anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) Antibodies

IGF2R encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. Additionally we are shipping IGF2R Kits (24) and IGF2R Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IGF2R 3482 P11717
IGF2R 16004 Q07113
IGF2R 25151  
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Top anti-IGF2R Antibodies at antibodies-online.com

Showing 10 out of 139 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using IGF2R (Ab-2484) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using IGF2R (Ab-2484) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated CyTOF, FACS, WB Flow Cytometry: IGF-II R/Mannose 6 Phosphate Receptor (Cation independent) Antibody (MEM-238) [ABIN269096] - Analysis using the FITC conjugate of ABIN269096. Staining of human peripheral blood monocytes following permeablisation with Leucoperm (Fix & Perm) (BUF09). Western Blot: IGF-II R/Mannose 6 Phosphate Receptor (Cation independent) Antibody (MEM-238) [ABIN269096] - Fig. 1. Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. Lane 1: immunostaining with anti-CD222 (MEM-238) Lane 2: immunostaining with Isotype mouse IgG1 control (PPV-06). 0.1 mg Log in to see 7 to 9 Days
$381.94
Details
Cow Mouse Un-conjugated CyTOF, ELISA, FACS, ICC, IF, IHC, IHC (p), IP, WB Immunocytochemistry/Immunofluorescence: Mannose 6 Phosphate Receptor (Cation independent) Antibody (2G11) [ABIN152673] - Mannose 6-Phosphate Receptor staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Mannose 6-Phosphate Receptor at a dilution of 1:20 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated. Immunohistochemistry: Mannose 6 Phosphate Receptor (Cation independent) Antibody (2G11) [ABIN152673] - Staining of human testis using ABIN152673 antibody at 1:100. 0.1 mL Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-IGF2R Polyclonal Antibody, Unconjugated (ABIN719711) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Goat Fluorescein FACS Detection of IGF-II R in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Goat Anti-Human IGF-II R Fluorescein-conjugated Antigen Affinity-purified Polyclonal Antibody. Detection of IGF-II R in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with Goat Anti-Human IGF-II R Fluorescein-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$267.75
Details
Human Mouse Un-conjugated FACS, WB   0.1 mg Log in to see 6 to 8 Days
$308.00
Details
Human Mouse Un-conjugated FACS, WB   0.1 mg Log in to see 6 to 8 Days
$286.00
Details
Human Mouse PE FACS, WB Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. Lane 1: immunostaining with anti-CD222 (MEM-238) Lane 2: immunostaining with Isotype mouse IgG1 control (PPV-06) 100 Tests Log in to see 5 to 7 Days
$334.95
Details
Human Mouse APC FACS   100 Tests Log in to see 6 to 8 Days
$357.50
Details

IGF2R Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-IGF2R Antibodies

  1. Cow (Bovine) Monoclonal IGF2R Primary Antibody for CyTOF, ELISA - ABIN152673 : Dintzis, Velculescu, Pfeffer: Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor. in The Journal of biological chemistry 1994 (PubMed)
    Show all 7 Pubmed References

  2. Human Monoclonal IGF2R Primary Antibody for FACS, WB - ABIN192250 : Leksa, Godár, Cebecauer, Hilgert, Breuss, Weidle, Horejsí, Binder, Stockinger: The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal IGF2R Primary Antibody for FACS, WB - ABIN94039 : Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: Rapid multiplex analysis of lipid raft components with single-cell resolution. in Science signaling 2015 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal IGF2R Primary Antibody for FACS, WB - ABIN609650 : Gasanov, Koina, Beagley, Aitken, Hansbro: Identification of the insulin-like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes. in Infection and immunity 2005 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal IGF2R Primary Antibody for IF (p), IHC (p) - ABIN719711 : Geng, Yang, Li, Song, Liu, Qiu, Liu, Yang: Insulin-like growth factor-2 enhances functions of antigen (Ag)-specific regulatory B cells. in The Journal of biological chemistry 2014 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal IGF2R Primary Antibody for CyTOF, FACS - ABIN269096 : El-Shewy, Lee, Obeid, Jaffa, Luttrell: The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal IGF2R Primary Antibody for FACS, IF - ABIN2479308 : Rezgui, Williams, Savage, Prince, Zaccheo, Jones, Crump, Hassan: Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth. in Journal of molecular endocrinology 2009 (PubMed)

