat diet promotion of TRAMP (show DPT Proteins) mouse PCa (show ENPP1 Proteins) development and progression.

  2. Upregulation of miR26b in mouse cells downregulated the insulinlike growth factor 1 (IGF1) protein expression level and promoted beta-amyloid production.

  3. These results indicate that there is a tissue-specific regulation of IGF-1/PI3K/Akt (show AKT1 Proteins) during normal aging and upon dietary restriction to help maintain the metabolic status of these tissues at those phases of animal's lifespan.

  4. IGF-1 deficiency is responsible for increased brain oxidative damage, edema, and impaired learning and memory capabilities which are rescued by IGF-1 replacement therapy.

  5. these data suggest the age-related loss of vertebral bone density in females can be reduced by modifying circulating IGF-1 levels early in life.

  6. IGF-1 promotes the growth and metastasis of hepatocellular carcinoma by inhibition of proteasome-mediated cathepsin B (show CTSB Proteins) degradation.

  7. After ischemia-reperfusion, the expression of miR (show MLXIP Proteins)-29a and Let7f increased, while the expression of IGF-1 decreased significantly in the animal model assay.

  8. analysis of the vestibular organ of the Igf1 deficient mouse

  9. IGF1-deficient mice develop glomerular hypertrophy and increased kidney tubule growth.

  10. suppression of IGF-I signals in adult neural stem cells, induced a gain-of-function phenotype during aging, marked by optimized management of cell renewal, and enhanced olfactory sensory function

Guinea Pig Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.

Human Insulin-Like Growth Factor I (IGF1) interaction partners

  1. High IGF-1 expression is Associated with Acne Vulgaris.

  2. The data suggest that IGF-I is modulated distinctly in different clinical forms of tegumentary leishmaniasis, and that it seemingly exerts effect on parasite growth.

  3. IGF-1 levels were increased in obsessive-compulsive disorder patients compared to controls.

  4. CrkII (show CRK Proteins) mediates IGF-1 signaling and further balances pancreatic ductal adenocarcinoma biological behaviors via Erk1/2 and Akt (show AKT1 Proteins) pathway

  5. The results, specifically that lower serum IGF-I was associated with cognitive impairment, suggest that metabolism of IGF-I may be involved in the pathogenesis of cognitive deficits in Alzheimer's disease.

  6. IGF-1 signaling activated survivin (show BIRC5 Proteins) expression and controlled the expression of EMT (show ITK Proteins) biomarkers in the development of GC.

  7. methylation of IGF-1, IGF1R (show IGF1R Proteins), IGFBP3 (show IGFBP3 Proteins), and IGF-1 + IGF1R (show IGF1R Proteins) + IGFBP3 (show IGFBP3 Proteins) was closely linked with the occurrence of EC and patients' clinicopathological features. Besides, the methylation status of the target genes and the expressions of IGF-1 and IGF-1R (show IGF1R Proteins) protein were independent factors of EC prognosis, which could provide a direction for the prognosis and treatment of EC.

  8. MEF2D (show MEF2D Proteins) regulates IGF-1-induced proliferation and apoptosis in CM development, indicating IGF-1-MEF2D (show MEF2D Proteins) pathway may be a useful target for treatment.

  9. The results showed that both the gene polymorphisms of IGFBP3 (show IGFBP3 Proteins) and the abnormal protein expression of serum IGFBP3 (show IGFBP3 Proteins) and IGF1 were closely associated with the development of osteonecrosis of the femoral head.

  10. Host EphA4 (show EPHA4 Proteins) expression regulates cancer development mainly via EphA4 (show EPHA4 Proteins)-mediated IGF1 synthesis signal.

Cow (Bovine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.

  2. The association of IGF1, GH, and PIT1 (show POU1F1 Proteins) markers with growth and reproductive traits were assessed.

  3. These findings strongly support the concept that IGF-1 upregulates LHR (show LHCGR Proteins) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.

  4. Insulin (show INS Proteins)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (show MAPK1 Proteins)-mediated signaling pathways.

  5. Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.

