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IGF2BP2 encodes a member of the IGF-II mRNA-binding protein (IMP) family. Additionally we are shipping IGF2BP2 Antibodies (133) and IGF2BP2 Kits (1) and many more products for this protein.
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Human IGF2BP2 Protein expressed in HEK-293 Cells - ABIN2181267
Zhang, Chan, Peng, Tan: A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma. in The Journal of experimental medicine 1999
Our data suggests that IGF2BP2 polymorphisms are associated with Type 2 Diabetes Mellitus in Asian populations.
Study conclude that integration of genomic and transcriptomic data implicate circulating IGF2BP2 mRNA levels associated with glucose and insulin (show INS Proteins) homeostasis
IGF2BP2 as a post-transcriptional regulatory mRNA-binding factor that contributes to Colorectal carcinogenesis.
p62/IMP2 stimulates cell migration and reduces cell adhesion, contributing to breast cancer progression.
IMP2 (show IMPA2 Proteins) expression is higher in ovarian and endometrial high-grade serous carcinomas (HGSC) than in ovarian or endometrial endometrioid carcinoma. Knockdown in ovarian HGSC cell line decreased cell proliferation.
Our results suggest IGF2BP2 and KCNQ1 (show KCNQ1 Proteins) polymorphisms might be independent predictors of chemotherapeutic response
HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion
Imp2 (show IMPA2 Proteins) regulates the activity of IGF2, which further activates PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling.
Data show that insulin-like growth factor-2 (show IGF2 Proteins)-mRNA-binding proteins IGF2BP1 (show IGF2BP1 Proteins), IGF2BP2, and IGF2BP3 (show IGF2BP3 Proteins) are direct targets of microRNA-1275 (miR (show MLXIP Proteins)-1275).
The IGF2BP2 gene rs1470579 and rs4402960 polymorphisms were associated with type 2 diabetes patients and therapeutic efficacy of pioglitazone in this Chinese population
results reveal a highly distinctive axonal enrichment of IMP2, show that it interacts with a network of axon guidance-related mRNAs, and reveal that it is required for normal axon pathfinding during vertebrate development.
these results highlight the previously undiscovered and crucial role of the HMGB2 (show HMGB2 Proteins)-IGF2BP2 axis in myogenesis and muscle regeneration.
p62/IMP2 promotes hepatocarcinogenesis by an amplification of inflammation.
IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 (show UCP1 Proteins) mRNA and Other mRNAs encoding mitochondrial proteins.
p62/IGF2BP2-2 drives the progression of NAFLD through elevation of hepatic iron deposition and increased production of hepatic free cholesterol.
Mice with a liver overexpression of insulin-like growth factor 2 (IGF2 (show IGF2 Proteins)) mRNA-binding protein p62/IMP2-2/IGF2BP2-2 show elevated Ccl2 (show CCL2 Proteins) levels, which models all stages of non-alcoholic fatty liver disease.
data demonstrate that the HMGA2-IGF2BP2 axis functions as a key regulator of satellite cell activation and therefore skeletal muscle development
oncofetal insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, IGF2BP2) regulates oxidative phosphorylation (OXPHOS) in primary glioblastoma (GBM) sphere cultures (gliomaspheres)
Dual phosphorylation of IMP2 at the mTOR sites is evident in the mouse embryo, likely coupling nutrient sufficiency to IGF2 expression and fetal growth
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
IGF-II mRNA-binding protein 2
, IGF2 mRNA-binding protein 2
, VICKZ family member 2
, hepatocellular carcinoma autoantigen p62
, insulin-like growth factor 2 mRNA-binding protein 2
, insulin-like growth factor 2, binding protein 2