  8. Human Polyclonal IGF2R Primary Antibody for FACS - ABIN4895819 : Mancini, Gariboldi, Taiana, Bonzi, Craparotta, Pagin, Monti: Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. in British journal of cancer 2014 (PubMed)

More Antibodies against IGF2R Interaction Partners

Human Insulin-Like Growth Factor 2 Receptor (IGF2R) interaction partners

  1. Findings indicate that IGF2R expression is controlled posttranscriptionally by two factors that associate with Igf2r mRNA and suggest that miR (show MLXIP Antibodies)-195 and CUGBP1 (show CELF1 Antibodies) dampen IGF signaling by inhibiting IGF2R translation.

  2. Previously characterized disease-causing mutations in IGF2, IGF1R (show IGF1R Antibodies), IGF2R, or IGFALS (show IGFALS Antibodies) all were found in the general population but with allele frequencies of <1:30,000.

  3. IGF2R plays a minor role in regulating the activity of IGF1R (show IGF1R Antibodies) under a variety of conditions and that due to their high expression levels, IGFBPs are the dominant mechanism to regulating IGF network activation

  4. Data show one single nucleotide polymorphism (SNP) in Fox transcription factor FOXO3 (FOXO3 (show FOXO3 Antibodies)) was significantly associated with longevity, and the six SNPs in proto-oncogene (show RAB1A Antibodies) protein AKT1 (AKT1 (show AKT1 Antibodies)) gene and in IGF-2 Receptor (IGF-2R) gene are not.

  5. CREB (show CREB1 Antibodies) plays an important role in the inhibition of IGF2R expression by binding to the IGF2R promoter and further suppresses H9c2 cardiomyoblast cell apoptosis induced by IGF2R signaling under hypoxic conditions.

  6. This study showed that Plasma IGF2R levels were positively correlated with plasma HIV viral load.

  7. IGF2R gene polymorphism and circulating IGF2R are associated with T2DM

  8. The macrophage-specific markers CD163 (show CD163 Antibodies), soluble CD163 (show CD163 Antibodies), and soluble MR are increased in septic patients.

  9. Results show that insulin-like growth factor II (IGF-II) overexpression enhanced the levels of amyloid precursor protein (APP (show APP Antibodies)) in SK-N-AS neuroblastoma (show ARHGEF16 Antibodies) cells.

  10. IGF2R silencing significantly enhanced the chemo-resistance of NSCLC cell lines to cisplatin treatment.

Mouse (Murine) Insulin-Like Growth Factor 2 Receptor (IGF2R) interaction partners

  1. Selective M6PR (show M6PR Antibodies) down-regulation has a critical role in CD8 (show CD8A Antibodies)(+) T cell survival.

  2. Expression of imprinted gene Igf2r was unregulated in haploid androgenetic/gynogenetic blastocysts.

  3. that an elevation in IGF-II receptor levels can influence the expression profiles of transcripts as well as proteins that are involved in AD pathogenesis.

  4. DNA methylation (show HELLS Antibodies) changes were noted in the Igf2r gene during chronic cystitis in a murine model.

  5. Airn expression is both necessary and sufficient to silence Igf2r throughout embryonic stem cell differentiation.

  6. The results excluded a role for spliced and unspliced Airn lncRNA products and for Airn nuclear size and location in silencing Igf2r. Instead, silencing only required Airn transcriptional overlap of the Igf2r promoter, which interferes with RNA polymerase II recruitment in the absence of repressive chromatin.

  7. mannose 6-phosphate/IGF2R knock-down in receptor-positive mouse hepatocytes causes increased cathepsin secretion as well as enhanced cell motility and invasiveness

  8. enhanced CI-MPR expression might improve the efficacy of enzyme replacement therapy in Pompe disease through enhancing receptor-mediated uptake of GAA (show GAA Antibodies).