  6. Uterine concentrations of IGFBPs are cycle stage specific and also suggests IGF1-dependent and -independent functions for IGFBPs during a time of major change in the developing embryo.

  7. This study evaluated the relationship of IGF-I levels to several other determinants of feed intake in Red Angus cross cattle.

  8. Production and reproduction traits in Holstein cattle associated with single nucleotide polymorphisms in the IGF1 gene.

  9. There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y (show NPY Proteins), leptin (show LEP Proteins), and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.

  10. Direct additive genetic correlations suggest that selection for greater IGF-I concentration could lead to increased conception rate and calving rate, and decreased age at first calving in heifers.

Pig (Porcine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (show HGF Proteins) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.

  2. Results show that expression changes of IGF1 genes were associated with C/EBP (show CEBPA Proteins) b expression during embryonic and postnatal development in porcine liver.

  3. genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.

  4. IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.

  5. IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.

  6. alpha-linolenic acid increased IGF-I secretion from hepatocytes.

  7. Copper can stimulate chondrocyte proliferation by promoting the expression of IGF-1.

  8. The results show that modulation of plasma insulin (show INS Proteins) levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I levels are less easily modified.

  9. The results suggested that IFG (show IFNG Proteins)-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.

  10. Plasma ghrelin (show GHRL Proteins) level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasma IGF-1 level and myocardial ghrelin (show GHRL Proteins) mRNA expression were down-regulated in the chronic cyanotic immature piglets.

Rabbit Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.

  2. Our studies demonstrate that the active SVCT2 (show SLC23A2 Proteins) is expressed in IVD (show IVD Proteins) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.

  3. increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (show INS Proteins) and IGF.

  4. IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors

  5. Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.

Horse (Equine) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (show IGFBP3 Proteins)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).

  2. The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor (show IGF1R Proteins) and the effect of dietary carbohydrates on their expression are reported.

  3. Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.

  4. Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (show IGF1R Proteins) is present in spermatogonia, spermatocytes and Leydig cells.

  5. Hsp90 (show HSP90AB1 Proteins) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.

Rainbow Trout (Oncorhynchus mykiss) Insulin-Like Growth Factor I (IGF1) interaction partners

  1. Findings show similar regulatory growth hormone (GH (show GH1 Proteins)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.

  2. the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (show INS Proteins)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (show TNF Proteins).

  3. Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.

Goat Insulin-Like Growth Factor I (IGF1) interaction partners

  1. These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.

IGF1 Protein Profile

Protein Summary

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with IGF1

  • insulin-like growth factor 1 (Igf1)
  • insulin-like growth factor 1 (somatomedin C) (IGF1)
  • insulin-like growth factor I (LOC100136741)
  • prepro IGF-I (IGF-I)
  • C730016P09Rik protein
  • IGF-1 protein
  • IGF-I protein
  • IGF-IB protein
  • IGF1 protein
  • IGF1A protein
  • IGFI protein
  • IGFIA protein
  • Npt2B protein

Protein level used designations for IGF1

insulin-like growth factor I , somatomedin , IGF-I , IGF-IA , IGF-IB , MGF , insulin-like growth factor 1 , insulin-like growth factor IA , insulin-like growth factor IB , mechano growth factor , somatomedin-C , insulin-like growth factor-1 , class 1 insulin-like growth factor I preproprotein , insulin growth factor-1 , insulin like growth factor 1 , insulin-like growth factor I (somatomedin C) , insulin-like growth factor I variant 1 , prepro-IGF-I , somatomedin C , Insulin-like growth factor I , Somatomedin , insulin like growth factor-1 , insulin-like growth factor-I

GENE ID SPECIES
16000 Mus musculus
100135551 Cavia porcellus
24482 Rattus norvegicus
3479 Homo sapiens
418090 Gallus gallus
281239 Bos taurus
397491 Sus scrofa
443318 Ovis aries
100008668 Oryctolagus cuniculus
610255 Canis lupus familiaris
100034198 Equus caballus
100136741 Oncorhynchus mykiss
100860838 Capra hircus
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