  9. The interaction of sM6P/IGF2R with Plg (show PLG Antibodies) may be an important regulatory mechanism to inhibit migration of cells using the uPA (show PLAU Antibodies)/uPAR (show PLAUR Antibodies) system.

  10. Results demonstrate a novel role for IGF2R as an IFNgamma-inducible microglial protein involved in regulation of HIV and chemokine (show CCL1 Antibodies) expression.

Pig (Porcine) Insulin-Like Growth Factor 2 Receptor (IGF2R) interaction partners

  1. IGF2R is expressed from both parental alleles although differential allelic expression may occur.

Cow (Bovine) Insulin-Like Growth Factor 2 Receptor (IGF2R) interaction partners

  1. study hypothesizes that reduced granulosa cell insulin-like growth factor II receptor expression in F2 follicles of Twinner cows may play a role in the development of 2 or more dominant follicles

  2. imprinting of Bos taurus IGF2R is similar to mouse except in placenta, which could indicate an effect of reproductive strategy

  3. Increases in CYP19A1 (show CYP19A1 Antibodies) and FSHR (show FSHR Antibodies) mRNA expression and decreases in IGF2R mRNA expression in follicles of Twinners support the hypothesis that increased follicular development and steroidogenesis result from increased extra-ovarian IGF-1 (show IGF1 Antibodies) production.

  4. Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation (show HELLS Antibodies) patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.

  5. Study demonstrates associations between IGF2R polymorphisms and growth- and body-related traits in cattle.

  6. Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 Antibodies), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.

  7. Expression and binding properties of mannose-6-phosphate receptors CD-MPR (show M6PR Antibodies) and CI-MPR differ during perinatal development in rat liver.

  8. the interaction between uPAR (show PLAUR Antibodies) and Man-6-P/IGF2R is a low percentage binding event and that suPAR and full-length uPAR (show PLAUR Antibodies) bind the Man-6-P/IGF2R by different mechanisms.

  9. Results describe the crystal structure of the N-terminal 432 residues of the cation-independent mannose 6-phosphate receptor, which encompass three out of the 15 repetitive domains of its extracytoplasmic region.

  10. CI-MPR contains a third Man-6-P recognition site that is located in domain 5 and that exhibits lower affinity than the carbohydrate-binding sites present in domains 1-3 and 9

IGF2R Antigen Profile

Protein Summary

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.

Gene names and symbols associated with IGF2R

  • insulin-like growth factor 2 receptor (igf2r) antibody
  • insulin-like growth factor 2 receptor (IGF2R) antibody
  • insulin-like growth factor 2 receptor (Igf2r) antibody
  • AI661837 antibody
  • CD222 antibody
  • CI-MPR antibody
  • CIMPR antibody
  • M6P-R antibody
  • M6P/IGF2R antibody
  • MPR1 antibody
  • Mpr300 antibody
  • MPRI antibody

Protein level used designations for IGF2R

insulin-like growth factor 2 receptor , 300 kDa mannose 6-phosphate receptor , CI Man-6-P receptor , CI-MPR , IGF-II receptor , M6P/IGF2 receptor , M6P/IGF2R , M6PR , MPR 300 , cation-independent mannose-6 phosphate receptor , cation-independent mannose-6-phosphate receptor , insulin-like growth factor II receptor , IGF-II/CI-MPR , cation-independent MPR , cation-independent mannose 6-phosphate receptor , mannose-6-phosphate receptor, cation independent , cation-independent mannose 6 phosphate receptor , insulin-like growth factor receptor type 2

GENE ID SPECIES
496491 Xenopus (Silurana) tropicalis
100027969 Monodelphis domestica
3482 Homo sapiens
16004 Mus musculus
25151 Rattus norvegicus
395817 Gallus gallus
484067 Canis lupus familiaris
397214 Sus scrofa
281849 Bos taurus
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